Paneth cells in farm animals: current status and future direction
Abstract A healthy intestine plays an important role in the growth and development of farm animals. In small intestine, Paneth cells are well known for their regulation of intestinal microbiota and intestinal stem cells (ISCs). Although there has been a lot of studies and reviews on human and murine...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | Journal of Animal Science and Biotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40104-023-00905-5 |
| _version_ | 1797557400665849856 |
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| author | Chenbin Cui Lindeng Li Lin Wu Xinru Wang Yao Zheng Fangke Wang Hongkui Wei Jian Peng |
| author_facet | Chenbin Cui Lindeng Li Lin Wu Xinru Wang Yao Zheng Fangke Wang Hongkui Wei Jian Peng |
| author_sort | Chenbin Cui |
| collection | DOAJ |
| description | Abstract A healthy intestine plays an important role in the growth and development of farm animals. In small intestine, Paneth cells are well known for their regulation of intestinal microbiota and intestinal stem cells (ISCs). Although there has been a lot of studies and reviews on human and murine Paneth cells under intestinal homeostasis or disorders, little is known about Paneth cells in farm animals. Most farm animals possess Paneth cells in their small intestine, as identified by various staining methods, and Paneth cells of various livestock species exhibit noticeable differences in cell shape, granule number, and intestinal distribution. Paneth cells in farm animals and their antimicrobial peptides (AMPs) are susceptible to multiple factors such as dietary nutrients and intestinal infection. Thus, the comprehensive understanding of Paneth cells in different livestock species will contribute to the improvement of intestinal health. This review first summarizes the current status of Paneth cells in pig, cattle, sheep, horse, chicken and rabbit, and points out future directions for the investigation of Paneth cells in the reviewed animals. |
| first_indexed | 2024-03-10T17:17:28Z |
| format | Article |
| id | doaj.art-b366e6fcf4494cab80efd2ae1f92ea76 |
| institution | Directory Open Access Journal |
| issn | 2049-1891 |
| language | English |
| last_indexed | 2024-03-10T17:17:28Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Animal Science and Biotechnology |
| spelling | doaj.art-b366e6fcf4494cab80efd2ae1f92ea762023-11-20T10:28:35ZengBMCJournal of Animal Science and Biotechnology2049-18912023-08-0114111310.1186/s40104-023-00905-5Paneth cells in farm animals: current status and future directionChenbin Cui0Lindeng Li1Lin Wu2Xinru Wang3Yao Zheng4Fangke Wang5Hongkui Wei6Jian Peng7Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural UniversityDepartment of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural UniversityDepartment of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural UniversityDepartment of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural UniversityDepartment of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural UniversityDepartment of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural UniversityDepartment of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural UniversityDepartment of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural UniversityAbstract A healthy intestine plays an important role in the growth and development of farm animals. In small intestine, Paneth cells are well known for their regulation of intestinal microbiota and intestinal stem cells (ISCs). Although there has been a lot of studies and reviews on human and murine Paneth cells under intestinal homeostasis or disorders, little is known about Paneth cells in farm animals. Most farm animals possess Paneth cells in their small intestine, as identified by various staining methods, and Paneth cells of various livestock species exhibit noticeable differences in cell shape, granule number, and intestinal distribution. Paneth cells in farm animals and their antimicrobial peptides (AMPs) are susceptible to multiple factors such as dietary nutrients and intestinal infection. Thus, the comprehensive understanding of Paneth cells in different livestock species will contribute to the improvement of intestinal health. This review first summarizes the current status of Paneth cells in pig, cattle, sheep, horse, chicken and rabbit, and points out future directions for the investigation of Paneth cells in the reviewed animals.https://doi.org/10.1186/s40104-023-00905-5Antimicrobial peptideFarm animalIntestinal organoidIntestinePaneth cell |
| spellingShingle | Chenbin Cui Lindeng Li Lin Wu Xinru Wang Yao Zheng Fangke Wang Hongkui Wei Jian Peng Paneth cells in farm animals: current status and future direction Journal of Animal Science and Biotechnology Antimicrobial peptide Farm animal Intestinal organoid Intestine Paneth cell |
| title | Paneth cells in farm animals: current status and future direction |
| title_full | Paneth cells in farm animals: current status and future direction |
| title_fullStr | Paneth cells in farm animals: current status and future direction |
| title_full_unstemmed | Paneth cells in farm animals: current status and future direction |
| title_short | Paneth cells in farm animals: current status and future direction |
| title_sort | paneth cells in farm animals current status and future direction |
| topic | Antimicrobial peptide Farm animal Intestinal organoid Intestine Paneth cell |
| url | https://doi.org/10.1186/s40104-023-00905-5 |
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