Metabolomic analyses uncover an inhibitory effect of niclosamide on mitochondrial membrane potential in cholangiocarcinoma cells

Background Niclosamide is an oral anthelminthic drug that has been used for treating tapeworm infections. Its mechanism involves the disturbance of mitochondrial membrane potential that in turn inhibits oxidative phosphorylation leading to ATP depletion. To date, niclosamide has been validated as th...

Cur síos iomlán

Sonraí bibleagrafaíochta
Príomhchruthaitheoirí: Thanaporn Kulthawatsiri, Yingpinyapat Kittirat, Jutarop Phetcharaburanin, Jittima Tomacha, Bundit Promraksa, Arporn Wangwiwatsin, Poramate Klanrit, Attapol Titapun, Watcharin Loilome, Nisana Namwat
Formáid: Alt
Teanga:English
Foilsithe / Cruthaithe: PeerJ Inc. 2023-11-01
Sraith:PeerJ
Ábhair:
Rochtain ar líne:https://peerj.com/articles/16512.pdf