Association of periodontitis and oral microbiomes with Alzheimer’s disease: A narrative systematic review
Background/purpose: Alzheimer’s disease (AD) is a neurodegenerative disorder and the most common form of dementia. The etiology for AD includes age, genetic susceptibility, neuropathology, and infection. Periodontitis is an infectious and inflammatory disease which mainly causes alveolar bone destru...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-10-01
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| Series: | Journal of Dental Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1991790222001611 |
| _version_ | 1811237161145466880 |
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| author | Samantha Mao Chen-Pang Huang Hsin Lan Hing-Ger Lau Chun-Pin Chiang Yi-Wen Chen |
| author_facet | Samantha Mao Chen-Pang Huang Hsin Lan Hing-Ger Lau Chun-Pin Chiang Yi-Wen Chen |
| author_sort | Samantha Mao |
| collection | DOAJ |
| description | Background/purpose: Alzheimer’s disease (AD) is a neurodegenerative disorder and the most common form of dementia. The etiology for AD includes age, genetic susceptibility, neuropathology, and infection. Periodontitis is an infectious and inflammatory disease which mainly causes alveolar bone destruction and tooth loss. The evidence of a link between AD and periodontitis remains controversial. Thus far, studies reviewing the association between AD and periodontal disease have been insufficient from the viewpoint of the oral microbiome. The aim of this review was to focus on studies that have explored the relationship between the oral microbiome and AD development by using the next-generation sequencing technique. Materials and methods: A comprehensive electronic search of MEDLINE via PubMed, EMBASE, Scopus, and Google Scholar was conducted. The keywords included dementia, Alzheimer’s disease, cognitive impairment, periodontitis, periodontal disease, and oral microbiome. Results: This review included 26 articles based on the eligibility criteria. Epidemiologic researches and post-mortem studies showed that the presence of periodontitis is associated with cognitive decline, suggesting a possible role of periodontal pathogens in the pathogenesis of AD. The reported microbiome was inconsistent with those in gene sequencing studies. Nevertheless, Gram-negative species may be possible candidates. Conclusion: This review suggests that periodontal infection is associated with AD. The contributing microbiome remains unconfirmed, possibly because of different microbiome sampling sites or methods. Additional large-scale studies with periodontal intervention and longitudinal follow-up are warranted to clarify the relationship between periodontal disease and AD. |
| first_indexed | 2024-04-12T12:21:21Z |
| format | Article |
| id | doaj.art-b367c5276ff54481927d9901315ddd6d |
| institution | Directory Open Access Journal |
| issn | 1991-7902 |
| language | English |
| last_indexed | 2024-04-12T12:21:21Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Dental Sciences |
| spelling | doaj.art-b367c5276ff54481927d9901315ddd6d2022-12-22T03:33:18ZengElsevierJournal of Dental Sciences1991-79022022-10-0117417621779Association of periodontitis and oral microbiomes with Alzheimer’s disease: A narrative systematic reviewSamantha Mao0Chen-Pang Huang1Hsin Lan2Hing-Ger Lau3Chun-Pin Chiang4Yi-Wen Chen5Department of Dentistry, Sijhih Cathay General Hospital, New Taipei City, TaiwanDepartment of Dentistry, En Chu Kong Hospital, New Taipei City, TaiwanDepartment of Dentistry, Sijhih Cathay General Hospital, New Taipei City, TaiwanDepartment of Dentistry, Sijhih Cathay General Hospital, New Taipei City, TaiwanDepartment of Dentistry, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Corresponding author. Department of Dentistry, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, No. 707, Section 3, Chung-Yang Road, Hualien, 970, Taiwan.Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Corresponding author. Department of Dentistry, National Taiwan University Hospital, No. 1 Chang-Te Street, Taipei 10048, Taiwan.Background/purpose: Alzheimer’s disease (AD) is a neurodegenerative disorder and the most common form of dementia. The etiology for AD includes age, genetic susceptibility, neuropathology, and infection. Periodontitis is an infectious and inflammatory disease which mainly causes alveolar bone destruction and tooth loss. The evidence of a link between AD and periodontitis remains controversial. Thus far, studies reviewing the association between AD and periodontal disease have been insufficient from the viewpoint of the oral microbiome. The aim of this review was to focus on studies that have explored the relationship between the oral microbiome and AD development by using the next-generation sequencing technique. Materials and methods: A comprehensive electronic search of MEDLINE via PubMed, EMBASE, Scopus, and Google Scholar was conducted. The keywords included dementia, Alzheimer’s disease, cognitive impairment, periodontitis, periodontal disease, and oral microbiome. Results: This review included 26 articles based on the eligibility criteria. Epidemiologic researches and post-mortem studies showed that the presence of periodontitis is associated with cognitive decline, suggesting a possible role of periodontal pathogens in the pathogenesis of AD. The reported microbiome was inconsistent with those in gene sequencing studies. Nevertheless, Gram-negative species may be possible candidates. Conclusion: This review suggests that periodontal infection is associated with AD. The contributing microbiome remains unconfirmed, possibly because of different microbiome sampling sites or methods. Additional large-scale studies with periodontal intervention and longitudinal follow-up are warranted to clarify the relationship between periodontal disease and AD.http://www.sciencedirect.com/science/article/pii/S1991790222001611Alzheimer’s diseaseCognitive impairmentPeriodontitisOral microbiome |
| spellingShingle | Samantha Mao Chen-Pang Huang Hsin Lan Hing-Ger Lau Chun-Pin Chiang Yi-Wen Chen Association of periodontitis and oral microbiomes with Alzheimer’s disease: A narrative systematic review Journal of Dental Sciences Alzheimer’s disease Cognitive impairment Periodontitis Oral microbiome |
| title | Association of periodontitis and oral microbiomes with Alzheimer’s disease: A narrative systematic review |
| title_full | Association of periodontitis and oral microbiomes with Alzheimer’s disease: A narrative systematic review |
| title_fullStr | Association of periodontitis and oral microbiomes with Alzheimer’s disease: A narrative systematic review |
| title_full_unstemmed | Association of periodontitis and oral microbiomes with Alzheimer’s disease: A narrative systematic review |
| title_short | Association of periodontitis and oral microbiomes with Alzheimer’s disease: A narrative systematic review |
| title_sort | association of periodontitis and oral microbiomes with alzheimer s disease a narrative systematic review |
| topic | Alzheimer’s disease Cognitive impairment Periodontitis Oral microbiome |
| url | http://www.sciencedirect.com/science/article/pii/S1991790222001611 |
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