Screening HIV-positive men who have sex with men for hepatitis C re-infection risk: is a single question on condom-use enough? A sensitivity analysis
Abstract Background Hepatitis C virus (HCV) is common in men who have sex with men (MSM) with HIV. The Swiss HCVree Trial targeted a micro-elimination by using a treat and counsel strategy. Self-reported condomless anal intercourse with non-steady partners was used as the selection criterion for par...
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| Format: | Article |
| Language: | English |
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BMC
2019-09-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | http://link.springer.com/article/10.1186/s12879-019-4456-7 |
| _version_ | 1818341431377395712 |
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| author | Patrizia Künzler-Heule Sandra Engberg Manuel Battegay Axel J. Schmidt Katharina Fierz Huyen Nguyen Agnes Kocher Christiana Nöstlinger Benjamin Hampel Marcel Stöckle Charles Béguelin Julie Delaloye Patrick Schmid Markus Flepp Mathieu Rougement Dominique Laurent Braun Jan Fehr Dunja Nicca the Swiss HIV Cohort Study (SHCS) |
| author_facet | Patrizia Künzler-Heule Sandra Engberg Manuel Battegay Axel J. Schmidt Katharina Fierz Huyen Nguyen Agnes Kocher Christiana Nöstlinger Benjamin Hampel Marcel Stöckle Charles Béguelin Julie Delaloye Patrick Schmid Markus Flepp Mathieu Rougement Dominique Laurent Braun Jan Fehr Dunja Nicca the Swiss HIV Cohort Study (SHCS) |
| author_sort | Patrizia Künzler-Heule |
| collection | DOAJ |
| description | Abstract Background Hepatitis C virus (HCV) is common in men who have sex with men (MSM) with HIV. The Swiss HCVree Trial targeted a micro-elimination by using a treat and counsel strategy. Self-reported condomless anal intercourse with non-steady partners was used as the selection criterion for participation in a counselling intervention designed to prevent HCV re-infection. The purpose of this study was to assess the ability of this criterion to identify men who engaged in other sexual risk behaviours associated with HCV re-infection. Methods Men who disclosed their sexual and drug- use behaviours during the prior 6 months, at study baseline, were included in the current study. Using a descriptive comparative study design, we explored self-reported sexual and drug-use risk behaviours, compared the odds of reporting each behaviour in men who reported and denied condomless anal intercourse with non-steady partners during the prior year and calculated the sensitivity/specificity (95% CI) of the screening question in relation to the other at-risk behaviours. Results Seventy-two (61%) of the 118 men meeting eligibity criteria reported condomless anal intercourse with non-steady partners during the prior year. Many also engaged in other potential HCV transmission risk behaviours, e.g., 52 (44%) had used drugs. In participants disclosing drug use, 44 (37%) reported sexualised drug use and 17 (14%) injected drugs. Unadjusted odds ratios (95% CI) for two well-known risk behaviours were 2.02 (0.80, 5.62) for fisting and 5.66 (1.49, 37.12) for injecting drug use. The odds ratio for sexualised drug use - a potential mediator for increased sexual risk taking - was 5.90 (2.44, 16.05). Condomless anal intercourse with non-steady partners showed varying sensitivity in relation to the other risk behaviours examined (66.7–88.2%). Conclusions Although condomless anal intercourse with non-steady partners was fairly sensitive in detecting other HCV relevant risk behaviours, using it as the only screening criterion could lead to missing a proportion of HIV-positive men at risk for HCV re-infection due to other behaviours. This work also points to the importance of providing access to behavioral interventions addressing other sexual and drug use practices as part of HCV treatment. Trial registration Clinical Trial Number: NCT02785666, 30.05.2016. |
| first_indexed | 2024-12-13T15:58:41Z |
| format | Article |
| id | doaj.art-b36916d5b366426cb53fc667589f8096 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-13T15:58:41Z |
| publishDate | 2019-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-b36916d5b366426cb53fc667589f80962022-12-21T23:39:15ZengBMCBMC Infectious Diseases1471-23342019-09-011911810.1186/s12879-019-4456-7Screening HIV-positive men who have sex with men for hepatitis C re-infection risk: is a single question on condom-use enough? A sensitivity analysisPatrizia Künzler-Heule0Sandra Engberg1Manuel Battegay2Axel J. Schmidt3Katharina Fierz4Huyen Nguyen5Agnes Kocher6Christiana Nöstlinger7Benjamin Hampel8Marcel Stöckle9Charles Béguelin10Julie Delaloye11Patrick Schmid12Markus Flepp13Mathieu Rougement14Dominique Laurent Braun15Jan Fehr16Dunja Nicca17the Swiss HIV Cohort Study (SHCS)Nursing Science, Department Public Health, Faculty of Medicine, University of BaselNursing Science, Department Public Health, Faculty of Medicine, University of BaselDivision of Infectious Diseases and Hospital Epidemiology, University Hospital BaselDivision of Infectious Diseases, Cantonal Hospital St. GallenZurich University of Applied Sciences (ZUAS)Division of Infectious Diseases and Hospital Epidemiology, University Hospital ZurichNursing Science, Department Public Health, Faculty of Medicine, University of BaselDepartment of Public Health, Institute of Tropical MedicineDivision of Infectious Diseases and Hospital Epidemiology, University Hospital ZurichDivision of Infectious Diseases and Hospital Epidemiology, University Hospital BaselDepartment of Infectious Diseases, Bern University Hospital and University of BernDepartment of Intensive Care Medicine, University of Lausanne and University HospitalDivision of Infectious Diseases, Cantonal Hospital St. GallenCenter for Infectious Diseases, Klinik im ParkPrimary Care Medicine Unit, University Hospital of GenevaDivision of Infectious Diseases and Hospital Epidemiology, University Hospital ZurichDivision of Infectious Diseases and Hospital Epidemiology, University Hospital ZurichNursing Science, Department Public Health, Faculty of Medicine, University of BaselAbstract Background Hepatitis C virus (HCV) is common in men who have sex with men (MSM) with HIV. The Swiss HCVree Trial targeted a micro-elimination by using a treat and counsel strategy. Self-reported condomless anal intercourse with non-steady partners was used as the selection criterion for participation in a counselling intervention designed to prevent HCV re-infection. The purpose of this study was to assess the ability of this criterion to identify men who engaged in other sexual risk behaviours associated with HCV re-infection. Methods Men who disclosed their sexual and drug- use behaviours during the prior 6 months, at study baseline, were included in the current study. Using a descriptive comparative study design, we explored self-reported sexual and drug-use risk behaviours, compared the odds of reporting each behaviour in men who reported and denied condomless anal intercourse with non-steady partners during the prior year and calculated the sensitivity/specificity (95% CI) of the screening question in relation to the other at-risk behaviours. Results Seventy-two (61%) of the 118 men meeting eligibity criteria reported condomless anal intercourse with non-steady partners during the prior year. Many also engaged in other potential HCV transmission risk behaviours, e.g., 52 (44%) had used drugs. In participants disclosing drug use, 44 (37%) reported sexualised drug use and 17 (14%) injected drugs. Unadjusted odds ratios (95% CI) for two well-known risk behaviours were 2.02 (0.80, 5.62) for fisting and 5.66 (1.49, 37.12) for injecting drug use. The odds ratio for sexualised drug use - a potential mediator for increased sexual risk taking - was 5.90 (2.44, 16.05). Condomless anal intercourse with non-steady partners showed varying sensitivity in relation to the other risk behaviours examined (66.7–88.2%). Conclusions Although condomless anal intercourse with non-steady partners was fairly sensitive in detecting other HCV relevant risk behaviours, using it as the only screening criterion could lead to missing a proportion of HIV-positive men at risk for HCV re-infection due to other behaviours. This work also points to the importance of providing access to behavioral interventions addressing other sexual and drug use practices as part of HCV treatment. Trial registration Clinical Trial Number: NCT02785666, 30.05.2016.http://link.springer.com/article/10.1186/s12879-019-4456-7HIVHepatitis C virusHomosexualityMaleSexual behaviorCondoms |
| spellingShingle | Patrizia Künzler-Heule Sandra Engberg Manuel Battegay Axel J. Schmidt Katharina Fierz Huyen Nguyen Agnes Kocher Christiana Nöstlinger Benjamin Hampel Marcel Stöckle Charles Béguelin Julie Delaloye Patrick Schmid Markus Flepp Mathieu Rougement Dominique Laurent Braun Jan Fehr Dunja Nicca the Swiss HIV Cohort Study (SHCS) Screening HIV-positive men who have sex with men for hepatitis C re-infection risk: is a single question on condom-use enough? A sensitivity analysis BMC Infectious Diseases HIV Hepatitis C virus Homosexuality Male Sexual behavior Condoms |
| title | Screening HIV-positive men who have sex with men for hepatitis C re-infection risk: is a single question on condom-use enough? A sensitivity analysis |
| title_full | Screening HIV-positive men who have sex with men for hepatitis C re-infection risk: is a single question on condom-use enough? A sensitivity analysis |
| title_fullStr | Screening HIV-positive men who have sex with men for hepatitis C re-infection risk: is a single question on condom-use enough? A sensitivity analysis |
| title_full_unstemmed | Screening HIV-positive men who have sex with men for hepatitis C re-infection risk: is a single question on condom-use enough? A sensitivity analysis |
| title_short | Screening HIV-positive men who have sex with men for hepatitis C re-infection risk: is a single question on condom-use enough? A sensitivity analysis |
| title_sort | screening hiv positive men who have sex with men for hepatitis c re infection risk is a single question on condom use enough a sensitivity analysis |
| topic | HIV Hepatitis C virus Homosexuality Male Sexual behavior Condoms |
| url | http://link.springer.com/article/10.1186/s12879-019-4456-7 |
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