Sleep-Wake and Circadian Disorders after Tick-Borne Encephalitis
Tick-borne encephalitis (TBE) is an infectious disease affecting the central nervous system. Recently, the occurrence of TBEV infections has steadily increased, reaching all-time high incidence rates in European countries. Up to 50% of patients with TBE present neurological sequelae, among them slee...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-01-01
|
| Series: | Microorganisms |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2607/10/2/304 |
| _version_ | 1797477877980069888 |
|---|---|
| author | Gabriele Chiffi Denis Grandgirard Parham Sendi Anelia Dietmann Claudio L. A. Bassetti Stephen L. Leib |
| author_facet | Gabriele Chiffi Denis Grandgirard Parham Sendi Anelia Dietmann Claudio L. A. Bassetti Stephen L. Leib |
| author_sort | Gabriele Chiffi |
| collection | DOAJ |
| description | Tick-borne encephalitis (TBE) is an infectious disease affecting the central nervous system. Recently, the occurrence of TBEV infections has steadily increased, reaching all-time high incidence rates in European countries. Up to 50% of patients with TBE present neurological sequelae, among them sleep–wake and circadian disorders (SWCD), which are poorly characterized. The aim of this review is to investigate the prevalence, clinical characteristics, and prognosis of SWCD after TBE. The literature review was performed in accordance with PRISMA guidelines. The quality of the paper was assessed using a standardized quality assessment. The analysis of SWCD was categorized into four different time intervals and two age groups. The literature search identified 15 studies, five including children and 10 including adults. In children, fatigue was most frequently observed with a prevalence of 73.9%, followed by somnolence/sleepiness, restlessness, and sleep-wake inversion. In adults, tiredness/fatigue was the most reported sequela with a prevalence of 27.4%, followed by extensive daytime sleepiness/somnolence, and insomnia (3.3%). Two studies showed impaired social outcomes in patients after TBE infections. SWCD after TBE in children and adults is a newly recognized sequela. Additional clinical and experimental research is needed to gain more precise insight into the clinical burden of SWCD after TBE and the underlying mechanisms. |
| first_indexed | 2024-03-09T21:23:59Z |
| format | Article |
| id | doaj.art-b3693cef2b7d44b8a02db48489b4f1d5 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-09T21:23:59Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-b3693cef2b7d44b8a02db48489b4f1d52023-11-23T21:14:02ZengMDPI AGMicroorganisms2076-26072022-01-0110230410.3390/microorganisms10020304Sleep-Wake and Circadian Disorders after Tick-Borne EncephalitisGabriele Chiffi0Denis Grandgirard1Parham Sendi2Anelia Dietmann3Claudio L. A. Bassetti4Stephen L. Leib5Institute for Infectious Diseases, University of Bern, 3001 Bern, SwitzerlandInstitute for Infectious Diseases, University of Bern, 3001 Bern, SwitzerlandInstitute for Infectious Diseases, University of Bern, 3001 Bern, SwitzerlandDepartment of Neurology, Bern University Hospital, University of Bern, 3010 Bern, SwitzerlandDepartment of Neurology, Bern University Hospital, University of Bern, 3010 Bern, SwitzerlandInstitute for Infectious Diseases, University of Bern, 3001 Bern, SwitzerlandTick-borne encephalitis (TBE) is an infectious disease affecting the central nervous system. Recently, the occurrence of TBEV infections has steadily increased, reaching all-time high incidence rates in European countries. Up to 50% of patients with TBE present neurological sequelae, among them sleep–wake and circadian disorders (SWCD), which are poorly characterized. The aim of this review is to investigate the prevalence, clinical characteristics, and prognosis of SWCD after TBE. The literature review was performed in accordance with PRISMA guidelines. The quality of the paper was assessed using a standardized quality assessment. The analysis of SWCD was categorized into four different time intervals and two age groups. The literature search identified 15 studies, five including children and 10 including adults. In children, fatigue was most frequently observed with a prevalence of 73.9%, followed by somnolence/sleepiness, restlessness, and sleep-wake inversion. In adults, tiredness/fatigue was the most reported sequela with a prevalence of 27.4%, followed by extensive daytime sleepiness/somnolence, and insomnia (3.3%). Two studies showed impaired social outcomes in patients after TBE infections. SWCD after TBE in children and adults is a newly recognized sequela. Additional clinical and experimental research is needed to gain more precise insight into the clinical burden of SWCD after TBE and the underlying mechanisms.https://www.mdpi.com/2076-2607/10/2/304tick-borne encephalitissleep-wake circadian disorderschildrenadultslong-term sequelafatigue |
| spellingShingle | Gabriele Chiffi Denis Grandgirard Parham Sendi Anelia Dietmann Claudio L. A. Bassetti Stephen L. Leib Sleep-Wake and Circadian Disorders after Tick-Borne Encephalitis Microorganisms tick-borne encephalitis sleep-wake circadian disorders children adults long-term sequela fatigue |
| title | Sleep-Wake and Circadian Disorders after Tick-Borne Encephalitis |
| title_full | Sleep-Wake and Circadian Disorders after Tick-Borne Encephalitis |
| title_fullStr | Sleep-Wake and Circadian Disorders after Tick-Borne Encephalitis |
| title_full_unstemmed | Sleep-Wake and Circadian Disorders after Tick-Borne Encephalitis |
| title_short | Sleep-Wake and Circadian Disorders after Tick-Borne Encephalitis |
| title_sort | sleep wake and circadian disorders after tick borne encephalitis |
| topic | tick-borne encephalitis sleep-wake circadian disorders children adults long-term sequela fatigue |
| url | https://www.mdpi.com/2076-2607/10/2/304 |
| work_keys_str_mv | AT gabrielechiffi sleepwakeandcircadiandisordersaftertickborneencephalitis AT denisgrandgirard sleepwakeandcircadiandisordersaftertickborneencephalitis AT parhamsendi sleepwakeandcircadiandisordersaftertickborneencephalitis AT aneliadietmann sleepwakeandcircadiandisordersaftertickborneencephalitis AT claudiolabassetti sleepwakeandcircadiandisordersaftertickborneencephalitis AT stephenlleib sleepwakeandcircadiandisordersaftertickborneencephalitis |