Hyperbaric oxygen therapy for hemorrhagic radiation cystitis
Background: Radiation cystitis with macroscopic hematuria is a frustrating clinical problem for urologists. Since 1985, hyperbaric oxygen therapy (HBOT) has been applied as a treatment for radiation cystitis with macroscopic hematuria; numerous studies have shown that this treatment has favorable re...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Health/LWW
2017-01-01
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| Series: | Formosan Journal of Surgery |
| Subjects: | |
| Online Access: | http://www.e-fjs.org/article.asp?issn=1682-606X;year=2017;volume=50;issue=2;spage=52;epage=56;aulast=Lin |
| _version_ | 1797706475208966144 |
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| author | Kung-Hung Lin Hui-Chieh Lee Wen-Shyan Huang Po-Wei Huang Seng-Chung Ke Man-Gang Lee |
| author_facet | Kung-Hung Lin Hui-Chieh Lee Wen-Shyan Huang Po-Wei Huang Seng-Chung Ke Man-Gang Lee |
| author_sort | Kung-Hung Lin |
| collection | DOAJ |
| description | Background: Radiation cystitis with macroscopic hematuria is a frustrating clinical problem for urologists. Since 1985, hyperbaric oxygen therapy (HBOT) has been applied as a treatment for radiation cystitis with macroscopic hematuria; numerous studies have shown that this treatment has favorable results.
Purpose: The purpose of this study was to elucidate the HBOT affected the clinical outcomes and treatment of hemorrhagic radiation cystitis (HRC).
Methods: Between November 1989 and June 2014, 42 patients (39 women and three men) with HRC were treated with hyperbaric oxygen at a pressure of 2.5 atmospheres absolute, breathing 100% O2for 120 min in a multiplace hyperbaric chamber.
Results: After an average of 38 hyperbaric oxygen sessions, macroscopic hematuria was completely halted in 35 patients (83.3%) and markedly decreased in three patients (7.1%). A comparison of cystoscopic findings before and after HBOT showed significant decreases in both hemorrhagic sites and telangiectasis of the bladder mucosa. The mean follow-up was 20.7 months (range: 3–49 months). No cases exhibited evidence of barotrauma or oxygen toxicity. One patient underwent a urodynamic study both before and after HBOT, with several changes in bladder function observed after HBOT: urine peak flow increased from 12.8 mL/s before HBOT to 15.0 mL/s after HBOT and urine mean flow increased from 6.5 mL/s to 8.9 mL/s. Urine voiding time decreased from 40.0 s to 28.0 s, urine flow time from 39.0 s to 28.0 s, time to peak flow from 15.0 s to 8.0 s, and voided volume from 251 mL to 248 mL.
Conclusion: The results of this study suggest that early application of HBOT is a safe and effective treatment method for HRC. Whether HBOT is beneficial to urinary bladder function requires further study with a larger patient cohort enrolled. |
| first_indexed | 2024-03-12T05:51:48Z |
| format | Article |
| id | doaj.art-b369e844539e4e6c9ac88a4927e02735 |
| institution | Directory Open Access Journal |
| issn | 1682-606X |
| language | English |
| last_indexed | 2024-03-12T05:51:48Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Health/LWW |
| record_format | Article |
| series | Formosan Journal of Surgery |
| spelling | doaj.art-b369e844539e4e6c9ac88a4927e027352023-09-03T05:03:19ZengWolters Kluwer Health/LWWFormosan Journal of Surgery1682-606X2017-01-01502525610.4103/fjs.fjs_19_17Hyperbaric oxygen therapy for hemorrhagic radiation cystitisKung-Hung LinHui-Chieh LeeWen-Shyan HuangPo-Wei HuangSeng-Chung KeMan-Gang LeeBackground: Radiation cystitis with macroscopic hematuria is a frustrating clinical problem for urologists. Since 1985, hyperbaric oxygen therapy (HBOT) has been applied as a treatment for radiation cystitis with macroscopic hematuria; numerous studies have shown that this treatment has favorable results. Purpose: The purpose of this study was to elucidate the HBOT affected the clinical outcomes and treatment of hemorrhagic radiation cystitis (HRC). Methods: Between November 1989 and June 2014, 42 patients (39 women and three men) with HRC were treated with hyperbaric oxygen at a pressure of 2.5 atmospheres absolute, breathing 100% O2for 120 min in a multiplace hyperbaric chamber. Results: After an average of 38 hyperbaric oxygen sessions, macroscopic hematuria was completely halted in 35 patients (83.3%) and markedly decreased in three patients (7.1%). A comparison of cystoscopic findings before and after HBOT showed significant decreases in both hemorrhagic sites and telangiectasis of the bladder mucosa. The mean follow-up was 20.7 months (range: 3–49 months). No cases exhibited evidence of barotrauma or oxygen toxicity. One patient underwent a urodynamic study both before and after HBOT, with several changes in bladder function observed after HBOT: urine peak flow increased from 12.8 mL/s before HBOT to 15.0 mL/s after HBOT and urine mean flow increased from 6.5 mL/s to 8.9 mL/s. Urine voiding time decreased from 40.0 s to 28.0 s, urine flow time from 39.0 s to 28.0 s, time to peak flow from 15.0 s to 8.0 s, and voided volume from 251 mL to 248 mL. Conclusion: The results of this study suggest that early application of HBOT is a safe and effective treatment method for HRC. Whether HBOT is beneficial to urinary bladder function requires further study with a larger patient cohort enrolled.http://www.e-fjs.org/article.asp?issn=1682-606X;year=2017;volume=50;issue=2;spage=52;epage=56;aulast=LinHemorrhagic radiation cystitishyperbaric oxygen therapyurodynamic |
| spellingShingle | Kung-Hung Lin Hui-Chieh Lee Wen-Shyan Huang Po-Wei Huang Seng-Chung Ke Man-Gang Lee Hyperbaric oxygen therapy for hemorrhagic radiation cystitis Formosan Journal of Surgery Hemorrhagic radiation cystitis hyperbaric oxygen therapy urodynamic |
| title | Hyperbaric oxygen therapy for hemorrhagic radiation cystitis |
| title_full | Hyperbaric oxygen therapy for hemorrhagic radiation cystitis |
| title_fullStr | Hyperbaric oxygen therapy for hemorrhagic radiation cystitis |
| title_full_unstemmed | Hyperbaric oxygen therapy for hemorrhagic radiation cystitis |
| title_short | Hyperbaric oxygen therapy for hemorrhagic radiation cystitis |
| title_sort | hyperbaric oxygen therapy for hemorrhagic radiation cystitis |
| topic | Hemorrhagic radiation cystitis hyperbaric oxygen therapy urodynamic |
| url | http://www.e-fjs.org/article.asp?issn=1682-606X;year=2017;volume=50;issue=2;spage=52;epage=56;aulast=Lin |
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