Epac1 Is Crucial for Maintenance of Endothelial Barrier Function through A Mechanism Partly Independent of Rac1

Epac1 Is Crucial for Maintenance of Endothelial Barrier Function through A Mechanism Partly Independent of Rac1

Epac1 (exchange protein activated by cAMP) stabilizes the endothelial barrier, but detailed studies are limited by the side effects of pharmacological Epac1 modulators and transient transfections. Here, we compare the key properties of barriers between endothelial cells derived from wild-type (WT) a...

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Bibliographic Details
Main Authors: Alexander García-Ponce, Katharina Schuster, Stein-Ove Døskeland, Rolf K. Reed, Fitz-Roy E. Curry, Jens Waschke, Mariya Y. Radeva
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cells
Subjects:
cAMP
endothelial barrier
Epac1
Rho GTPases
Online Access:https://www.mdpi.com/2073-4409/9/10/2170

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