Immune-Mediated Fever in the Dog. Occurrence of Antinuclear Antibodies, Rheumatoid Factor, Tumor Necrosis Factor and Interleukin-6 in Serum
<p/> <p>Contents of antinuclear antibodies (ANA), rheumatoid factor (RF), tumor necrosis factor (TNF-α) and interleukin-6 (IL-6) were measured in serum from 20 dogs with immune-mediated fever. Seven out of 20 patients were ANA positive, 1 out of 20 was positive to antibodies against extr...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2002-09-01
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| Series: | Acta Veterinaria Scandinavica |
| Subjects: | |
| Online Access: | http://www.actavetscand.com/content/43/3/165 |
| _version_ | 1818113570514141184 |
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| author | Moen Torolf Hanssen I Bohnhorst Øvrebø |
| author_facet | Moen Torolf Hanssen I Bohnhorst Øvrebø |
| author_sort | Moen Torolf |
| collection | DOAJ |
| description | <p/> <p>Contents of antinuclear antibodies (ANA), rheumatoid factor (RF), tumor necrosis factor (TNF-α) and interleukin-6 (IL-6) were measured in serum from 20 dogs with immune-mediated fever. Seven out of 20 patients were ANA positive, 1 out of 20 was positive to antibodies against extractable nuclear antigens (ENA), 1 out of 20 was positive to antibodies against deoxynucleoproteins (DNP), 2 out of 13 were RF positive and none out of 20 patients had antibodies against native DNA in the serum. TNF-α was not detected in any serum of 15 dogs with immune-mediated fever, while 10 out of 13 presented with elevated IL-6. The results varied between patients, but the IL-6 level was high in most of them. This indicate a role for IL-6 in the pathogenesis of immune-mediated fever in most cases.</p> |
| first_indexed | 2024-12-11T03:36:56Z |
| format | Article |
| id | doaj.art-b36ed5a4baf442d0b302356d0e9d8545 |
| institution | Directory Open Access Journal |
| issn | 1751-0147 |
| language | English |
| last_indexed | 2024-12-11T03:36:56Z |
| publishDate | 2002-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Acta Veterinaria Scandinavica |
| spelling | doaj.art-b36ed5a4baf442d0b302356d0e9d85452022-12-22T01:22:14ZengBMCActa Veterinaria Scandinavica1751-01472002-09-0143316517110.1186/1751-0147-43-165Immune-Mediated Fever in the Dog. Occurrence of Antinuclear Antibodies, Rheumatoid Factor, Tumor Necrosis Factor and Interleukin-6 in SerumMoen TorolfHanssen IBohnhorst Øvrebø<p/> <p>Contents of antinuclear antibodies (ANA), rheumatoid factor (RF), tumor necrosis factor (TNF-α) and interleukin-6 (IL-6) were measured in serum from 20 dogs with immune-mediated fever. Seven out of 20 patients were ANA positive, 1 out of 20 was positive to antibodies against extractable nuclear antigens (ENA), 1 out of 20 was positive to antibodies against deoxynucleoproteins (DNP), 2 out of 13 were RF positive and none out of 20 patients had antibodies against native DNA in the serum. TNF-α was not detected in any serum of 15 dogs with immune-mediated fever, while 10 out of 13 presented with elevated IL-6. The results varied between patients, but the IL-6 level was high in most of them. This indicate a role for IL-6 in the pathogenesis of immune-mediated fever in most cases.</p>http://www.actavetscand.com/content/43/3/165dogimmunefeverantinuclear antibodiesrheumatoid factortumor necrosis factorinterleukin-6. |
| spellingShingle | Moen Torolf Hanssen I Bohnhorst Øvrebø Immune-Mediated Fever in the Dog. Occurrence of Antinuclear Antibodies, Rheumatoid Factor, Tumor Necrosis Factor and Interleukin-6 in Serum Acta Veterinaria Scandinavica dog immune fever antinuclear antibodies rheumatoid factor tumor necrosis factor interleukin-6. |
| title | Immune-Mediated Fever in the Dog. Occurrence of Antinuclear Antibodies, Rheumatoid Factor, Tumor Necrosis Factor and Interleukin-6 in Serum |
| title_full | Immune-Mediated Fever in the Dog. Occurrence of Antinuclear Antibodies, Rheumatoid Factor, Tumor Necrosis Factor and Interleukin-6 in Serum |
| title_fullStr | Immune-Mediated Fever in the Dog. Occurrence of Antinuclear Antibodies, Rheumatoid Factor, Tumor Necrosis Factor and Interleukin-6 in Serum |
| title_full_unstemmed | Immune-Mediated Fever in the Dog. Occurrence of Antinuclear Antibodies, Rheumatoid Factor, Tumor Necrosis Factor and Interleukin-6 in Serum |
| title_short | Immune-Mediated Fever in the Dog. Occurrence of Antinuclear Antibodies, Rheumatoid Factor, Tumor Necrosis Factor and Interleukin-6 in Serum |
| title_sort | immune mediated fever in the dog occurrence of antinuclear antibodies rheumatoid factor tumor necrosis factor and interleukin 6 in serum |
| topic | dog immune fever antinuclear antibodies rheumatoid factor tumor necrosis factor interleukin-6. |
| url | http://www.actavetscand.com/content/43/3/165 |
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