Whole-Genome Sequence Approach and Phylogenomic Stratification Improve the Association Analysis of Mutations With Patient Data in Influenza Surveillance

Whole-Genome Sequence Approach and Phylogenomic Stratification Improve the Association Analysis of Mutations With Patient Data in Influenza Surveillance

Each year, seasonal influenza results in high mortality and morbidity. The current classification of circulating influenza viruses is mainly focused on the hemagglutinin gene. Whole-genome sequencing (WGS) enables tracking mutations across all influenza segments allowing a better understanding of th...

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Bibliographic Details
Main Authors: Laura Van Poelvoorde, Kevin Vanneste, Sigrid C. J. De Keersmaecker, Isabelle Thomas, Nina Van Goethem, Steven Van Gucht, Xavier Saelens, Nancy H. C. Roosens
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Microbiology
Subjects:
influenza
surveillance
mutations
Nextstrain
next-generation sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.809887/full

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