Mitochondrial H2O2 release does not directly cause damage to chromosomal DNA

Mitochondrial H2O2 release does not directly cause damage to chromosomal DNA

Abstract Reactive Oxygen Species (ROS) derived from mitochondrial respiration are frequently cited as a major source of chromosomal DNA mutations that contribute to cancer development and aging. However, experimental evidence showing that ROS released by mitochondria can directly damage nuclear DNA...

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Bibliographic Details
Main Authors: Daan M. K. van Soest, Paulien E. Polderman, Wytze T. F. den Toom, Janneke P. Keijer, Markus J. van Roosmalen, Tim M. F. Leyten, Johannes Lehmann, Susan Zwakenberg, Sasha De Henau, Ruben van Boxtel, Boudewijn M. T. Burgering, Tobias B. Dansen
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-47008-x

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