The neutrophil-to-lymphocyte ratio is associated with mild cognitive impairment in community-dwelling older women aged over 70 years: a population-based cross-sectional study
BackgroundThe neutrophil-to-lymphocyte ratio (NLR) is a marker of inflammation that can be obtained quickly, conveniently, and cheaply from blood samples. However, there is no research to explore the effects of sex and age on the relationship between the NLR and mild cognitive impairment (MCI) in co...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1261026/full |
| _version_ | 1797661869346914304 |
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| author | Shengjie Li Shengjie Li Xiaoyu Chen Mengze Gao Mengze Gao Xingyu Zhang Xingyu Zhang Peipei Han Liou Cao Jing Gao Qiongying Tao Jiayi Zhai Dongyu Liang Qi Guo |
| author_facet | Shengjie Li Shengjie Li Xiaoyu Chen Mengze Gao Mengze Gao Xingyu Zhang Xingyu Zhang Peipei Han Liou Cao Jing Gao Qiongying Tao Jiayi Zhai Dongyu Liang Qi Guo |
| author_sort | Shengjie Li |
| collection | DOAJ |
| description | BackgroundThe neutrophil-to-lymphocyte ratio (NLR) is a marker of inflammation that can be obtained quickly, conveniently, and cheaply from blood samples. However, there is no research to explore the effects of sex and age on the relationship between the NLR and mild cognitive impairment (MCI) in community-dwelling older adults.MethodsA total of 3,169 individuals aged over 60 years in Shanghai were recruited for face-to-face interviews, and blood samples were collected. MCI was assessed by the Mini-Mental State Examination (MMSE) and the Instrumental Activities of Daily Living (IADL) scale, and neutrophil count and lymphocyte counts were measured in fasting blood samples. The NLR was calculated by dividing the absolute neutrophil count by the absolute lymphocyte count.ResultsIn females, the NLR in the MCI group was significantly higher than that in the cognitively normal group (2.13 ± 0.94 vs. 1.85 ± 0.83, p < 0.001) but not in men. Logistic regression showed that a higher NLR was an independent risk factor for MCI in women [odds ratio (OR) = 1.28; 95% confidence interval (CI) = 1.09–1.49]. In addition, the elevated NLR quartile was associated with an increased risk of MCI, especially in women older than 70 years (p-value for trend = 0.011).ConclusionCompared with males, female MCI patients had a significantly higher NLR than cognitively normal controls. In addition, elevated NLR was found to be significantly associated with MCI risk in women older than 70 years. Therefore, elderly Chinese women with a higher NLR value may be the target population for effective prevention of MCI. |
| first_indexed | 2024-03-11T18:51:03Z |
| format | Article |
| id | doaj.art-b371f5564d89412cb97b3dbe2a12a383 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-03-11T18:51:03Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-b371f5564d89412cb97b3dbe2a12a3832023-10-11T11:11:24ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652023-09-011510.3389/fnagi.2023.12610261261026The neutrophil-to-lymphocyte ratio is associated with mild cognitive impairment in community-dwelling older women aged over 70 years: a population-based cross-sectional studyShengjie Li0Shengjie Li1Xiaoyu Chen2Mengze Gao3Mengze Gao4Xingyu Zhang5Xingyu Zhang6Peipei Han7Liou Cao8Jing Gao9Qiongying Tao10Jiayi Zhai11Dongyu Liang12Qi Guo13Department of Rehabilitation Medicine, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai, ChinaSchool of Sports and Health, Tianjin University of Sport, Tianjin, ChinaDepartment of Rehabilitation Medicine, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai, ChinaDepartment of Rehabilitation Medicine, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai, ChinaSchool of Sports and Health, Tianjin University of Sport, Tianjin, ChinaDepartment of Rehabilitation Medicine, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai, ChinaSchool of Sports and Health, Tianjin University of Sport, Tianjin, ChinaDepartment of Rehabilitation Medicine, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai, ChinaDepartment of Nephrology, Molecular Cell Lab for Kidney Disease, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaGeneral Practice Clinic, Pujiang Community Health Service Center in Minhang District, Shanghai, ChinaJiading Subdistrict Community Health Center, Shanghai, ChinaJiading Subdistrict Community Health Center, Shanghai, ChinaClinical Research Center, Jiading District Central Hospital Affiliated Shanghai University of Medicine and Health Sciences, Shanghai, ChinaDepartment of Rehabilitation Medicine, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai, ChinaBackgroundThe neutrophil-to-lymphocyte ratio (NLR) is a marker of inflammation that can be obtained quickly, conveniently, and cheaply from blood samples. However, there is no research to explore the effects of sex and age on the relationship between the NLR and mild cognitive impairment (MCI) in community-dwelling older adults.MethodsA total of 3,169 individuals aged over 60 years in Shanghai were recruited for face-to-face interviews, and blood samples were collected. MCI was assessed by the Mini-Mental State Examination (MMSE) and the Instrumental Activities of Daily Living (IADL) scale, and neutrophil count and lymphocyte counts were measured in fasting blood samples. The NLR was calculated by dividing the absolute neutrophil count by the absolute lymphocyte count.ResultsIn females, the NLR in the MCI group was significantly higher than that in the cognitively normal group (2.13 ± 0.94 vs. 1.85 ± 0.83, p < 0.001) but not in men. Logistic regression showed that a higher NLR was an independent risk factor for MCI in women [odds ratio (OR) = 1.28; 95% confidence interval (CI) = 1.09–1.49]. In addition, the elevated NLR quartile was associated with an increased risk of MCI, especially in women older than 70 years (p-value for trend = 0.011).ConclusionCompared with males, female MCI patients had a significantly higher NLR than cognitively normal controls. In addition, elevated NLR was found to be significantly associated with MCI risk in women older than 70 years. Therefore, elderly Chinese women with a higher NLR value may be the target population for effective prevention of MCI.https://www.frontiersin.org/articles/10.3389/fnagi.2023.1261026/fullinflammationsmild cognitive impairmentsex differencepopulation-based studyneutrophil-to-lymphocyte ratio (NLR) |
| spellingShingle | Shengjie Li Shengjie Li Xiaoyu Chen Mengze Gao Mengze Gao Xingyu Zhang Xingyu Zhang Peipei Han Liou Cao Jing Gao Qiongying Tao Jiayi Zhai Dongyu Liang Qi Guo The neutrophil-to-lymphocyte ratio is associated with mild cognitive impairment in community-dwelling older women aged over 70 years: a population-based cross-sectional study Frontiers in Aging Neuroscience inflammations mild cognitive impairment sex difference population-based study neutrophil-to-lymphocyte ratio (NLR) |
| title | The neutrophil-to-lymphocyte ratio is associated with mild cognitive impairment in community-dwelling older women aged over 70 years: a population-based cross-sectional study |
| title_full | The neutrophil-to-lymphocyte ratio is associated with mild cognitive impairment in community-dwelling older women aged over 70 years: a population-based cross-sectional study |
| title_fullStr | The neutrophil-to-lymphocyte ratio is associated with mild cognitive impairment in community-dwelling older women aged over 70 years: a population-based cross-sectional study |
| title_full_unstemmed | The neutrophil-to-lymphocyte ratio is associated with mild cognitive impairment in community-dwelling older women aged over 70 years: a population-based cross-sectional study |
| title_short | The neutrophil-to-lymphocyte ratio is associated with mild cognitive impairment in community-dwelling older women aged over 70 years: a population-based cross-sectional study |
| title_sort | neutrophil to lymphocyte ratio is associated with mild cognitive impairment in community dwelling older women aged over 70 years a population based cross sectional study |
| topic | inflammations mild cognitive impairment sex difference population-based study neutrophil-to-lymphocyte ratio (NLR) |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1261026/full |
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