Outcomes in the Treatment of Subretinal Macular Hemorrhage Secondary to Age-Related Macular Degeneration: A Systematic Review
<b>Background</b>: Subretinal macular hemorrhage (SRMH) secondary to age-related macular degeneration (AMD) is a relatively rare condition in ophthalmology characterized by blood collection between the neurosensory retina and the retinal pigment epithelium (RPE). Without prompt treatment...
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MDPI AG
2024-01-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/13/2/367 |
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| author | Filippo Confalonieri Vanessa Ferraro Gianmaria Barone Alessandra Di Maria Beáta Éva Petrovski Josè Luis Vallejo Garcia Alessandro Randazzo Paolo Vinciguerra Xhevat Lumi Goran Petrovski |
| author_facet | Filippo Confalonieri Vanessa Ferraro Gianmaria Barone Alessandra Di Maria Beáta Éva Petrovski Josè Luis Vallejo Garcia Alessandro Randazzo Paolo Vinciguerra Xhevat Lumi Goran Petrovski |
| author_sort | Filippo Confalonieri |
| collection | DOAJ |
| description | <b>Background</b>: Subretinal macular hemorrhage (SRMH) secondary to age-related macular degeneration (AMD) is a relatively rare condition in ophthalmology characterized by blood collection between the neurosensory retina and the retinal pigment epithelium (RPE). Without prompt treatment, visual prognosis is poor. A plethora of treatment approaches have been tried over the past years ranging from intravitreal anti-vascular endothelial growth factor (anti-VEGF) monotherapy to direct subretinal surgery, with no conclusive superiority of one over the other. <b>Materials and Methods</b>: We conducted a systematic review of the outcomes and treatment modalities of SRMH from inception to 14 June 2022, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PRISMA). The level of evidence was assessed for all included articles according to the quality of evidence according to the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. <b>Results</b>: A total of 2745 articles were initially extracted, out of which 1654 articles were obtained after duplicates were removed and their abstracts screened. A total of 155 articles were included for full-text review. Finally, 81 articles remained that fulfilled the inclusion criteria. <b>Conclusions</b>: Even though there are solid results supporting a variety of treatments for SRMH, the best treatment modality has still not been conclusively demonstrated and further research is needed. |
| first_indexed | 2024-03-08T09:52:13Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-08T09:52:13Z |
| publishDate | 2024-01-01 |
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| series | Journal of Clinical Medicine |
| spelling | doaj.art-b3724c57a0a241fc876f5ade9713c3862024-01-29T14:01:11ZengMDPI AGJournal of Clinical Medicine2077-03832024-01-0113236710.3390/jcm13020367Outcomes in the Treatment of Subretinal Macular Hemorrhage Secondary to Age-Related Macular Degeneration: A Systematic ReviewFilippo Confalonieri0Vanessa Ferraro1Gianmaria Barone2Alessandra Di Maria3Beáta Éva Petrovski4Josè Luis Vallejo Garcia5Alessandro Randazzo6Paolo Vinciguerra7Xhevat Lumi8Goran Petrovski9Department of Ophthalmology, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, ItalyDepartment of Ophthalmology, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, ItalyDepartment of Ophthalmology, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, ItalyDepartment of Ophthalmology, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, ItalyCenter for Eye Research and Innovative Diagnostics, Department of Ophthalmology, Institute for Clinical Medicine, University of Oslo, Kirkeveien 166, 0450 Oslo, NorwayDepartment of Ophthalmology, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, ItalyDepartment of Ophthalmology, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, ItalyDepartment of Ophthalmology, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, ItalyCenter for Eye Research and Innovative Diagnostics, Department of Ophthalmology, Institute for Clinical Medicine, University of Oslo, Kirkeveien 166, 0450 Oslo, NorwayCenter for Eye Research and Innovative Diagnostics, Department of Ophthalmology, Institute for Clinical Medicine, University of Oslo, Kirkeveien 166, 0450 Oslo, Norway<b>Background</b>: Subretinal macular hemorrhage (SRMH) secondary to age-related macular degeneration (AMD) is a relatively rare condition in ophthalmology characterized by blood collection between the neurosensory retina and the retinal pigment epithelium (RPE). Without prompt treatment, visual prognosis is poor. A plethora of treatment approaches have been tried over the past years ranging from intravitreal anti-vascular endothelial growth factor (anti-VEGF) monotherapy to direct subretinal surgery, with no conclusive superiority of one over the other. <b>Materials and Methods</b>: We conducted a systematic review of the outcomes and treatment modalities of SRMH from inception to 14 June 2022, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PRISMA). The level of evidence was assessed for all included articles according to the quality of evidence according to the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. <b>Results</b>: A total of 2745 articles were initially extracted, out of which 1654 articles were obtained after duplicates were removed and their abstracts screened. A total of 155 articles were included for full-text review. Finally, 81 articles remained that fulfilled the inclusion criteria. <b>Conclusions</b>: Even though there are solid results supporting a variety of treatments for SRMH, the best treatment modality has still not been conclusively demonstrated and further research is needed.https://www.mdpi.com/2077-0383/13/2/367subretinal macular hemorrhage (SRMH)age-related macular degeneration (AMD)vitreoretinal surgeryrecombinant tissue plasminogen activator (rt-PA) |
| spellingShingle | Filippo Confalonieri Vanessa Ferraro Gianmaria Barone Alessandra Di Maria Beáta Éva Petrovski Josè Luis Vallejo Garcia Alessandro Randazzo Paolo Vinciguerra Xhevat Lumi Goran Petrovski Outcomes in the Treatment of Subretinal Macular Hemorrhage Secondary to Age-Related Macular Degeneration: A Systematic Review Journal of Clinical Medicine subretinal macular hemorrhage (SRMH) age-related macular degeneration (AMD) vitreoretinal surgery recombinant tissue plasminogen activator (rt-PA) |
| title | Outcomes in the Treatment of Subretinal Macular Hemorrhage Secondary to Age-Related Macular Degeneration: A Systematic Review |
| title_full | Outcomes in the Treatment of Subretinal Macular Hemorrhage Secondary to Age-Related Macular Degeneration: A Systematic Review |
| title_fullStr | Outcomes in the Treatment of Subretinal Macular Hemorrhage Secondary to Age-Related Macular Degeneration: A Systematic Review |
| title_full_unstemmed | Outcomes in the Treatment of Subretinal Macular Hemorrhage Secondary to Age-Related Macular Degeneration: A Systematic Review |
| title_short | Outcomes in the Treatment of Subretinal Macular Hemorrhage Secondary to Age-Related Macular Degeneration: A Systematic Review |
| title_sort | outcomes in the treatment of subretinal macular hemorrhage secondary to age related macular degeneration a systematic review |
| topic | subretinal macular hemorrhage (SRMH) age-related macular degeneration (AMD) vitreoretinal surgery recombinant tissue plasminogen activator (rt-PA) |
| url | https://www.mdpi.com/2077-0383/13/2/367 |
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