Anatomy of Hematopoiesis and Local Microenvironments in the Bone Marrow. Where to?
The shape and spatial organization -the anatomy- of a tissue profoundly influences its function. Knowledge of the anatomical relationships between parent and daughter cells is necessary to understand differentiation and how the crosstalk between the different cells in the tissue leads to physiologic...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.768439/full |
| _version_ | 1819001089790312448 |
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| author | Qingqing Wu Jizhou Zhang Daniel Lucas Daniel Lucas |
| author_facet | Qingqing Wu Jizhou Zhang Daniel Lucas Daniel Lucas |
| author_sort | Qingqing Wu |
| collection | DOAJ |
| description | The shape and spatial organization -the anatomy- of a tissue profoundly influences its function. Knowledge of the anatomical relationships between parent and daughter cells is necessary to understand differentiation and how the crosstalk between the different cells in the tissue leads to physiological maintenance and pathological perturbations. Blood cell production takes place in the bone marrow through the progressive differentiation of stem cells and progenitors. These are maintained and regulated by a heterogeneous microenvironment composed of stromal and hematopoietic cells. While hematopoiesis has been studied in extraordinary detail through functional and multiomics approaches, much less is known about the spatial organization of blood production and how local cues from the microenvironment influence this anatomy. Here, we discuss some of the studies that revealed a complex anatomy of hematopoiesis where discrete local microenvironments spatially organize and regulate specific subsets of hematopoietic stem cells and/or progenitors. We focus on the open questions in the field and discuss how new tools and technological advances are poised to transform our understanding of the anatomy of hematopoiesis. |
| first_indexed | 2024-12-20T22:43:40Z |
| format | Article |
| id | doaj.art-b3746d1441e641debf3a418a78c587cd |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-20T22:43:40Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-b3746d1441e641debf3a418a78c587cd2022-12-21T19:24:26ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-11-011210.3389/fimmu.2021.768439768439Anatomy of Hematopoiesis and Local Microenvironments in the Bone Marrow. Where to?Qingqing Wu0Jizhou Zhang1Daniel Lucas2Daniel Lucas3Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Medical Center, Cincinnati, OH, United StatesDivision of Experimental Hematology and Cancer Biology, Cincinnati Children’s Medical Center, Cincinnati, OH, United StatesDivision of Experimental Hematology and Cancer Biology, Cincinnati Children’s Medical Center, Cincinnati, OH, United StatesDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United StatesThe shape and spatial organization -the anatomy- of a tissue profoundly influences its function. Knowledge of the anatomical relationships between parent and daughter cells is necessary to understand differentiation and how the crosstalk between the different cells in the tissue leads to physiological maintenance and pathological perturbations. Blood cell production takes place in the bone marrow through the progressive differentiation of stem cells and progenitors. These are maintained and regulated by a heterogeneous microenvironment composed of stromal and hematopoietic cells. While hematopoiesis has been studied in extraordinary detail through functional and multiomics approaches, much less is known about the spatial organization of blood production and how local cues from the microenvironment influence this anatomy. Here, we discuss some of the studies that revealed a complex anatomy of hematopoiesis where discrete local microenvironments spatially organize and regulate specific subsets of hematopoietic stem cells and/or progenitors. We focus on the open questions in the field and discuss how new tools and technological advances are poised to transform our understanding of the anatomy of hematopoiesis.https://www.frontiersin.org/articles/10.3389/fimmu.2021.768439/fullanatomy of the bone marrowspatial organization of hematopoiesismicroenvironmentnichesdynamics of hematopoiesis |
| spellingShingle | Qingqing Wu Jizhou Zhang Daniel Lucas Daniel Lucas Anatomy of Hematopoiesis and Local Microenvironments in the Bone Marrow. Where to? Frontiers in Immunology anatomy of the bone marrow spatial organization of hematopoiesis microenvironment niches dynamics of hematopoiesis |
| title | Anatomy of Hematopoiesis and Local Microenvironments in the Bone Marrow. Where to? |
| title_full | Anatomy of Hematopoiesis and Local Microenvironments in the Bone Marrow. Where to? |
| title_fullStr | Anatomy of Hematopoiesis and Local Microenvironments in the Bone Marrow. Where to? |
| title_full_unstemmed | Anatomy of Hematopoiesis and Local Microenvironments in the Bone Marrow. Where to? |
| title_short | Anatomy of Hematopoiesis and Local Microenvironments in the Bone Marrow. Where to? |
| title_sort | anatomy of hematopoiesis and local microenvironments in the bone marrow where to |
| topic | anatomy of the bone marrow spatial organization of hematopoiesis microenvironment niches dynamics of hematopoiesis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.768439/full |
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