Silver/Graphene Oxide Nanostructured Coatings for Modulating the Microbial Susceptibility of Fixation Devices Used in Knee Surgery
Exploring silver-based and carbon-based nanomaterials’ excellent intrinsic antipathogenic effects represents an attractive alternative for fabricating anti-infective formulations. Using chemical synthesis protocols, stearate-conjugated silver (Ag@C<sub>18</sub>) nanoparticles and graphen...
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| Format: | Article |
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MDPI AG
2023-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/1/246 |
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| author | Sorin Constantinescu Adelina-Gabriela Niculescu Ariana Hudiță Valentina Grumezescu Dragoș Rădulescu Alexandra Cătălina Bîrcă Stefan Andrei Irimiciuc Oana Gherasim Alina Maria Holban Bianca Gălățeanu Ovidiu Cristian Oprea Anton Ficai Bogdan Ștefan Vasile Alexandru Mihai Grumezescu Alexandra Bolocan Radu Rădulescu |
| author_facet | Sorin Constantinescu Adelina-Gabriela Niculescu Ariana Hudiță Valentina Grumezescu Dragoș Rădulescu Alexandra Cătălina Bîrcă Stefan Andrei Irimiciuc Oana Gherasim Alina Maria Holban Bianca Gălățeanu Ovidiu Cristian Oprea Anton Ficai Bogdan Ștefan Vasile Alexandru Mihai Grumezescu Alexandra Bolocan Radu Rădulescu |
| author_sort | Sorin Constantinescu |
| collection | DOAJ |
| description | Exploring silver-based and carbon-based nanomaterials’ excellent intrinsic antipathogenic effects represents an attractive alternative for fabricating anti-infective formulations. Using chemical synthesis protocols, stearate-conjugated silver (Ag@C<sub>18</sub>) nanoparticles and graphene oxide nanosheets (nGOs) were herein obtained and investigated in terms of composition and microstructure. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) characterizations revealed the formation of nanomaterials with desirable physical properties, while X-ray diffraction (XRD) analyses confirmed the high purity of synthesized nanomaterials. Further, laser-processed Ag@C<sub>18</sub>-nGO coatings were developed, optimized, and evaluated in terms of biological and microbiological outcomes. The highly biocompatible Ag@C<sub>18</sub>-nGO nanostructured coatings proved suitable candidates for the local modulation of biofilm-associated periprosthetic infections. |
| first_indexed | 2024-03-08T15:05:37Z |
| format | Article |
| id | doaj.art-b375f690da214f4f8a7d7078c7164054 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-08T15:05:37Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-b375f690da214f4f8a7d7078c71640542024-01-10T14:58:44ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-12-0125124610.3390/ijms25010246Silver/Graphene Oxide Nanostructured Coatings for Modulating the Microbial Susceptibility of Fixation Devices Used in Knee SurgerySorin Constantinescu0Adelina-Gabriela Niculescu1Ariana Hudiță2Valentina Grumezescu3Dragoș Rădulescu4Alexandra Cătălina Bîrcă5Stefan Andrei Irimiciuc6Oana Gherasim7Alina Maria Holban8Bianca Gălățeanu9Ovidiu Cristian Oprea10Anton Ficai11Bogdan Ștefan Vasile12Alexandru Mihai Grumezescu13Alexandra Bolocan14Radu Rădulescu15Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Eroii Sanitari St. 8, 050474 Bucharest, RomaniaResearch Institute of the University of Bucharest—ICUB, University of Bucharest, 050657 Bucharest, RomaniaResearch Institute of the University of Bucharest—ICUB, University of Bucharest, 050657 Bucharest, RomaniaLasers Department, National Institute for Lasers, Plasma and Radiation Physics, 409 Atomistilor St., 077125 Magurele, RomaniaFaculty of Medicine, Carol Davila University of Medicine and Pharmacy, Eroii Sanitari St. 8, 050474 Bucharest, RomaniaDepartment of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, Gh. Polizu St. 1-7, 060042 Bucharest, RomaniaLasers Department, National Institute for Lasers, Plasma and Radiation Physics, 409 Atomistilor St., 077125 Magurele, RomaniaLasers Department, National Institute for Lasers, Plasma and Radiation Physics, 409 Atomistilor St., 077125 Magurele, RomaniaResearch Institute of the University of Bucharest—ICUB, University of Bucharest, 050657 Bucharest, RomaniaDepartment of Biochemistry and Molecular Biology, University of Bucharest, 050095 Bucharest, RomaniaDepartment of Inorganic Chemistry, Physical Chemistry and Electrochemistry, University Politehnica of Bucharest, 1-7 Polizu St., 011061 Bucharest, RomaniaDepartment of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, Gh. Polizu St. 1-7, 060042 Bucharest, RomaniaDepartment of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, Gh. Polizu St. 1-7, 060042 Bucharest, RomaniaResearch Institute of the University of Bucharest—ICUB, University of Bucharest, 050657 Bucharest, RomaniaFaculty of Medicine, Carol Davila University of Medicine and Pharmacy, Eroii Sanitari St. 8, 050474 Bucharest, RomaniaFaculty of Medicine, Carol Davila University of Medicine and Pharmacy, Eroii Sanitari St. 8, 050474 Bucharest, RomaniaExploring silver-based and carbon-based nanomaterials’ excellent intrinsic antipathogenic effects represents an attractive alternative for fabricating anti-infective formulations. Using chemical synthesis protocols, stearate-conjugated silver (Ag@C<sub>18</sub>) nanoparticles and graphene oxide nanosheets (nGOs) were herein obtained and investigated in terms of composition and microstructure. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) characterizations revealed the formation of nanomaterials with desirable physical properties, while X-ray diffraction (XRD) analyses confirmed the high purity of synthesized nanomaterials. Further, laser-processed Ag@C<sub>18</sub>-nGO coatings were developed, optimized, and evaluated in terms of biological and microbiological outcomes. The highly biocompatible Ag@C<sub>18</sub>-nGO nanostructured coatings proved suitable candidates for the local modulation of biofilm-associated periprosthetic infections.https://www.mdpi.com/1422-0067/25/1/246silver nanoparticlesgraphene oxide nanosheetsMAPLE coatingsbiocompatible and antimicrobial surfaces |
| spellingShingle | Sorin Constantinescu Adelina-Gabriela Niculescu Ariana Hudiță Valentina Grumezescu Dragoș Rădulescu Alexandra Cătălina Bîrcă Stefan Andrei Irimiciuc Oana Gherasim Alina Maria Holban Bianca Gălățeanu Ovidiu Cristian Oprea Anton Ficai Bogdan Ștefan Vasile Alexandru Mihai Grumezescu Alexandra Bolocan Radu Rădulescu Silver/Graphene Oxide Nanostructured Coatings for Modulating the Microbial Susceptibility of Fixation Devices Used in Knee Surgery International Journal of Molecular Sciences silver nanoparticles graphene oxide nanosheets MAPLE coatings biocompatible and antimicrobial surfaces |
| title | Silver/Graphene Oxide Nanostructured Coatings for Modulating the Microbial Susceptibility of Fixation Devices Used in Knee Surgery |
| title_full | Silver/Graphene Oxide Nanostructured Coatings for Modulating the Microbial Susceptibility of Fixation Devices Used in Knee Surgery |
| title_fullStr | Silver/Graphene Oxide Nanostructured Coatings for Modulating the Microbial Susceptibility of Fixation Devices Used in Knee Surgery |
| title_full_unstemmed | Silver/Graphene Oxide Nanostructured Coatings for Modulating the Microbial Susceptibility of Fixation Devices Used in Knee Surgery |
| title_short | Silver/Graphene Oxide Nanostructured Coatings for Modulating the Microbial Susceptibility of Fixation Devices Used in Knee Surgery |
| title_sort | silver graphene oxide nanostructured coatings for modulating the microbial susceptibility of fixation devices used in knee surgery |
| topic | silver nanoparticles graphene oxide nanosheets MAPLE coatings biocompatible and antimicrobial surfaces |
| url | https://www.mdpi.com/1422-0067/25/1/246 |
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