Effects of the local administration of antibiotics on bone formation on implant surface in animal models: A systematic review and meta-analysis
Summary: Purpose: This review aimed to evaluate the effects of the local delivery of antibiotics incorporated in implant surfaces on some quantitative parameters of bone formation. Materials and methods: An electronic search was undertaken in three databases (PubMed, Scopus, Embase) in addition to...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-11-01
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| Series: | Japanese Dental Science Review |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1882761620300156 |
| _version_ | 1818353220618027008 |
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| author | Ali Alenezi Bruno Chrcanovic |
| author_facet | Ali Alenezi Bruno Chrcanovic |
| author_sort | Ali Alenezi |
| collection | DOAJ |
| description | Summary: Purpose: This review aimed to evaluate the effects of the local delivery of antibiotics incorporated in implant surfaces on some quantitative parameters of bone formation. Materials and methods: An electronic search was undertaken in three databases (PubMed, Scopus, Embase) in addition to hand searching. The search was limited to animal experiments using endosseous implants combined with localized antibiotics release. Meta-analyses were performed for the percentages of bone volume (BV) and bone-to-implant contact (BIC). Results: Nine studies met the inclusion criteria. Several methods were identified for local delivery of antibiotics at the bone-implant interface, but the most commonly used method was by coating (incorporating the implant surface with the antibiotic agents). Different antibiotic agents were used, namely bacitracin, doxycycline, enoxacin, gentamicin, minocycline, tobramycin, and vancomycin. There was no statistically significant difference in the percentage of BIC between implants with or without localized antibiotic release (P = 0.59). The meta-analysis revealed higher BV around implants coated with antibiotics compared to control groups (without antibiotics) (P < 0.01). Conclusion: It is suggested that the local administration of antibiotics around implants did not adversely affect the percentage of direct bone contact around implants, with a tendency for a slightly better bone formation around implants when combined with local administration of antibiotics. It is a matter of debate whether these in vivo results will have the same effect in the clinical setting. However, the risk of bias of these studies may, to some extent, question the validity of these results. |
| first_indexed | 2024-12-13T19:06:04Z |
| format | Article |
| id | doaj.art-b37674b46bf8453d80d762eb2ff27290 |
| institution | Directory Open Access Journal |
| issn | 1882-7616 |
| language | English |
| last_indexed | 2024-12-13T19:06:04Z |
| publishDate | 2020-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Japanese Dental Science Review |
| spelling | doaj.art-b37674b46bf8453d80d762eb2ff272902022-12-21T23:34:32ZengElsevierJapanese Dental Science Review1882-76162020-11-01561177183Effects of the local administration of antibiotics on bone formation on implant surface in animal models: A systematic review and meta-analysisAli Alenezi0Bruno Chrcanovic1Department of Prosthodontics, College of Dentistry, Qassim University, Saudi Arabia; Corresponding author at: Department of Prosthodontics, College of Dentistry, Qassim University, P.O. Box 6700, Burydah, 51452, Saudi Arabia.Department of Prosthodontics, Faculty of Odontology, Malmö University, Malmö, SwedenSummary: Purpose: This review aimed to evaluate the effects of the local delivery of antibiotics incorporated in implant surfaces on some quantitative parameters of bone formation. Materials and methods: An electronic search was undertaken in three databases (PubMed, Scopus, Embase) in addition to hand searching. The search was limited to animal experiments using endosseous implants combined with localized antibiotics release. Meta-analyses were performed for the percentages of bone volume (BV) and bone-to-implant contact (BIC). Results: Nine studies met the inclusion criteria. Several methods were identified for local delivery of antibiotics at the bone-implant interface, but the most commonly used method was by coating (incorporating the implant surface with the antibiotic agents). Different antibiotic agents were used, namely bacitracin, doxycycline, enoxacin, gentamicin, minocycline, tobramycin, and vancomycin. There was no statistically significant difference in the percentage of BIC between implants with or without localized antibiotic release (P = 0.59). The meta-analysis revealed higher BV around implants coated with antibiotics compared to control groups (without antibiotics) (P < 0.01). Conclusion: It is suggested that the local administration of antibiotics around implants did not adversely affect the percentage of direct bone contact around implants, with a tendency for a slightly better bone formation around implants when combined with local administration of antibiotics. It is a matter of debate whether these in vivo results will have the same effect in the clinical setting. However, the risk of bias of these studies may, to some extent, question the validity of these results.http://www.sciencedirect.com/science/article/pii/S1882761620300156Dental implantsBone formationAnimal modelsDrug deliveryAntibioticsSystematic review |
| spellingShingle | Ali Alenezi Bruno Chrcanovic Effects of the local administration of antibiotics on bone formation on implant surface in animal models: A systematic review and meta-analysis Japanese Dental Science Review Dental implants Bone formation Animal models Drug delivery Antibiotics Systematic review |
| title | Effects of the local administration of antibiotics on bone formation on implant surface in animal models: A systematic review and meta-analysis |
| title_full | Effects of the local administration of antibiotics on bone formation on implant surface in animal models: A systematic review and meta-analysis |
| title_fullStr | Effects of the local administration of antibiotics on bone formation on implant surface in animal models: A systematic review and meta-analysis |
| title_full_unstemmed | Effects of the local administration of antibiotics on bone formation on implant surface in animal models: A systematic review and meta-analysis |
| title_short | Effects of the local administration of antibiotics on bone formation on implant surface in animal models: A systematic review and meta-analysis |
| title_sort | effects of the local administration of antibiotics on bone formation on implant surface in animal models a systematic review and meta analysis |
| topic | Dental implants Bone formation Animal models Drug delivery Antibiotics Systematic review |
| url | http://www.sciencedirect.com/science/article/pii/S1882761620300156 |
| work_keys_str_mv | AT alialenezi effectsofthelocaladministrationofantibioticsonboneformationonimplantsurfaceinanimalmodelsasystematicreviewandmetaanalysis AT brunochrcanovic effectsofthelocaladministrationofantibioticsonboneformationonimplantsurfaceinanimalmodelsasystematicreviewandmetaanalysis |