Drug sodium intake: Warning in cardiovascular diseases treatment
Introduction: Hypertension is a condition which represents one of the main risk factors for the development of cardiovascular diseases. High sodium intake contributes to occurrence of hypertension, increasing the volume of extracellular fluid. Therefore, World Health Organization (WHO) and other ass...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Srpsko lekarsko drustvo
2020-01-01
|
| Series: | Hospital Pharmacology |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/2334-9492/2020/2334-94922002913Q.pdf |
| _version_ | 1819159519796658176 |
|---|---|
| author | Čanji Jelena M. Todorović Nemanja B. Čović Bojana Z. Pavlović Nebojša M. Jovičić-Bata Jelena N. Goločorbin-Kon Svetlana S. Lalić-Popović Mladena N. |
| author_facet | Čanji Jelena M. Todorović Nemanja B. Čović Bojana Z. Pavlović Nebojša M. Jovičić-Bata Jelena N. Goločorbin-Kon Svetlana S. Lalić-Popović Mladena N. |
| author_sort | Čanji Jelena M. |
| collection | DOAJ |
| description | Introduction: Hypertension is a condition which represents one of the main risk factors for the development of cardiovascular diseases. High sodium intake contributes to occurrence of hypertension, increasing the volume of extracellular fluid. Therefore, World Health Organization (WHO) and other associations involved with hypertension research advise to decrease intake of sodium. Effervescent dosage forms usually contain high levels of sodium which could lead to above mentioned health issues. Aim: The aim of this study was to evaluate the levels of sodium in the effervescent dosage forms available in the Serbian drug market. Methods: Data about sodium levels, and excipients was obtained from Summary of Product Characteristics from website of Medicines and Medical Devices Agency of Serbia (ALIMS). Maximum daily doses recommended by the manufacturer and approved by ALIMS were observed. Exposure to sodium through consumption of maximum daily doses was calculated as percentages of the adequate daily intake given by Food and Nutrition Board (Institute of Medicine, National Academies, Washington D.C., USA), and also as percentage of recommended daily intake of sodium given by WHO. Results: There are five formulations with exposure to sodium through consumption of maximum daily doses higher than 100% of the adequate daily intake (2 g), all of which are effervescent tablet formulations. The highest exposure to sodium was found in effervescent tablets containing acetylsalycic acid (500 mg) as active pharmaceutical ingredient: 250.62 % for people aged 51 to 70 years; 271.50 % for people aged 70 and older. Conclusion: In effervescent dosage forms available on Serbian market, level of sodium can be very high, even up to 271.50% of adequate daily intake when maximum daily doses are consumed. Major cause for concern is for vascular patients who use effervescents for chronic therapy. This data should be considered during prescribing and dispensing this category of medicines as well as during analyzing pharmacovigilance. |
| first_indexed | 2024-12-22T16:41:51Z |
| format | Article |
| id | doaj.art-b376a91b6fdc4635bee1f1cd01013920 |
| institution | Directory Open Access Journal |
| issn | 2334-9492 2334-9492 |
| language | English |
| last_indexed | 2024-12-22T16:41:51Z |
| publishDate | 2020-01-01 |
| publisher | Srpsko lekarsko drustvo |
| record_format | Article |
| series | Hospital Pharmacology |
| spelling | doaj.art-b376a91b6fdc4635bee1f1cd010139202022-12-21T18:19:51ZengSrpsko lekarsko drustvoHospital Pharmacology2334-94922334-94922020-01-01729139222334-94922002913QDrug sodium intake: Warning in cardiovascular diseases treatmentČanji Jelena M.0Todorović Nemanja B.1Čović Bojana Z.2Pavlović Nebojša M.3Jovičić-Bata Jelena N.4Goločorbin-Kon Svetlana S.5https://orcid.org/0000-0002-2850-6375Lalić-Popović Mladena N.6https://orcid.org/0000-0001-8354-3868University of Novi Sad, Faculty of Medicine, Department of Pharmacy, SerbiaUniversity of Novi Sad, Faculty of Medicine, Department of Pharmacy, SerbiaUniversity of Novi Sad, Faculty of Medicine, Department of Pharmacy, SerbiaUniversity of Novi Sad, Faculty of Medicine, Department of Pharmacy, SerbiaUniversity of Novi Sad, Faculty of Medicine, Department of Pharmacy, SerbiaUniversity of Novi Sad, Faculty of Medicine, Department of Pharmacy, SerbiaUniversity of Novi Sad, Faculty of Medicine, Department of Pharmacy, SerbiaIntroduction: Hypertension is a condition which represents one of the main risk factors for the development of cardiovascular diseases. High sodium intake contributes to occurrence of hypertension, increasing the volume of extracellular fluid. Therefore, World Health Organization (WHO) and other associations involved with hypertension research advise to decrease intake of sodium. Effervescent dosage forms usually contain high levels of sodium which could lead to above mentioned health issues. Aim: The aim of this study was to evaluate the levels of sodium in the effervescent dosage forms available in the Serbian drug market. Methods: Data about sodium levels, and excipients was obtained from Summary of Product Characteristics from website of Medicines and Medical Devices Agency of Serbia (ALIMS). Maximum daily doses recommended by the manufacturer and approved by ALIMS were observed. Exposure to sodium through consumption of maximum daily doses was calculated as percentages of the adequate daily intake given by Food and Nutrition Board (Institute of Medicine, National Academies, Washington D.C., USA), and also as percentage of recommended daily intake of sodium given by WHO. Results: There are five formulations with exposure to sodium through consumption of maximum daily doses higher than 100% of the adequate daily intake (2 g), all of which are effervescent tablet formulations. The highest exposure to sodium was found in effervescent tablets containing acetylsalycic acid (500 mg) as active pharmaceutical ingredient: 250.62 % for people aged 51 to 70 years; 271.50 % for people aged 70 and older. Conclusion: In effervescent dosage forms available on Serbian market, level of sodium can be very high, even up to 271.50% of adequate daily intake when maximum daily doses are consumed. Major cause for concern is for vascular patients who use effervescents for chronic therapy. This data should be considered during prescribing and dispensing this category of medicines as well as during analyzing pharmacovigilance.https://scindeks-clanci.ceon.rs/data/pdf/2334-9492/2020/2334-94922002913Q.pdfsodium contenthypertensionvascular therapy |
| spellingShingle | Čanji Jelena M. Todorović Nemanja B. Čović Bojana Z. Pavlović Nebojša M. Jovičić-Bata Jelena N. Goločorbin-Kon Svetlana S. Lalić-Popović Mladena N. Drug sodium intake: Warning in cardiovascular diseases treatment Hospital Pharmacology sodium content hypertension vascular therapy |
| title | Drug sodium intake: Warning in cardiovascular diseases treatment |
| title_full | Drug sodium intake: Warning in cardiovascular diseases treatment |
| title_fullStr | Drug sodium intake: Warning in cardiovascular diseases treatment |
| title_full_unstemmed | Drug sodium intake: Warning in cardiovascular diseases treatment |
| title_short | Drug sodium intake: Warning in cardiovascular diseases treatment |
| title_sort | drug sodium intake warning in cardiovascular diseases treatment |
| topic | sodium content hypertension vascular therapy |
| url | https://scindeks-clanci.ceon.rs/data/pdf/2334-9492/2020/2334-94922002913Q.pdf |
| work_keys_str_mv | AT canjijelenam drugsodiumintakewarningincardiovasculardiseasestreatment AT todorovicnemanjab drugsodiumintakewarningincardiovasculardiseasestreatment AT covicbojanaz drugsodiumintakewarningincardiovasculardiseasestreatment AT pavlovicnebojsam drugsodiumintakewarningincardiovasculardiseasestreatment AT jovicicbatajelenan drugsodiumintakewarningincardiovasculardiseasestreatment AT golocorbinkonsvetlanas drugsodiumintakewarningincardiovasculardiseasestreatment AT lalicpopovicmladenan drugsodiumintakewarningincardiovasculardiseasestreatment |