Effects of Ginger on Spermatogenesis in Streptozotocin-induced Diabetic Rat
Background: Ginger rhizome (Zingiber officinale R., family: Zingiberaceae) is used medicinally and as a culinary spice. The medicinal use of ginger dates back to ancient China and India. Objective: Ginger and its constituents are stated to have antiemetic, antithrombotic, antihepatotoxic, anti-infla...
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| Format: | Article |
| Language: | English |
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Institue of Medicinal Plants, ACECR
2009-09-01
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| Series: | Journal of Medicinal Plants |
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| Online Access: | http://jmp.ir/article-1-339-en.html |
| _version_ | 1831587166830985216 |
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| author | M Nassiri A Khaki HR Ahmadi-Ashtiani Sh Rezazadeh H Rastgar Sh Gharachurlu |
| author_facet | M Nassiri A Khaki HR Ahmadi-Ashtiani Sh Rezazadeh H Rastgar Sh Gharachurlu |
| author_sort | M Nassiri |
| collection | DOAJ |
| description | Background: Ginger rhizome (Zingiber officinale R., family: Zingiberaceae) is used medicinally and as a culinary spice. The medicinal use of ginger dates back to ancient China and India. Objective: Ginger and its constituents are stated to have antiemetic, antithrombotic, antihepatotoxic, anti-inflammatory, stimulant, cholagogue and antioxidant.Enhanced oxidative stress and changes in antioxidant capacity are considered to play an important role in the pathogenesis of chronic diabetes mellitus. Methods: Wistar male rat (n=40) were allocated into three groups, control group (n=10) and ginger (G) group that received 100mg/kg-perday (oral), (n=10), and Diabetic group that received 55 mg/kg (IP) streptozotocin (STZ) (n=20) which was subdivided to two groups of 10 STZ group and treatment group. Treatment group received 55mg/kg (IP) STZ plus ginger 100mg/kg-perday (G), daily for, 4 weeks, respectively however, the control group just received an equal volume of distilled water daily(IP). Diabetes was induced by a single (IP) injection of streptozotocin (55 mg/kg). Animals were kept in standard condition. In 28day after inducing diabetic 5cc blood were collected for TAC, MDA and sperm parameters and testis tissues of Rat in whole groups were removed then prepared for analyzes. Results:TAC, MDA and sperm parameters significantly decreased in diabetic group.treatment groub that has received Ginger 100 mg/kg (oral) show increasing in TAC and sperm parameters (p<0.05) in comparison to experimental groups (p<0.05). Conclusion: Since in our study 100 mg/kg (oral) ginger have significantly Preventive effect on sperm parameters, so it seems that using it can be effective for treatment in Diabetic Rat. |
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| format | Article |
| id | doaj.art-b376bc68b917479ba67b92f722884207 |
| institution | Directory Open Access Journal |
| issn | 2717-204X 2717-2058 |
| language | English |
| last_indexed | 2024-12-17T21:50:07Z |
| publishDate | 2009-09-01 |
| publisher | Institue of Medicinal Plants, ACECR |
| record_format | Article |
| series | Journal of Medicinal Plants |
| spelling | doaj.art-b376bc68b917479ba67b92f7228842072022-12-21T21:31:20ZengInstitue of Medicinal Plants, ACECRJournal of Medicinal Plants2717-204X2717-20582009-09-01831118124Effects of Ginger on Spermatogenesis in Streptozotocin-induced Diabetic RatM Nassiri0A Khaki1HR Ahmadi-Ashtiani2Sh Rezazadeh3H Rastgar4Sh Gharachurlu5 Department of Veterinary Pathology, Islamic Azad University Urumia Branch Department of Veterinary Pathology (YRC), Islamic Azad University Tabriz Branch Department of Clinical Biochemistry, School of Medical Science, Tarbiat Modarres University, Tehran, Iran; Biochemistry & Nutrition Department of Zanjan Medical University Institute of Medicinal Plants, ACECR, Tehran Ministry of Health and Medical Education, Food & Drug Laboratory Research center, Department of Veterinary Pathology (YRC), Islamic Azad University Tabriz Branch Background: Ginger rhizome (Zingiber officinale R., family: Zingiberaceae) is used medicinally and as a culinary spice. The medicinal use of ginger dates back to ancient China and India. Objective: Ginger and its constituents are stated to have antiemetic, antithrombotic, antihepatotoxic, anti-inflammatory, stimulant, cholagogue and antioxidant.Enhanced oxidative stress and changes in antioxidant capacity are considered to play an important role in the pathogenesis of chronic diabetes mellitus. Methods: Wistar male rat (n=40) were allocated into three groups, control group (n=10) and ginger (G) group that received 100mg/kg-perday (oral), (n=10), and Diabetic group that received 55 mg/kg (IP) streptozotocin (STZ) (n=20) which was subdivided to two groups of 10 STZ group and treatment group. Treatment group received 55mg/kg (IP) STZ plus ginger 100mg/kg-perday (G), daily for, 4 weeks, respectively however, the control group just received an equal volume of distilled water daily(IP). Diabetes was induced by a single (IP) injection of streptozotocin (55 mg/kg). Animals were kept in standard condition. In 28day after inducing diabetic 5cc blood were collected for TAC, MDA and sperm parameters and testis tissues of Rat in whole groups were removed then prepared for analyzes. Results:TAC, MDA and sperm parameters significantly decreased in diabetic group.treatment groub that has received Ginger 100 mg/kg (oral) show increasing in TAC and sperm parameters (p<0.05) in comparison to experimental groups (p<0.05). Conclusion: Since in our study 100 mg/kg (oral) ginger have significantly Preventive effect on sperm parameters, so it seems that using it can be effective for treatment in Diabetic Rat.http://jmp.ir/article-1-339-en.htmldiabeticginger rhizomestreptozotocinspermrat |
| spellingShingle | M Nassiri A Khaki HR Ahmadi-Ashtiani Sh Rezazadeh H Rastgar Sh Gharachurlu Effects of Ginger on Spermatogenesis in Streptozotocin-induced Diabetic Rat Journal of Medicinal Plants diabetic ginger rhizome streptozotocin sperm rat |
| title | Effects of Ginger on Spermatogenesis in Streptozotocin-induced Diabetic Rat |
| title_full | Effects of Ginger on Spermatogenesis in Streptozotocin-induced Diabetic Rat |
| title_fullStr | Effects of Ginger on Spermatogenesis in Streptozotocin-induced Diabetic Rat |
| title_full_unstemmed | Effects of Ginger on Spermatogenesis in Streptozotocin-induced Diabetic Rat |
| title_short | Effects of Ginger on Spermatogenesis in Streptozotocin-induced Diabetic Rat |
| title_sort | effects of ginger on spermatogenesis in streptozotocin induced diabetic rat |
| topic | diabetic ginger rhizome streptozotocin sperm rat |
| url | http://jmp.ir/article-1-339-en.html |
| work_keys_str_mv | AT mnassiri effectsofgingeronspermatogenesisinstreptozotocininduceddiabeticrat AT akhaki effectsofgingeronspermatogenesisinstreptozotocininduceddiabeticrat AT hrahmadiashtiani effectsofgingeronspermatogenesisinstreptozotocininduceddiabeticrat AT shrezazadeh effectsofgingeronspermatogenesisinstreptozotocininduceddiabeticrat AT hrastgar effectsofgingeronspermatogenesisinstreptozotocininduceddiabeticrat AT shgharachurlu effectsofgingeronspermatogenesisinstreptozotocininduceddiabeticrat |