Ivabradine in patients with heart failure: a systematic literature review
ABSTRACTBackground: Heart failure is a chronic disease linked with significant morbidity and mortality, and uncontrolled resting heart rate is a risk factor for adverse outcomes. This systematic literature review aimed to assess the efficacy, safety, and patient-reported outcomes (PROs) of ivabradin...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Journal of Market Access & Health Policy |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/20016689.2023.2262073 |
| _version_ | 1827263583248973824 |
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| author | Zeba M. Khan Jean Baptiste Briere Elzbieta Olewinska Fatma Khrouf Mateusz Nikodem |
| author_facet | Zeba M. Khan Jean Baptiste Briere Elzbieta Olewinska Fatma Khrouf Mateusz Nikodem |
| author_sort | Zeba M. Khan |
| collection | DOAJ |
| description | ABSTRACTBackground: Heart failure is a chronic disease linked with significant morbidity and mortality, and uncontrolled resting heart rate is a risk factor for adverse outcomes. This systematic literature review aimed to assess the efficacy, safety, and patient-reported outcomes (PROs) of ivabradine in patients with heart failure (HF) with reduced ejection fraction (HFrEF) in randomized controlled trials (RCTs) and observational studies.Methods: We searched electronic databases from their inception to July 2021 to include studies that reported on efficacy, safety, or PROs of ivabradine in patients with HFrEF.Results: Of 1947 records screened, 51 RCTs and 6 observational studies were identified. Ivabradine on top of background therapy demonstrated a significant reduction in composite outcomes including hospitalization for HF or cardiovascular death. In addition, observational studies suggested that ivabradine was associated with a significant reduction in mortality. Across all studies, ivabradine use on top of background therapy was associated with greater reductions in heart rate, improved EF, and improved health-related quality of life (QoL) and comparable risk of total adverse events compared to those treated with background therapy alone.Conclusions: Ivabradine on top of background therapy is beneficial for heart rate, hospitalization risk for HF, mortality, EF, and patients’ QoL. Moreover, these benefits were achieved with no significant increase in the overall risk of total adverse events. |
| first_indexed | 2024-03-11T11:57:05Z |
| format | Article |
| id | doaj.art-b377d15c271a40acaef6de0020c11c55 |
| institution | Directory Open Access Journal |
| issn | 2001-6689 |
| language | English |
| last_indexed | 2025-03-22T03:32:28Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Market Access & Health Policy |
| spelling | doaj.art-b377d15c271a40acaef6de0020c11c552024-04-28T12:37:30ZengTaylor & Francis GroupJournal of Market Access & Health Policy2001-66892023-12-0111110.1080/20016689.2023.2262073Ivabradine in patients with heart failure: a systematic literature reviewZeba M. Khan0Jean Baptiste Briere1Elzbieta Olewinska2Fatma Khrouf3Mateusz Nikodem4Zebgene LLC, Malvern, PA, USAServier International, Suresnes, FranceHealth Economics and Outcome Research, Putnam PHMR, Cracow, PolandHealth Economics and Outcome Research, Putnam PHMR, Tunis, TunisiaHealth Economics and Outcome Research, Putnam PHMR, Cracow, PolandABSTRACTBackground: Heart failure is a chronic disease linked with significant morbidity and mortality, and uncontrolled resting heart rate is a risk factor for adverse outcomes. This systematic literature review aimed to assess the efficacy, safety, and patient-reported outcomes (PROs) of ivabradine in patients with heart failure (HF) with reduced ejection fraction (HFrEF) in randomized controlled trials (RCTs) and observational studies.Methods: We searched electronic databases from their inception to July 2021 to include studies that reported on efficacy, safety, or PROs of ivabradine in patients with HFrEF.Results: Of 1947 records screened, 51 RCTs and 6 observational studies were identified. Ivabradine on top of background therapy demonstrated a significant reduction in composite outcomes including hospitalization for HF or cardiovascular death. In addition, observational studies suggested that ivabradine was associated with a significant reduction in mortality. Across all studies, ivabradine use on top of background therapy was associated with greater reductions in heart rate, improved EF, and improved health-related quality of life (QoL) and comparable risk of total adverse events compared to those treated with background therapy alone.Conclusions: Ivabradine on top of background therapy is beneficial for heart rate, hospitalization risk for HF, mortality, EF, and patients’ QoL. Moreover, these benefits were achieved with no significant increase in the overall risk of total adverse events.https://www.tandfonline.com/doi/10.1080/20016689.2023.2262073Heart failureivabradinesystematic reviewquality of lifepatient-reported outcomes |
| spellingShingle | Zeba M. Khan Jean Baptiste Briere Elzbieta Olewinska Fatma Khrouf Mateusz Nikodem Ivabradine in patients with heart failure: a systematic literature review Journal of Market Access & Health Policy Heart failure ivabradine systematic review quality of life patient-reported outcomes |
| title | Ivabradine in patients with heart failure: a systematic literature review |
| title_full | Ivabradine in patients with heart failure: a systematic literature review |
| title_fullStr | Ivabradine in patients with heart failure: a systematic literature review |
| title_full_unstemmed | Ivabradine in patients with heart failure: a systematic literature review |
| title_short | Ivabradine in patients with heart failure: a systematic literature review |
| title_sort | ivabradine in patients with heart failure a systematic literature review |
| topic | Heart failure ivabradine systematic review quality of life patient-reported outcomes |
| url | https://www.tandfonline.com/doi/10.1080/20016689.2023.2262073 |
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