Composite quantitative knee structure metrics predict the development of accelerated knee osteoarthritis: data from the osteoarthritis initiative
Abstract Background We aimed to determine if composite structural measures of knee osteoarthritis (KOA) progression on magnetic resonance (MR) imaging can predict the radiographic onset of accelerated knee osteoarthritis. Methods We used data from a nested case-control study among participants from...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
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BMC
2020-05-01
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| Series: | BMC Musculoskeletal Disorders |
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| Online Access: | http://link.springer.com/article/10.1186/s12891-020-03338-7 |
| _version_ | 1828492659920994304 |
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| author | Matthew S. Harkey Julie E. Davis Lori Lyn Price Robert J. Ward James W. MacKay Charles B. Eaton Grace H. Lo Mary F. Barbe Ming Zhang Jincheng Pang Alina C. Stout Bing Lu Timothy E. McAlindon Jeffrey B. Driban |
| author_facet | Matthew S. Harkey Julie E. Davis Lori Lyn Price Robert J. Ward James W. MacKay Charles B. Eaton Grace H. Lo Mary F. Barbe Ming Zhang Jincheng Pang Alina C. Stout Bing Lu Timothy E. McAlindon Jeffrey B. Driban |
| author_sort | Matthew S. Harkey |
| collection | DOAJ |
| description | Abstract Background We aimed to determine if composite structural measures of knee osteoarthritis (KOA) progression on magnetic resonance (MR) imaging can predict the radiographic onset of accelerated knee osteoarthritis. Methods We used data from a nested case-control study among participants from the Osteoarthritis Initiative without radiographic KOA at baseline. Participants were separated into three groups based on radiographic disease progression over 4 years: 1) accelerated (Kellgren-Lawrence grades [KL] 0/1 to 3/4), 2) typical (increase in KL, excluding accelerated osteoarthritis), or 3) no KOA (no change in KL). We assessed tibiofemoral cartilage damage (four regions: medial/lateral tibia/femur), bone marrow lesion (BML) volume (four regions: medial/lateral tibia/femur), and whole knee effusion-synovitis volume on 3 T MR images with semi-automated programs. We calculated two MR-based composite scores. Cumulative damage was the sum of standardized cartilage damage. Disease activity was the sum of standardized volumes of effusion-synovitis and BMLs. We focused on annual images from 2 years before to 2 years after radiographic onset (or a matched time for those without knee osteoarthritis). To determine between group differences in the composite metrics at all time points, we used generalized linear mixed models with group (3 levels) and time (up to 5 levels). For our prognostic analysis, we used multinomial logistic regression models to determine if one-year worsening in each composite metric change associated with future accelerated knee osteoarthritis (odds ratios [OR] based on units of 1 standard deviation of change). Results Prior to disease onset, the accelerated KOA group had greater average disease activity compared to the typical and no KOA groups and this persisted up to 2 years after disease onset. During a pre-radiographic disease period, the odds of developing accelerated KOA were greater in people with worsening disease activity [versus typical KOA OR (95% confidence interval [CI]): 1.58 (1.08 to 2.33); versus no KOA: 2.39 (1.55 to 3.71)] or cumulative damage [versus typical KOA: 1.69 (1.14 to 2.51); versus no KOA: 2.11 (1.41 to 3.16)]. Conclusions MR-based disease activity and cumulative damage metrics may be prognostic markers to help identify people at risk for accelerated onset and progression of knee osteoarthritis. |
| first_indexed | 2024-12-11T11:24:30Z |
| format | Article |
| id | doaj.art-b37c5bfb3d934bff9d15a2d7e5de36c2 |
| institution | Directory Open Access Journal |
| issn | 1471-2474 |
| language | English |
| last_indexed | 2024-12-11T11:24:30Z |
| publishDate | 2020-05-01 |
| publisher | BMC |
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| series | BMC Musculoskeletal Disorders |
| spelling | doaj.art-b37c5bfb3d934bff9d15a2d7e5de36c22022-12-22T01:09:03ZengBMCBMC Musculoskeletal Disorders1471-24742020-05-0121111010.1186/s12891-020-03338-7Composite quantitative knee structure metrics predict the development of accelerated knee osteoarthritis: data from the osteoarthritis initiativeMatthew S. Harkey0Julie E. Davis1Lori Lyn Price2Robert J. Ward3James W. MacKay4Charles B. Eaton5Grace H. Lo6Mary F. Barbe7Ming Zhang8Jincheng Pang9Alina C. Stout10Bing Lu11Timothy E. McAlindon12Jeffrey B. Driban13Division of Rheumatology, Allergy, & Immunology, Tufts Medical CenterDepartment of Global Health in the Milken Institute of Public Health, George Washington UniversityThe Institute for Clinical Research and Health Policy Studies, Tufts Medical CenterDepartment of Radiology, Tufts Medical CenterNorwich Medical School, University of East AngliaCenter for Primary Care and Prevention, Alpert Medical School of Brown UniversityMedical Care Line and Research Care Line, Houston Health Services Research and Development Center of Excellence Michael E. DeBakey VAMCDepartment of Anatomy and Cell Biology, Temple University School of MedicineDivision of Rheumatology, Allergy, & Immunology, Tufts Medical CenterPfizer Inc.Public Health Institute, Northeastern UniversityDivision of Rheumatology, Immunology & Allergy, Brigham & Women’s Hospital and Harvard Medical SchoolDivision of Rheumatology, Allergy, & Immunology, Tufts Medical CenterDivision of Rheumatology, Allergy, & Immunology, Tufts Medical CenterAbstract Background We aimed to determine if composite structural measures of knee osteoarthritis (KOA) progression on magnetic resonance (MR) imaging can predict the radiographic onset of accelerated knee osteoarthritis. Methods We used data from a nested case-control study among participants from the Osteoarthritis Initiative without radiographic KOA at baseline. Participants were separated into three groups based on radiographic disease progression over 4 years: 1) accelerated (Kellgren-Lawrence grades [KL] 0/1 to 3/4), 2) typical (increase in KL, excluding accelerated osteoarthritis), or 3) no KOA (no change in KL). We assessed tibiofemoral cartilage damage (four regions: medial/lateral tibia/femur), bone marrow lesion (BML) volume (four regions: medial/lateral tibia/femur), and whole knee effusion-synovitis volume on 3 T MR images with semi-automated programs. We calculated two MR-based composite scores. Cumulative damage was the sum of standardized cartilage damage. Disease activity was the sum of standardized volumes of effusion-synovitis and BMLs. We focused on annual images from 2 years before to 2 years after radiographic onset (or a matched time for those without knee osteoarthritis). To determine between group differences in the composite metrics at all time points, we used generalized linear mixed models with group (3 levels) and time (up to 5 levels). For our prognostic analysis, we used multinomial logistic regression models to determine if one-year worsening in each composite metric change associated with future accelerated knee osteoarthritis (odds ratios [OR] based on units of 1 standard deviation of change). Results Prior to disease onset, the accelerated KOA group had greater average disease activity compared to the typical and no KOA groups and this persisted up to 2 years after disease onset. During a pre-radiographic disease period, the odds of developing accelerated KOA were greater in people with worsening disease activity [versus typical KOA OR (95% confidence interval [CI]): 1.58 (1.08 to 2.33); versus no KOA: 2.39 (1.55 to 3.71)] or cumulative damage [versus typical KOA: 1.69 (1.14 to 2.51); versus no KOA: 2.11 (1.41 to 3.16)]. Conclusions MR-based disease activity and cumulative damage metrics may be prognostic markers to help identify people at risk for accelerated onset and progression of knee osteoarthritis.http://link.springer.com/article/10.1186/s12891-020-03338-7Magnetic resonance imagingCartilageBone marrow lesionsEffusionSynovitis |
| spellingShingle | Matthew S. Harkey Julie E. Davis Lori Lyn Price Robert J. Ward James W. MacKay Charles B. Eaton Grace H. Lo Mary F. Barbe Ming Zhang Jincheng Pang Alina C. Stout Bing Lu Timothy E. McAlindon Jeffrey B. Driban Composite quantitative knee structure metrics predict the development of accelerated knee osteoarthritis: data from the osteoarthritis initiative BMC Musculoskeletal Disorders Magnetic resonance imaging Cartilage Bone marrow lesions Effusion Synovitis |
| title | Composite quantitative knee structure metrics predict the development of accelerated knee osteoarthritis: data from the osteoarthritis initiative |
| title_full | Composite quantitative knee structure metrics predict the development of accelerated knee osteoarthritis: data from the osteoarthritis initiative |
| title_fullStr | Composite quantitative knee structure metrics predict the development of accelerated knee osteoarthritis: data from the osteoarthritis initiative |
| title_full_unstemmed | Composite quantitative knee structure metrics predict the development of accelerated knee osteoarthritis: data from the osteoarthritis initiative |
| title_short | Composite quantitative knee structure metrics predict the development of accelerated knee osteoarthritis: data from the osteoarthritis initiative |
| title_sort | composite quantitative knee structure metrics predict the development of accelerated knee osteoarthritis data from the osteoarthritis initiative |
| topic | Magnetic resonance imaging Cartilage Bone marrow lesions Effusion Synovitis |
| url | http://link.springer.com/article/10.1186/s12891-020-03338-7 |
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