Exploring the Regulatory Role of ncRNA in NAFLD: A Particular Focus on PPARs
Liver diseases are responsible for global mortality and morbidity and are a significant cause of death worldwide. Consequently, the advancement of new liver disease targets is of great interest. Non-coding RNA (ncRNA), such as microRNA (miRNA) and long ncRNA (lncRNA), has been proven to play a signi...
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MDPI AG
2022-12-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/24/3959 |
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| author | Anirban Goutam Mukherjee Uddesh Ramesh Wanjari Abilash Valsala Gopalakrishnan Ramkumar Katturajan Sandra Kannampuzha Reshma Murali Arunraj Namachivayam Raja Ganesan Kaviyarasi Renu Abhijit Dey Balachandar Vellingiri Sabina Evan Prince |
| author_facet | Anirban Goutam Mukherjee Uddesh Ramesh Wanjari Abilash Valsala Gopalakrishnan Ramkumar Katturajan Sandra Kannampuzha Reshma Murali Arunraj Namachivayam Raja Ganesan Kaviyarasi Renu Abhijit Dey Balachandar Vellingiri Sabina Evan Prince |
| author_sort | Anirban Goutam Mukherjee |
| collection | DOAJ |
| description | Liver diseases are responsible for global mortality and morbidity and are a significant cause of death worldwide. Consequently, the advancement of new liver disease targets is of great interest. Non-coding RNA (ncRNA), such as microRNA (miRNA) and long ncRNA (lncRNA), has been proven to play a significant role in the pathogenesis of virtually all acute and chronic liver disorders. Recent studies demonstrated the medical applications of miRNA in various phases of hepatic pathology. PPARs play a major role in regulating many signaling pathways involved in various metabolic disorders. Non-alcoholic fatty liver disease (NAFLD) is the most prevalent form of chronic liver disease in the world, encompassing a spectrum spanning from mild steatosis to severe non-alcoholic steatohepatitis (NASH). PPARs were found to be one of the major regulators in the progression of NAFLD. There is no recognized treatment for NAFLD, even though numerous clinical trials are now underway. NAFLD is a major risk factor for developing hepatocellular carcinoma (HCC), and its frequency increases as obesity and diabetes become more prevalent. Reprogramming anti-diabetic and anti-obesity drugs is an effective therapy option for NAFLD and NASH. Several studies have also focused on the role of ncRNAs in the pathophysiology of NAFLD. The regulatory effects of these ncRNAs make them a primary target for treatments and as early biomarkers. In this study, the main focus will be to understand the regulation of PPARs through ncRNAs and their role in NAFLD. |
| first_indexed | 2024-03-09T17:13:37Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T17:13:37Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-b3805316a05e479c9c60df318d44de9a2023-11-24T13:53:27ZengMDPI AGCells2073-44092022-12-011124395910.3390/cells11243959Exploring the Regulatory Role of ncRNA in NAFLD: A Particular Focus on PPARsAnirban Goutam Mukherjee0Uddesh Ramesh Wanjari1Abilash Valsala Gopalakrishnan2Ramkumar Katturajan3Sandra Kannampuzha4Reshma Murali5Arunraj Namachivayam6Raja Ganesan7Kaviyarasi Renu8Abhijit Dey9Balachandar Vellingiri10Sabina Evan Prince11Department of Biomedical Sciences, School of Biosciences and Technology, Vellore Institute of Technology (VIT), Vellore 632014, Tamil Nadu, IndiaDepartment of Biomedical Sciences, School of Biosciences and Technology, Vellore Institute of Technology (VIT), Vellore 632014, Tamil Nadu, IndiaDepartment of Biomedical Sciences, School of Biosciences and Technology, Vellore Institute of Technology (VIT), Vellore 632014, Tamil Nadu, IndiaDepartment of Biomedical Sciences, School of Biosciences and Technology, Vellore Institute of Technology (VIT), Vellore 632014, Tamil Nadu, IndiaDepartment of Biomedical Sciences, School of Biosciences and Technology, Vellore Institute of Technology (VIT), Vellore 632014, Tamil Nadu, IndiaDepartment of Biomedical Sciences, School of Biosciences and Technology, Vellore Institute of Technology (VIT), Vellore 632014, Tamil Nadu, IndiaDepartment of Biomedical Sciences, School of Biosciences and Technology, Vellore Institute of Technology (VIT), Vellore 632014, Tamil Nadu, IndiaInstitute for Liver and Digestive Diseases, Hallym University, Chuncheon 24252, Republic of KoreaCentre of Molecular Medicine and Diagnostics (COMManD), Department of Biochemistry, Saveetha Dental College & Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 600077, Tamil Nadu, IndiaDepartment of Life Sciences, Presidency University, Kolkata 700073, West Bengal, IndiaStem Cell and Regenerative Medicine/Translational Research, Department of Zoology, School of Basic Sciences, Central University of Punjab (CUPB), Bathinda 151401, Punjab, IndiaDepartment of Biomedical Sciences, School of Biosciences and Technology, Vellore Institute of Technology (VIT), Vellore 632014, Tamil Nadu, IndiaLiver diseases are responsible for global mortality and morbidity and are a significant cause of death worldwide. Consequently, the advancement of new liver disease targets is of great interest. Non-coding RNA (ncRNA), such as microRNA (miRNA) and long ncRNA (lncRNA), has been proven to play a significant role in the pathogenesis of virtually all acute and chronic liver disorders. Recent studies demonstrated the medical applications of miRNA in various phases of hepatic pathology. PPARs play a major role in regulating many signaling pathways involved in various metabolic disorders. Non-alcoholic fatty liver disease (NAFLD) is the most prevalent form of chronic liver disease in the world, encompassing a spectrum spanning from mild steatosis to severe non-alcoholic steatohepatitis (NASH). PPARs were found to be one of the major regulators in the progression of NAFLD. There is no recognized treatment for NAFLD, even though numerous clinical trials are now underway. NAFLD is a major risk factor for developing hepatocellular carcinoma (HCC), and its frequency increases as obesity and diabetes become more prevalent. Reprogramming anti-diabetic and anti-obesity drugs is an effective therapy option for NAFLD and NASH. Several studies have also focused on the role of ncRNAs in the pathophysiology of NAFLD. The regulatory effects of these ncRNAs make them a primary target for treatments and as early biomarkers. In this study, the main focus will be to understand the regulation of PPARs through ncRNAs and their role in NAFLD.https://www.mdpi.com/2073-4409/11/24/3959PPARsNAFLDncRNAliverNASH |
| spellingShingle | Anirban Goutam Mukherjee Uddesh Ramesh Wanjari Abilash Valsala Gopalakrishnan Ramkumar Katturajan Sandra Kannampuzha Reshma Murali Arunraj Namachivayam Raja Ganesan Kaviyarasi Renu Abhijit Dey Balachandar Vellingiri Sabina Evan Prince Exploring the Regulatory Role of ncRNA in NAFLD: A Particular Focus on PPARs Cells PPARs NAFLD ncRNA liver NASH |
| title | Exploring the Regulatory Role of ncRNA in NAFLD: A Particular Focus on PPARs |
| title_full | Exploring the Regulatory Role of ncRNA in NAFLD: A Particular Focus on PPARs |
| title_fullStr | Exploring the Regulatory Role of ncRNA in NAFLD: A Particular Focus on PPARs |
| title_full_unstemmed | Exploring the Regulatory Role of ncRNA in NAFLD: A Particular Focus on PPARs |
| title_short | Exploring the Regulatory Role of ncRNA in NAFLD: A Particular Focus on PPARs |
| title_sort | exploring the regulatory role of ncrna in nafld a particular focus on ppars |
| topic | PPARs NAFLD ncRNA liver NASH |
| url | https://www.mdpi.com/2073-4409/11/24/3959 |
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