Chronic Stress-Induced Depression and Anxiety Priming Modulated by Gut-Brain-Axis Immunity
Chronic stress manifests as depressive- and anxiety-like behavior while recurrent stress elicits disproportionate behavioral impairments linked to stress-induced immunological priming. The gut-brain-microbiota-axis is a promising therapeutic target for stress-induced behavioral impairments as it sim...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.670500/full |
| _version_ | 1818589063603552256 |
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| author | Susan Westfall Francesca Caracci Molly Estill Tal Frolinger Li Shen Giulio M. Pasinetti Giulio M. Pasinetti |
| author_facet | Susan Westfall Francesca Caracci Molly Estill Tal Frolinger Li Shen Giulio M. Pasinetti Giulio M. Pasinetti |
| author_sort | Susan Westfall |
| collection | DOAJ |
| description | Chronic stress manifests as depressive- and anxiety-like behavior while recurrent stress elicits disproportionate behavioral impairments linked to stress-induced immunological priming. The gut-brain-microbiota-axis is a promising therapeutic target for stress-induced behavioral impairments as it simultaneously modulates peripheral and brain immunological landscapes. In this study, a combination of probiotics and prebiotics, known as a synbiotic, promoted behavioral resilience to chronic and recurrent stress by normalizing gut microbiota populations and promoting regulatory T cell (Treg) expansion through modulation of ileal innate lymphoid cell (ILC)3 activity, an impact reflecting behavioral responses better than limbic brain region neuroinflammation. Supporting this conclusion, a multivariate machine learning model correlatively predicted a cross-tissue immunological signature of stress-induced behavioral impairment where the ileal Treg/T helper17 cell ratio associated to hippocampal chemotactic chemokine and prefrontal cortex IL-1β production in the context of stress-induced behavioral deficits. In conclusion, stress-induced behavioral impairments depend on the gut-brain-microbiota-axis and through ileal immune regulation, synbiotics attenuate the associated depressive- and anxiety-like behavior. |
| first_indexed | 2024-12-16T09:34:42Z |
| format | Article |
| id | doaj.art-b381a3a05d3641478a5f87fff0d38d19 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-16T09:34:42Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-b381a3a05d3641478a5f87fff0d38d192022-12-21T22:36:26ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-06-011210.3389/fimmu.2021.670500670500Chronic Stress-Induced Depression and Anxiety Priming Modulated by Gut-Brain-Axis ImmunitySusan Westfall0Francesca Caracci1Molly Estill2Tal Frolinger3Li Shen4Giulio M. Pasinetti5Giulio M. Pasinetti6Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesDepartment of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesDepartment of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesGeriatric Research, Education and Clinical Center, James J. Peters Veterans Affairs Medical Center, Bronx, NY, United StatesChronic stress manifests as depressive- and anxiety-like behavior while recurrent stress elicits disproportionate behavioral impairments linked to stress-induced immunological priming. The gut-brain-microbiota-axis is a promising therapeutic target for stress-induced behavioral impairments as it simultaneously modulates peripheral and brain immunological landscapes. In this study, a combination of probiotics and prebiotics, known as a synbiotic, promoted behavioral resilience to chronic and recurrent stress by normalizing gut microbiota populations and promoting regulatory T cell (Treg) expansion through modulation of ileal innate lymphoid cell (ILC)3 activity, an impact reflecting behavioral responses better than limbic brain region neuroinflammation. Supporting this conclusion, a multivariate machine learning model correlatively predicted a cross-tissue immunological signature of stress-induced behavioral impairment where the ileal Treg/T helper17 cell ratio associated to hippocampal chemotactic chemokine and prefrontal cortex IL-1β production in the context of stress-induced behavioral deficits. In conclusion, stress-induced behavioral impairments depend on the gut-brain-microbiota-axis and through ileal immune regulation, synbiotics attenuate the associated depressive- and anxiety-like behavior.https://www.frontiersin.org/articles/10.3389/fimmu.2021.670500/fullprobioticnutraceuticalinnate lymphocyte cellspsychiatrymicrobiota |
| spellingShingle | Susan Westfall Francesca Caracci Molly Estill Tal Frolinger Li Shen Giulio M. Pasinetti Giulio M. Pasinetti Chronic Stress-Induced Depression and Anxiety Priming Modulated by Gut-Brain-Axis Immunity Frontiers in Immunology probiotic nutraceutical innate lymphocyte cells psychiatry microbiota |
| title | Chronic Stress-Induced Depression and Anxiety Priming Modulated by Gut-Brain-Axis Immunity |
| title_full | Chronic Stress-Induced Depression and Anxiety Priming Modulated by Gut-Brain-Axis Immunity |
| title_fullStr | Chronic Stress-Induced Depression and Anxiety Priming Modulated by Gut-Brain-Axis Immunity |
| title_full_unstemmed | Chronic Stress-Induced Depression and Anxiety Priming Modulated by Gut-Brain-Axis Immunity |
| title_short | Chronic Stress-Induced Depression and Anxiety Priming Modulated by Gut-Brain-Axis Immunity |
| title_sort | chronic stress induced depression and anxiety priming modulated by gut brain axis immunity |
| topic | probiotic nutraceutical innate lymphocyte cells psychiatry microbiota |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.670500/full |
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