Effects of radioiodine therapy on pregnancy and its complication in differentiated thyroid cancer comparing with their healthy sisters
Background: Differentiated thyroid cancer (DTC) frequently occurs in women at fertility age. One of the cornerstones in treating this malignancy is Radioactive Iodine (RAI) therapy following thyroid resection. In this study, we evaluated the effect of RAI therapy on the fertility rate and pregnancy...
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| Format: | Article |
| Language: | fas |
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Tehran University of Medical Sciences
2019-10-01
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| Series: | Tehran University Medical Journal |
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| Online Access: | http://tumj.tums.ac.ir/article-1-10006-en.html |
| _version_ | 1818522993372954624 |
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| author | Atiyeh Vatanchi Narjess Ayati Susan Shafiei Farzane Ashourzade Leila Purali Seyed Rasoul Zakavi |
| author_facet | Atiyeh Vatanchi Narjess Ayati Susan Shafiei Farzane Ashourzade Leila Purali Seyed Rasoul Zakavi |
| author_sort | Atiyeh Vatanchi |
| collection | DOAJ |
| description | Background: Differentiated thyroid cancer (DTC) frequently occurs in women at fertility age. One of the cornerstones in treating this malignancy is Radioactive Iodine (RAI) therapy following thyroid resection. In this study, we evaluated the effect of RAI therapy on the fertility rate and pregnancy complications.
Methods: This is a retrospective study on 41 patients with differentiated thyroid cancer, with at least one experience of pregnancy after standard treatment (thyroid resection followed by radioiodine therapy). All patients have been signed a written consent form in initial admission to our department. Furthermore, we asked our patients to fill in a questionnaire about their thyroid cancer and its treatment as well as pregnancy and its complication. As a control group with no different mean age, the same checklist has also been filled in for the patient’s healthy sister too, just related to gravidity and its complications. The complications of pregnancy were registered in these patients and compared with the control group consisted of their healthy sisters. Also, the association of abortion rate with other underlying factors has been assessed. All data has been included in SPSS software, version 22 (IBM SPSS, Armonk, NY, USA) and analyzed using logistic regression. This study conducted at the Nuclear Medicine Department of Ghaem Hospital in Mashhad, from May 2017 to February 2018 with the support of Mashhad University of Medical Sciences, Iran.
Results: No significant difference was noted in the mean age between case (differentiated thyroid cancer) and control groups (P=0.9). The two groups were also statistically similar in terms of pregnancy frequency (P=0.05) and number of alive children (P=0.8). Abortion seems to be the only item in DTC patients which was more than healthy sisters (0.2 versus 0.7) (P=0.003). However, this statistical difference showed no direct relationship with radioiodine treatment (RIT). As in DTC patients before and after RIT, no significant difference has been detected in DTC patients before and after RIT (P=0.48). Birth weight was not statistically different in DTC patients before and after RIT (P=0.66) and between DTC patients and their healthy sisters (P=0.2).
Conclusion: Radioiodine therapy for differentiated thyroid carcinoma has no considerable negative impact on pregnancy, whether on fertility rate or on gravity complications. |
| first_indexed | 2024-12-11T05:39:53Z |
| format | Article |
| id | doaj.art-b381e49938854c30979fb738e51e669f |
| institution | Directory Open Access Journal |
| issn | 1683-1764 1735-7322 |
| language | fas |
| last_indexed | 2024-12-11T05:39:53Z |
| publishDate | 2019-10-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Tehran University Medical Journal |
| spelling | doaj.art-b381e49938854c30979fb738e51e669f2022-12-22T01:19:10ZfasTehran University of Medical SciencesTehran University Medical Journal1683-17641735-73222019-10-01777445452Effects of radioiodine therapy on pregnancy and its complication in differentiated thyroid cancer comparing with their healthy sistersAtiyeh Vatanchi0Narjess Ayati1Susan Shafiei2Farzane Ashourzade3Leila Purali4Seyed Rasoul Zakavi5 Department of Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Department of Nuclear Medicine, Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Department of Nuclear Medicine, Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. General Practitioner, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Department of Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Department of Nuclear Medicine, Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Background: Differentiated thyroid cancer (DTC) frequently occurs in women at fertility age. One of the cornerstones in treating this malignancy is Radioactive Iodine (RAI) therapy following thyroid resection. In this study, we evaluated the effect of RAI therapy on the fertility rate and pregnancy complications. Methods: This is a retrospective study on 41 patients with differentiated thyroid cancer, with at least one experience of pregnancy after standard treatment (thyroid resection followed by radioiodine therapy). All patients have been signed a written consent form in initial admission to our department. Furthermore, we asked our patients to fill in a questionnaire about their thyroid cancer and its treatment as well as pregnancy and its complication. As a control group with no different mean age, the same checklist has also been filled in for the patient’s healthy sister too, just related to gravidity and its complications. The complications of pregnancy were registered in these patients and compared with the control group consisted of their healthy sisters. Also, the association of abortion rate with other underlying factors has been assessed. All data has been included in SPSS software, version 22 (IBM SPSS, Armonk, NY, USA) and analyzed using logistic regression. This study conducted at the Nuclear Medicine Department of Ghaem Hospital in Mashhad, from May 2017 to February 2018 with the support of Mashhad University of Medical Sciences, Iran. Results: No significant difference was noted in the mean age between case (differentiated thyroid cancer) and control groups (P=0.9). The two groups were also statistically similar in terms of pregnancy frequency (P=0.05) and number of alive children (P=0.8). Abortion seems to be the only item in DTC patients which was more than healthy sisters (0.2 versus 0.7) (P=0.003). However, this statistical difference showed no direct relationship with radioiodine treatment (RIT). As in DTC patients before and after RIT, no significant difference has been detected in DTC patients before and after RIT (P=0.48). Birth weight was not statistically different in DTC patients before and after RIT (P=0.66) and between DTC patients and their healthy sisters (P=0.2). Conclusion: Radioiodine therapy for differentiated thyroid carcinoma has no considerable negative impact on pregnancy, whether on fertility rate or on gravity complications.http://tumj.tums.ac.ir/article-1-10006-en.htmlabortioniodinepregnancyretrospective studiesthyroid neoplasms |
| spellingShingle | Atiyeh Vatanchi Narjess Ayati Susan Shafiei Farzane Ashourzade Leila Purali Seyed Rasoul Zakavi Effects of radioiodine therapy on pregnancy and its complication in differentiated thyroid cancer comparing with their healthy sisters Tehran University Medical Journal abortion iodine pregnancy retrospective studies thyroid neoplasms |
| title | Effects of radioiodine therapy on pregnancy and its complication in differentiated thyroid cancer comparing with their healthy sisters |
| title_full | Effects of radioiodine therapy on pregnancy and its complication in differentiated thyroid cancer comparing with their healthy sisters |
| title_fullStr | Effects of radioiodine therapy on pregnancy and its complication in differentiated thyroid cancer comparing with their healthy sisters |
| title_full_unstemmed | Effects of radioiodine therapy on pregnancy and its complication in differentiated thyroid cancer comparing with their healthy sisters |
| title_short | Effects of radioiodine therapy on pregnancy and its complication in differentiated thyroid cancer comparing with their healthy sisters |
| title_sort | effects of radioiodine therapy on pregnancy and its complication in differentiated thyroid cancer comparing with their healthy sisters |
| topic | abortion iodine pregnancy retrospective studies thyroid neoplasms |
| url | http://tumj.tums.ac.ir/article-1-10006-en.html |
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