Unravelling the Sequential Interplay of Mutational Mechanisms during Clonal Evolution in Relapsed Pediatric Acute Lymphoblastic Leukemia
Pediatric acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy and is characterized by clonal heterogeneity. Genomic mutations can increase proliferative potential of leukemic cells and cause treatment resistance. However, mechanisms driving mutagenesis and clonal diversificati...
Main Authors: | Željko Antić, Stefan H. Lelieveld, Cédric G. van der Ham, Edwin Sonneveld, Peter M. Hoogerbrugge, Roland P. Kuiper |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-02-01
|
Series: | Genes |
Subjects: | |
Online Access: | https://www.mdpi.com/2073-4425/12/2/214 |
Similar Items
-
NSD2 E1099K drives relapse in pediatric acute lymphoblastic leukemia by disrupting 3D chromatin organization
by: Sonali Narang, et al.
Published: (2023-04-01) -
Effects of PRPS1 I72 mutations on drug resistance in acute lymphoblastic leukemia and its mechanisms
by: CUI Zhiyan, et al.
Published: (2023-08-01) -
Relapses Children’s Acute Lymphoblastic Leukemia, Single Center Experience
by: Weronika Stolpa, et al.
Published: (2022-11-01) -
Detection of Thiopurine S-Methyltransferase (TPMT) Polymorphisms TPMT*3A, TPMT*3B and TPMT*3C in Children with Acute Lymphoblastic Leukemia
by: Nawar S. Mohammed, et al.
Published: (2018-12-01) -
Other (Non-CNS/Testicular) Extramedullary Localizations of Childhood Relapsed Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma—A Report from the ALL-REZ Study Group
by: Andrej Lissat, et al.
Published: (2021-11-01)