The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome

The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome

Abstract The current model is that the influenza virus polymerase (FluPol) binds either to host RNA polymerase II (RNAP II) or to the acidic nuclear phosphoprotein 32 (ANP32), which drives its conformation and activity towards transcription or replication of the viral genome, respectively. Here, we...

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Bibliographic Details
Main Authors: Tim Krischuns, Benoît Arragain, Catherine Isel, Sylvain Paisant, Matthias Budt, Thorsten Wolff, Stephen Cusack, Nadia Naffakh
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-45205-2

Internet

https://doi.org/10.1038/s41467-024-45205-2

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