The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome

The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome

Abstract The current model is that the influenza virus polymerase (FluPol) binds either to host RNA polymerase II (RNAP II) or to the acidic nuclear phosphoprotein 32 (ANP32), which drives its conformation and activity towards transcription or replication of the viral genome, respectively. Here, we...

Full description

Bibliographic Details
Main Authors:	Tim Krischuns, Benoît Arragain, Catherine Isel, Sylvain Paisant, Matthias Budt, Thorsten Wolff, Stephen Cusack, Nadia Naffakh
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-02-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-024-45205-2

Similar Items

Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD.
by: Tim Krischuns, et al.
Published: (2022-05-01)

Influenza virus polymerase subunits co-evolve to ensure proper levels of dimerization of the heterotrimer.
by: Kuang-Yu Chen, et al.
Published: (2019-10-01)

Structural and functional analysis of the minimal orthomyxovirus-like polymerase of Tilapia Lake Virus from the highly diverged Amnoonviridae family
by: Benoit Arragain, et al.
Published: (2023-12-01)

Experimental Approaches to Study Genome Packaging of Influenza A Viruses
by: Catherine Isel, et al.
Published: (2016-08-01)

Highly pathogenic H5N1 influenza A virus strains provoke heterogeneous IFN-α/β responses that distinctively affect viral propagation in human cells.
by: Markus Matthaei, et al.
Published: (2013-01-01)

Structures of active Hantaan virus polymerase uncover the mechanisms of Hantaviridae genome replication
by: Quentin Durieux Trouilleton, et al.
Published: (2023-05-01)

The ubiquitination landscape of the influenza A virus polymerase
by: Franziska Günl, et al.
Published: (2023-02-01)

Bunyaviridae RNA polymerases (L-protein) have an N-terminal, influenza-like endonuclease domain, essential for viral cap-dependent transcription.
by: Juan Reguera, et al.
Published: (2010-09-01)

Time-Resolved Visualisation of Nearly-Native Influenza A Virus Progeny Ribonucleoproteins and Their Individual Components in Live Infected Cells.
by: Sergiy Avilov, et al.
Published: (2016-01-01)

A polarized cell system amenable to subcellular resolution imaging of influenza virus infection
by: Jean-Baptiste Brault, et al.
Published: (2024-01-01)

The N-terminal region of influenza virus polymerase PB1 adjacent to the PA binding site is involved in replication but not transcription of the viral genome
by: Nguyen Trong Binh, et al.
Published: (2013-12-01)

Role of the influenza virus heterotrimeric RNA polymerase complex in the initiation of replication.
by: Deng, T, et al.
Published: (2006)

The RNA polymerase of influenza a virus: mechanisms of viral transcription and replication.
by: Fodor, E
Published: (2013)

Roles for DNA polymerase δ in initiating and terminating leading strand DNA replication
by: Zhi-Xiong Zhou, et al.
Published: (2019-09-01)

Structural characterization of the oligomerization of full-length Hantaan virus polymerase into symmetric dimers and hexamers
by: Quentin Durieux Trouilleton, et al.
Published: (2024-03-01)

Investigating Influenza Virus Polymerase Activity in Feline Cells Based on the Influenza Virus Minigenome Replication System Driven by the Feline RNA Polymerase I Promoter
by: Gang Lu, et al.
Published: (2022-05-01)

Recruitment of RED-SMU1 complex by Influenza A Virus RNA polymerase to control Viral mRNA splicing.
by: Guillaume Fournier, et al.
Published: (2014-06-01)

Structures of influenza A virus RNA polymerase offer insight into viral genome replication
by: Fan, H, et al.
Published: (2019)

The host-dependent interaction of alpha-importins with influenza PB2 polymerase subunit is required for virus RNA replication.
by: Patricia Resa-Infante, et al.
Published: (2008-01-01)

RNA-free and ribonucleoprotein-associated influenza virus polymerases directly bind the serine-5 phosphorylated carboxyl-terminal domain of host RNA polymerase II
by: Fodor, E, et al.
Published: (2016)

Cepharanthine inhibits influenza A virus replication by impairing viral polymerase activity and regulating influenza-induced immune response
by: Yinyan Li, et al.
Published: (2024-05-01)

The dynamic proteome of influenza A virus infection identifies M segment splicing as a host range determinant
by: Boris Bogdanow, et al.
Published: (2019-12-01)

Influenza virus ribonucleoprotein complexes gain preferential access to cellular export machinery through chromatin targeting.
by: Geoffrey P Chase, et al.
Published: (2011-09-01)

DNA elongation by the human DNA polymerase lambda polymerase and terminal transferase activities are differentially coordinated by proliferating cell nuclear antigen and replication protein A.
by: Maga, G, et al.
Published: (2005)

Structures of H5N1 influenza polymerase with ANP32B reveal mechanisms of genome replication and host adaptation
by: Staller, E, et al.
Published: (2024)

Semisynthetic Cardenolides Acting as Antiviral Inhibitors of Influenza A Virus Replication by Preventing Polymerase Complex Formation
by: Laurita Boff, et al.
Published: (2020-10-01)

Epistatic Interactions within the Influenza A Virus Polymerase Complex Mediate Mutagen Resistance and Replication Fidelity
by: Matthew D. Pauly, et al.
Published: (2017-08-01)

Replicative DNA polymerase mutations in cancer
by: Heitzer, E, et al.
Published: (2014)

Replicative DNA polymerase mutations in cancer.
by: Heitzer, E, et al.
Published: (2014)

Crystal structure of the RNA-dependent RNA polymerase from influenza C virus.
by: Hengrung, N, et al.
Published: (2015)

The replication fork trap and termination of chromosome replication.
by: Duggin, I, et al.
Published: (2008)

Sumoylation of the Carboxy-Terminal of Human Cytomegalovirus DNA Polymerase Processivity Factor UL44 Attenuates Viral DNA Replication
by: Jun Chen, et al.
Published: (2021-04-01)

The surface-exposed PA51-72-loop of the influenza A virus polymerase is required for viral genome replication
by: Nilsson-Payant, B, et al.
Published: (2018)

The PA Subunit of the Influenza Virus Polymerase Complex Affects Replication and Airborne Transmission of the H9N2 Subtype Avian Influenza Virus
by: Mengchan Hao, et al.
Published: (2019-01-01)

Transcription termination by RNA Polymerase II
by: White, E
Published: (2012)

Disengaging polymerase: terminating RNA polymerase II transcription in budding yeast.
by: Mischo, H, et al.
Published: (2013)

Evolution of replicative DNA polymerases in archaea and their contributions to the eukaryotic replication machinery
by: Kira S Makarova, et al.
Published: (2014-07-01)

Molecular basis of host-adaptation interactions between influenza virus polymerase PB2 subunit and ANP32A
by: Aldo R. Camacho-Zarco, et al.
Published: (2020-07-01)

ACTIVE POLYMERASES FIXED IN REPLICATION AND TRANSCRIPTION FACTORIES
by: Hassan, B, et al.
Published: (1994)

A global profile of replicative polymerase usage.
by: Daigaku, Y, et al.
Published: (2015)