SCUBE3 downregulation modulates hepatocellular carcinoma by inhibiting CCNE1 via TGFβ/PI3K/AKT/GSK3β pathway

SCUBE3 downregulation modulates hepatocellular carcinoma by inhibiting CCNE1 via TGFβ/PI3K/AKT/GSK3β pathway

Abstract Objectives We aimed to verify the role of signal peptide-CUB-EGF-like domain-containing protein3 (SCUBE3) in the hepatocellular carcinoma (HCC) progression. Methods The role of SCUBE3 in HCC cell proliferation, apoptosis, and cell cycle in vitro were detected using MTT assay, colony formati...

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Bibliographic Details
Main Authors: Pan Xu, Aoran Luo, Chuan Xiong, Hong Ren, Liang Yan, Qiang Luo
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Cancer Cell International
Subjects:
Hepatocellular carcinoma
SCUBE3
AKT
CCNE1
Cell proliferation
Online Access:https://doi.org/10.1186/s12935-021-02402-z

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