Propionic Acid Targets the TLR4/NF-κB Signaling Pathway and Inhibits LPS-Induced Intestinal Barrier Dysfunction: In Vitro and In Vivo Studies

Propionic Acid Targets the TLR4/NF-κB Signaling Pathway and Inhibits LPS-Induced Intestinal Barrier Dysfunction: In Vitro and In Vivo Studies

Intestinal barrier dysfunction contributes to the development of intestinal diseases. Propionic acid (PA), a metabolite generated by anaerobic fermentation of dietary fiber in the intestinal cavity, has been proved to exert anti-inflammatory effects in a variety of diseases. However, the exact role...

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Bibliographic Details
Main Authors:	Randong Yang, Xiaoxiao Hu, Xianzheng Xie, Haiqiong Chen, Huangyi Fang, Libing Zhu, Zhongrong Li
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-09-01
Series:	Frontiers in Pharmacology
Subjects:	propionic acid lipopolysaccharide intestinal barrier cell migration NLRP3 inflammasome
Online Access:	https://www.frontiersin.org/article/10.3389/fphar.2020.573475/full

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