Interleukin-10: A double-edged sword in breast cancer
Breast cancer (BC) is a frequently diagnosed cancer among women worldwide. Currently, BC can be divided into different subgroups according to the presence of the following hormone receptors: estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. Each of these subgrou...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2021-01-01
|
| Series: | Tzu-Chi Medical Journal |
| Subjects: | |
| Online Access: | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2021;volume=33;issue=3;spage=203;epage=211;aulast=Chang |
| _version_ | 1818864797179969536 |
|---|---|
| author | Chun-Ming Chang Ho Yin Pekkle Lam Hao-Jen Hsu Shinn-Jong Jiang |
| author_facet | Chun-Ming Chang Ho Yin Pekkle Lam Hao-Jen Hsu Shinn-Jong Jiang |
| author_sort | Chun-Ming Chang |
| collection | DOAJ |
| description | Breast cancer (BC) is a frequently diagnosed cancer among women worldwide. Currently, BC can be divided into different subgroups according to the presence of the following hormone receptors: estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. Each of these subgroups has different treatment strategies. However, the presence of new metastatic lesions and patient deterioration suggest resistance to a given treatment. Various lines of evidence had shown that cytokines are one of the important mediators of tumor growth, invasion, metastasis, and treatment resistance. Interleukin-10 (IL-10) is an immunoregulatory cytokine, and acts as a poor prognostic marker in many cancers. The anti-inflammatory IL-10 blocks certain effects of inflammatory cytokines. It also antagonizes the co-stimulatory molecules on the antigen-presenting cells. Here, we review the current knowledge on the function and molecular mechanism of IL-10, and recent findings on how IL-10 contributes to the progression of BC. |
| first_indexed | 2024-12-19T10:37:22Z |
| format | Article |
| id | doaj.art-b3875fb586bb4c069dd41e51a2a86913 |
| institution | Directory Open Access Journal |
| issn | 1016-3190 2223-8956 |
| language | English |
| last_indexed | 2024-12-19T10:37:22Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Tzu-Chi Medical Journal |
| spelling | doaj.art-b3875fb586bb4c069dd41e51a2a869132022-12-21T20:25:34ZengWolters Kluwer Medknow PublicationsTzu-Chi Medical Journal1016-31902223-89562021-01-0133320321110.4103/tcmj.tcmj_162_20Interleukin-10: A double-edged sword in breast cancerChun-Ming ChangHo Yin Pekkle LamHao-Jen HsuShinn-Jong JiangBreast cancer (BC) is a frequently diagnosed cancer among women worldwide. Currently, BC can be divided into different subgroups according to the presence of the following hormone receptors: estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. Each of these subgroups has different treatment strategies. However, the presence of new metastatic lesions and patient deterioration suggest resistance to a given treatment. Various lines of evidence had shown that cytokines are one of the important mediators of tumor growth, invasion, metastasis, and treatment resistance. Interleukin-10 (IL-10) is an immunoregulatory cytokine, and acts as a poor prognostic marker in many cancers. The anti-inflammatory IL-10 blocks certain effects of inflammatory cytokines. It also antagonizes the co-stimulatory molecules on the antigen-presenting cells. Here, we review the current knowledge on the function and molecular mechanism of IL-10, and recent findings on how IL-10 contributes to the progression of BC.http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2021;volume=33;issue=3;spage=203;epage=211;aulast=Changbreast cancercytokineinterleukin-10tumor microenvironment |
| spellingShingle | Chun-Ming Chang Ho Yin Pekkle Lam Hao-Jen Hsu Shinn-Jong Jiang Interleukin-10: A double-edged sword in breast cancer Tzu-Chi Medical Journal breast cancer cytokine interleukin-10 tumor microenvironment |
| title | Interleukin-10: A double-edged sword in breast cancer |
| title_full | Interleukin-10: A double-edged sword in breast cancer |
| title_fullStr | Interleukin-10: A double-edged sword in breast cancer |
| title_full_unstemmed | Interleukin-10: A double-edged sword in breast cancer |
| title_short | Interleukin-10: A double-edged sword in breast cancer |
| title_sort | interleukin 10 a double edged sword in breast cancer |
| topic | breast cancer cytokine interleukin-10 tumor microenvironment |
| url | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2021;volume=33;issue=3;spage=203;epage=211;aulast=Chang |
| work_keys_str_mv | AT chunmingchang interleukin10adoubleedgedswordinbreastcancer AT hoyinpekklelam interleukin10adoubleedgedswordinbreastcancer AT haojenhsu interleukin10adoubleedgedswordinbreastcancer AT shinnjongjiang interleukin10adoubleedgedswordinbreastcancer |