Peripheral and central sensitization
ABSTRACT BACKGROUND AND OBJECTIVES: Central sensitization is an important phenomenon for pain chronicity and is present in neuropathic pain. This study aimed at addressing some pathophysiological aspects of this phenomenon. CONTENTS: Some extra and intracellular aspects responsible for central sen...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira para o Estudo da Dor
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| Series: | Revista Dor |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-00132016000500031&lng=en&tlng=en |
| _version_ | 1819025773415104512 |
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| author | Hazem Adel Ashmawi George Miguel Góes Freire |
| author_facet | Hazem Adel Ashmawi George Miguel Góes Freire |
| author_sort | Hazem Adel Ashmawi |
| collection | DOAJ |
| description | ABSTRACT BACKGROUND AND OBJECTIVES: Central sensitization is an important phenomenon for pain chronicity and is present in neuropathic pain. This study aimed at addressing some pathophysiological aspects of this phenomenon. CONTENTS: Some extra and intracellular aspects responsible for central sensitization genesis, especially phenotypic changes in plasticity of neurons involved in the process are described. CONCLUSION: Pain chronicity may result from changes in central nervous system neurons properties by the central sensitization phenomenon with constant changes in membrane excitability, inhibitory transmission reduction and increase in synaptic efficacy mediated by several convergent and divergent molecular mechanisms over a background of phenotypic and structural changes. Neuroplasticity deeply alters painful sensation, contributing for many clinical painful syndromes and may represent a major target for therapeutic intervention. |
| first_indexed | 2024-12-21T05:16:00Z |
| format | Article |
| id | doaj.art-b38a241162a7453fb8248838b76e74d7 |
| institution | Directory Open Access Journal |
| issn | 1806-0013 2317-6393 |
| language | English |
| last_indexed | 2024-12-21T05:16:00Z |
| publisher | Sociedade Brasileira para o Estudo da Dor |
| record_format | Article |
| series | Revista Dor |
| spelling | doaj.art-b38a241162a7453fb8248838b76e74d72022-12-21T19:14:56ZengSociedade Brasileira para o Estudo da DorRevista Dor1806-00132317-639317suppl 1313410.5935/1806-0013.20160044S1806-00132016000500031Peripheral and central sensitizationHazem Adel AshmawiGeorge Miguel Góes FreireABSTRACT BACKGROUND AND OBJECTIVES: Central sensitization is an important phenomenon for pain chronicity and is present in neuropathic pain. This study aimed at addressing some pathophysiological aspects of this phenomenon. CONTENTS: Some extra and intracellular aspects responsible for central sensitization genesis, especially phenotypic changes in plasticity of neurons involved in the process are described. CONCLUSION: Pain chronicity may result from changes in central nervous system neurons properties by the central sensitization phenomenon with constant changes in membrane excitability, inhibitory transmission reduction and increase in synaptic efficacy mediated by several convergent and divergent molecular mechanisms over a background of phenotypic and structural changes. Neuroplasticity deeply alters painful sensation, contributing for many clinical painful syndromes and may represent a major target for therapeutic intervention.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-00132016000500031&lng=en&tlng=endor neuropáticaionóforosplasticidade neuronalsensibilização central |
| spellingShingle | Hazem Adel Ashmawi George Miguel Góes Freire Peripheral and central sensitization Revista Dor dor neuropática ionóforos plasticidade neuronal sensibilização central |
| title | Peripheral and central sensitization |
| title_full | Peripheral and central sensitization |
| title_fullStr | Peripheral and central sensitization |
| title_full_unstemmed | Peripheral and central sensitization |
| title_short | Peripheral and central sensitization |
| title_sort | peripheral and central sensitization |
| topic | dor neuropática ionóforos plasticidade neuronal sensibilização central |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-00132016000500031&lng=en&tlng=en |
| work_keys_str_mv | AT hazemadelashmawi peripheralandcentralsensitization AT georgemiguelgoesfreire peripheralandcentralsensitization |