Red yeast rice induces less muscle fatigue symptom than simvastatin in dyslipidemic patients: a single center randomized pilot trial
Abstract Background About 10–15% patients who take statins experience skeletal muscle problems. Red yeast rice has a good safety profile could provide a compromise therapeutic strategy. Therefore, the aim of this study was to evaluate the effects of red yeast rice, when compared to simvastatin, on t...
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| Format: | Article |
| Language: | English |
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BMC
2017-05-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | http://link.springer.com/article/10.1186/s12872-017-0560-z |
| _version_ | 1818081175340580864 |
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| author | Yangjing Xue Luyuan Tao Shaoze Wu Guoqiang Wang Lu Qian Jiwu Li Lianming Liao Jifei Tang Kangting Ji |
| author_facet | Yangjing Xue Luyuan Tao Shaoze Wu Guoqiang Wang Lu Qian Jiwu Li Lianming Liao Jifei Tang Kangting Ji |
| author_sort | Yangjing Xue |
| collection | DOAJ |
| description | Abstract Background About 10–15% patients who take statins experience skeletal muscle problems. Red yeast rice has a good safety profile could provide a compromise therapeutic strategy. Therefore, the aim of this study was to evaluate the effects of red yeast rice, when compared to simvastatin, on the muscle fatigue symptom and the serum lipid level in dyslipidemic patients with low to moderate cardiovascular risk. Methods A total of 60 dyslipidemic patients with low to moderate cardiovascular risk were recruited and randomly assigned to receive either simvastatin (n = 33) or red yeast rice (n = 27) for 4 weeks. The muscle fatigue score, the physical activity, the serum lipid profile and the safety profile were then evaluated. Results At the end of study, the fatigue score was significantly increased in patients treated with simvastatin, whereas no significant change was observed in patients receiving red yeast rice. In addition, the physical activity level was significantly decreased in patients from simvastatin group when compared to those from red yeast rice group. Similar lipid-lowering effects were observed in two groups. The safety profile was not affected after the treatments. Conclusions Among dyslipidemic patients with low to moderate cardiovascular risk, red yeast rice induced less fatigue side effect and exerted comparable lipid-lowering effects when compared to simvastatin in this pilot primary prevention study. Trial registration NCT01686451 . |
| first_indexed | 2024-12-10T19:02:02Z |
| format | Article |
| id | doaj.art-b38b09e70639471d9616e5b3ef1aed42 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-12-10T19:02:02Z |
| publishDate | 2017-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-b38b09e70639471d9616e5b3ef1aed422022-12-22T01:36:59ZengBMCBMC Cardiovascular Disorders1471-22612017-05-011711710.1186/s12872-017-0560-zRed yeast rice induces less muscle fatigue symptom than simvastatin in dyslipidemic patients: a single center randomized pilot trialYangjing Xue0Luyuan Tao1Shaoze Wu2Guoqiang Wang3Lu Qian4Jiwu Li5Lianming Liao6Jifei Tang7Kangting Ji8Department of Cardiology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityDepartment of Cardiology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityDepartment of Cardiology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityDepartment of Cardiology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityDepartment of Cardiology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityDepartment of Cardiology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityDepartment of Oncology, Academy of Integrative Medicine, Fujian University of Traditional Chinese MedicineDepartment of Cardiology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityDepartment of Cardiology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityAbstract Background About 10–15% patients who take statins experience skeletal muscle problems. Red yeast rice has a good safety profile could provide a compromise therapeutic strategy. Therefore, the aim of this study was to evaluate the effects of red yeast rice, when compared to simvastatin, on the muscle fatigue symptom and the serum lipid level in dyslipidemic patients with low to moderate cardiovascular risk. Methods A total of 60 dyslipidemic patients with low to moderate cardiovascular risk were recruited and randomly assigned to receive either simvastatin (n = 33) or red yeast rice (n = 27) for 4 weeks. The muscle fatigue score, the physical activity, the serum lipid profile and the safety profile were then evaluated. Results At the end of study, the fatigue score was significantly increased in patients treated with simvastatin, whereas no significant change was observed in patients receiving red yeast rice. In addition, the physical activity level was significantly decreased in patients from simvastatin group when compared to those from red yeast rice group. Similar lipid-lowering effects were observed in two groups. The safety profile was not affected after the treatments. Conclusions Among dyslipidemic patients with low to moderate cardiovascular risk, red yeast rice induced less fatigue side effect and exerted comparable lipid-lowering effects when compared to simvastatin in this pilot primary prevention study. Trial registration NCT01686451 .http://link.springer.com/article/10.1186/s12872-017-0560-zMuscle fatigue symptomPhysical activityRed yeast riceSimvastatinDyslipidemiaLipid-lowering effects |
| spellingShingle | Yangjing Xue Luyuan Tao Shaoze Wu Guoqiang Wang Lu Qian Jiwu Li Lianming Liao Jifei Tang Kangting Ji Red yeast rice induces less muscle fatigue symptom than simvastatin in dyslipidemic patients: a single center randomized pilot trial BMC Cardiovascular Disorders Muscle fatigue symptom Physical activity Red yeast rice Simvastatin Dyslipidemia Lipid-lowering effects |
| title | Red yeast rice induces less muscle fatigue symptom than simvastatin in dyslipidemic patients: a single center randomized pilot trial |
| title_full | Red yeast rice induces less muscle fatigue symptom than simvastatin in dyslipidemic patients: a single center randomized pilot trial |
| title_fullStr | Red yeast rice induces less muscle fatigue symptom than simvastatin in dyslipidemic patients: a single center randomized pilot trial |
| title_full_unstemmed | Red yeast rice induces less muscle fatigue symptom than simvastatin in dyslipidemic patients: a single center randomized pilot trial |
| title_short | Red yeast rice induces less muscle fatigue symptom than simvastatin in dyslipidemic patients: a single center randomized pilot trial |
| title_sort | red yeast rice induces less muscle fatigue symptom than simvastatin in dyslipidemic patients a single center randomized pilot trial |
| topic | Muscle fatigue symptom Physical activity Red yeast rice Simvastatin Dyslipidemia Lipid-lowering effects |
| url | http://link.springer.com/article/10.1186/s12872-017-0560-z |
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