Mid-term safety and effectiveness of macular peeling one month after intravitreal dexamethasone implant for tractional diabetic macular edema
Abstract Macular peeling combined or followed by intravitreal dexamethasone implant (DEX-i) was recommended as an efficacy approach for tractional diabetic macular edema (tDME). Knowing the synergistic effect of cataract surgery and DEX-i one month earlier in eyes with DME, we compared Epiretinal Me...
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-32780-5 |
| _version_ | 1797845962792632320 |
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| author | Francesco Pignatelli Alfredo Niro Matteo Fallico Fedele Passidomo Samuele Gigliola Annalisa Nacucchi Vincenza Bonfiglio Michele Reibaldi Giuseppe Addabbo Teresio Avitabile |
| author_facet | Francesco Pignatelli Alfredo Niro Matteo Fallico Fedele Passidomo Samuele Gigliola Annalisa Nacucchi Vincenza Bonfiglio Michele Reibaldi Giuseppe Addabbo Teresio Avitabile |
| author_sort | Francesco Pignatelli |
| collection | DOAJ |
| description | Abstract Macular peeling combined or followed by intravitreal dexamethasone implant (DEX-i) was recommended as an efficacy approach for tractional diabetic macular edema (tDME). Knowing the synergistic effect of cataract surgery and DEX-i one month earlier in eyes with DME, we compared Epiretinal Membrane/Inner Limiting Membrane (ERM/ILM) peeling preceded by DEX-i one month before versus ERM/ILM peeling alone for the treatment of tDME. A retrospective study on patients affected by tDME who underwent ERM/ILM peeling one month after DEX-i (n = 11; Group A) or ERM/ILM peeling alone (n = 10; Group B) was performed. Longitudinal comparison of best-correct visual acuity (BCVA), central retinal thickness (CRT), and intraocular pressure (IOP) between the time of surgery (T0) and each time point (months 1,3,5,6) within and among the groups were assessed. To evaluate the repeated measurements of BCVA, CRT, and IOP, a linear mixed-effects model was used. In Group A, DEX-i significantly improved mean BCVA and CRT (P < 0.001) just after 1 month (T0). After ERM/ILM peeling, mean BCVA and CRT significantly improved from month 1 in Group A and month 3 in Group B. Mixed model revealed a significant difference in BCVA (P ≤ 0.0001) and CRT (P ≤ 0.02) at different time-points among the groups with better results in Group A. Neither complications nor uncontrolled IOP increase was detected. ERM/ILM peeling confirmed its effectiveness in treating tDME. DEX-i performed one month before surgery seemed to be a safe approach and ensured a greater and faster recovery considering functional and tomographic parameters. |
| first_indexed | 2024-04-09T17:48:30Z |
| format | Article |
| id | doaj.art-b38c43f45ff249e884117b89ffecc670 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T17:48:30Z |
| publishDate | 2023-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-b38c43f45ff249e884117b89ffecc6702023-04-16T11:13:33ZengNature PortfolioScientific Reports2045-23222023-04-011311910.1038/s41598-023-32780-5Mid-term safety and effectiveness of macular peeling one month after intravitreal dexamethasone implant for tractional diabetic macular edemaFrancesco Pignatelli0Alfredo Niro1Matteo Fallico2Fedele Passidomo3Samuele Gigliola4Annalisa Nacucchi5Vincenza Bonfiglio6Michele Reibaldi7Giuseppe Addabbo8Teresio Avitabile9Eye Clinic, Hospital “SS. Annunziata”, ASL TAEye Clinic, Hospital “SS. Annunziata”, ASL TADepartment of Ophthalmology, University of CataniaEye Clinic, Hospital “SS. Annunziata”, ASL TAEye Clinic, Hospital “SS. Annunziata”, ASL TAEye Clinic, Hospital “SS. Annunziata”, ASL TADepartment of Experimental Biomedicine and Clinical Neuroscience, University of PalermoDepartment of Surgical Sciences, Eye Clinic Section, University of TurinEye Clinic, Hospital “SS. Annunziata”, ASL TADepartment of Ophthalmology, University of CataniaAbstract Macular peeling combined or followed by intravitreal dexamethasone implant (DEX-i) was recommended as an efficacy approach for tractional diabetic macular edema (tDME). Knowing the synergistic effect of cataract surgery and DEX-i one month earlier in eyes with DME, we compared Epiretinal Membrane/Inner Limiting Membrane (ERM/ILM) peeling preceded by DEX-i one month before versus ERM/ILM peeling alone for the treatment of tDME. A retrospective study on patients affected by tDME who underwent ERM/ILM peeling one month after DEX-i (n = 11; Group A) or ERM/ILM peeling alone (n = 10; Group B) was performed. Longitudinal comparison of best-correct visual acuity (BCVA), central retinal thickness (CRT), and intraocular pressure (IOP) between the time of surgery (T0) and each time point (months 1,3,5,6) within and among the groups were assessed. To evaluate the repeated measurements of BCVA, CRT, and IOP, a linear mixed-effects model was used. In Group A, DEX-i significantly improved mean BCVA and CRT (P < 0.001) just after 1 month (T0). After ERM/ILM peeling, mean BCVA and CRT significantly improved from month 1 in Group A and month 3 in Group B. Mixed model revealed a significant difference in BCVA (P ≤ 0.0001) and CRT (P ≤ 0.02) at different time-points among the groups with better results in Group A. Neither complications nor uncontrolled IOP increase was detected. ERM/ILM peeling confirmed its effectiveness in treating tDME. DEX-i performed one month before surgery seemed to be a safe approach and ensured a greater and faster recovery considering functional and tomographic parameters.https://doi.org/10.1038/s41598-023-32780-5 |
| spellingShingle | Francesco Pignatelli Alfredo Niro Matteo Fallico Fedele Passidomo Samuele Gigliola Annalisa Nacucchi Vincenza Bonfiglio Michele Reibaldi Giuseppe Addabbo Teresio Avitabile Mid-term safety and effectiveness of macular peeling one month after intravitreal dexamethasone implant for tractional diabetic macular edema Scientific Reports |
| title | Mid-term safety and effectiveness of macular peeling one month after intravitreal dexamethasone implant for tractional diabetic macular edema |
| title_full | Mid-term safety and effectiveness of macular peeling one month after intravitreal dexamethasone implant for tractional diabetic macular edema |
| title_fullStr | Mid-term safety and effectiveness of macular peeling one month after intravitreal dexamethasone implant for tractional diabetic macular edema |
| title_full_unstemmed | Mid-term safety and effectiveness of macular peeling one month after intravitreal dexamethasone implant for tractional diabetic macular edema |
| title_short | Mid-term safety and effectiveness of macular peeling one month after intravitreal dexamethasone implant for tractional diabetic macular edema |
| title_sort | mid term safety and effectiveness of macular peeling one month after intravitreal dexamethasone implant for tractional diabetic macular edema |
| url | https://doi.org/10.1038/s41598-023-32780-5 |
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