Malnutrition and cerebral intraparenchymal damage in patients with thrombosis of dural sinuses and/or cerebral veins
Abstract Backgrounds Thrombosis of dural sinuses and/or cerebral veins (CVT) is an uncommon form of cerebrovascular disease. Malnutrition is common in patients with cerebrovascular disease, and early assessment of malnutrition and individualized nutritional treatment have been reported to improve fu...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-12-01
|
| Series: | BMC Neurology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12883-023-03491-1 |
| _version_ | 1797376928776192000 |
|---|---|
| author | Weiwei Xiang Yangyang Liang Zhibo Chen Hanmin Wang Yangtai Guan Dewei Xie |
| author_facet | Weiwei Xiang Yangyang Liang Zhibo Chen Hanmin Wang Yangtai Guan Dewei Xie |
| author_sort | Weiwei Xiang |
| collection | DOAJ |
| description | Abstract Backgrounds Thrombosis of dural sinuses and/or cerebral veins (CVT) is an uncommon form of cerebrovascular disease. Malnutrition is common in patients with cerebrovascular disease, and early assessment of malnutrition and individualized nutritional treatment have been reported to improve functional outcomes of these patients. As for CVT patients, little is known about whether these patients would suffer from malnutrition. Also, the correlation between malnutrition and cerebral intraparenchymal damage (CID) in CVT patients was rarely studied. Methods Patients with CVT were retrospectively included in this observational study. Multivariate logistic regressions were used to investigate the effects of nutritional indexes on the risk of CID. Subsequently, we used the independent risk factors to construct the nomogram model, and the consistency index (C-index), calibration curve and decision curve analysis (DCA) to assess the reliability and applicability of the model. Results A total of 165 patients were included in the final analysis. Approximately 72.7% of CVT patients were regarded as malnourished by our malnutrition screening tools, and malnutrition is associated with an increased risk of CID. Prognostic Nutritional Index (PNI) (OR = 0.873; CI: 0.791, 0.963, p = 0.007) remained as an independent predictor for CID after adjustment for other risk factors. The nomogram model showed that PNI and gender have a great contribution to prediction. Besides, the nomogram model was consistent with the actual observations of CID risk (C-index = 0.65) and was of clinical significance. Conclusions We reported that malnutrition, as indicated by PNI, was associated with a higher incidence of CID in CVT patients. Also, we have constructed a nomogram for predicting the risk of CID in these patients. |
| first_indexed | 2024-03-08T19:45:40Z |
| format | Article |
| id | doaj.art-b38c697ed22f4dada65ed4702d412a48 |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-03-08T19:45:40Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-b38c697ed22f4dada65ed4702d412a482023-12-24T12:22:19ZengBMCBMC Neurology1471-23772023-12-012311910.1186/s12883-023-03491-1Malnutrition and cerebral intraparenchymal damage in patients with thrombosis of dural sinuses and/or cerebral veinsWeiwei Xiang0Yangyang Liang1Zhibo Chen2Hanmin Wang3Yangtai Guan4Dewei Xie5Department of Neurology, Ren Ji Hospital, Shanghai Jiao Tong University School of MedicineThe College of Renji, Wenzhou Medical UniversityDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical UniversityDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical UniversityDepartment of Neurology, Ren Ji Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical UniversityAbstract Backgrounds Thrombosis of dural sinuses and/or cerebral veins (CVT) is an uncommon form of cerebrovascular disease. Malnutrition is common in patients with cerebrovascular disease, and early assessment of malnutrition and individualized nutritional treatment have been reported to improve functional outcomes of these patients. As for CVT patients, little is known about whether these patients would suffer from malnutrition. Also, the correlation between malnutrition and cerebral intraparenchymal damage (CID) in CVT patients was rarely studied. Methods Patients with CVT were retrospectively included in this observational study. Multivariate logistic regressions were used to investigate the effects of nutritional indexes on the risk of CID. Subsequently, we used the independent risk factors to construct the nomogram model, and the consistency index (C-index), calibration curve and decision curve analysis (DCA) to assess the reliability and applicability of the model. Results A total of 165 patients were included in the final analysis. Approximately 72.7% of CVT patients were regarded as malnourished by our malnutrition screening tools, and malnutrition is associated with an increased risk of CID. Prognostic Nutritional Index (PNI) (OR = 0.873; CI: 0.791, 0.963, p = 0.007) remained as an independent predictor for CID after adjustment for other risk factors. The nomogram model showed that PNI and gender have a great contribution to prediction. Besides, the nomogram model was consistent with the actual observations of CID risk (C-index = 0.65) and was of clinical significance. Conclusions We reported that malnutrition, as indicated by PNI, was associated with a higher incidence of CID in CVT patients. Also, we have constructed a nomogram for predicting the risk of CID in these patients.https://doi.org/10.1186/s12883-023-03491-1MalnutritionCVTCerebral intraparenchymal damageNomogram |
| spellingShingle | Weiwei Xiang Yangyang Liang Zhibo Chen Hanmin Wang Yangtai Guan Dewei Xie Malnutrition and cerebral intraparenchymal damage in patients with thrombosis of dural sinuses and/or cerebral veins BMC Neurology Malnutrition CVT Cerebral intraparenchymal damage Nomogram |
| title | Malnutrition and cerebral intraparenchymal damage in patients with thrombosis of dural sinuses and/or cerebral veins |
| title_full | Malnutrition and cerebral intraparenchymal damage in patients with thrombosis of dural sinuses and/or cerebral veins |
| title_fullStr | Malnutrition and cerebral intraparenchymal damage in patients with thrombosis of dural sinuses and/or cerebral veins |
| title_full_unstemmed | Malnutrition and cerebral intraparenchymal damage in patients with thrombosis of dural sinuses and/or cerebral veins |
| title_short | Malnutrition and cerebral intraparenchymal damage in patients with thrombosis of dural sinuses and/or cerebral veins |
| title_sort | malnutrition and cerebral intraparenchymal damage in patients with thrombosis of dural sinuses and or cerebral veins |
| topic | Malnutrition CVT Cerebral intraparenchymal damage Nomogram |
| url | https://doi.org/10.1186/s12883-023-03491-1 |
| work_keys_str_mv | AT weiweixiang malnutritionandcerebralintraparenchymaldamageinpatientswiththrombosisofduralsinusesandorcerebralveins AT yangyangliang malnutritionandcerebralintraparenchymaldamageinpatientswiththrombosisofduralsinusesandorcerebralveins AT zhibochen malnutritionandcerebralintraparenchymaldamageinpatientswiththrombosisofduralsinusesandorcerebralveins AT hanminwang malnutritionandcerebralintraparenchymaldamageinpatientswiththrombosisofduralsinusesandorcerebralveins AT yangtaiguan malnutritionandcerebralintraparenchymaldamageinpatientswiththrombosisofduralsinusesandorcerebralveins AT deweixie malnutritionandcerebralintraparenchymaldamageinpatientswiththrombosisofduralsinusesandorcerebralveins |