Chronic diseases associated with increased likelihood of hospitalization and mortality in 68,913 COVID-19 confirmed cases in Spain: A population-based cohort study.
<h4>Background</h4>Clinical outcomes among COVID-19 patients vary greatly with age and underlying comorbidities. We aimed to determine the demographic and clinical factors, particularly baseline chronic conditions, associated with an increased risk of severity in COVID-19 patients from a...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0259822 |
| _version_ | 1818342784648609792 |
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| author | Antonio Gimeno-Miguel Kevin Bliek-Bueno Beatriz Poblador-Plou Jonás Carmona-Pírez Antonio Poncel-Falcó Francisca González-Rubio Ignatios Ioakeim-Skoufa Victoria Pico-Soler Mercedes Aza-Pascual-Salcedo Alexandra Prados-Torres Luis Andrés Gimeno-Feliu PRECOVID Group |
| author_facet | Antonio Gimeno-Miguel Kevin Bliek-Bueno Beatriz Poblador-Plou Jonás Carmona-Pírez Antonio Poncel-Falcó Francisca González-Rubio Ignatios Ioakeim-Skoufa Victoria Pico-Soler Mercedes Aza-Pascual-Salcedo Alexandra Prados-Torres Luis Andrés Gimeno-Feliu PRECOVID Group |
| author_sort | Antonio Gimeno-Miguel |
| collection | DOAJ |
| description | <h4>Background</h4>Clinical outcomes among COVID-19 patients vary greatly with age and underlying comorbidities. We aimed to determine the demographic and clinical factors, particularly baseline chronic conditions, associated with an increased risk of severity in COVID-19 patients from a population-based perspective and using data from electronic health records (EHR).<h4>Methods</h4>Retrospective, observational study in an open cohort analyzing all 68,913 individuals (mean age 44.4 years, 53.2% women) with SARS-CoV-2 infection between 15 June and 19 December 2020 using exhaustive electronic health registries. Patients were followed for 30 days from inclusion or until the date of death within that period. We performed multivariate logistic regression to analyze the association between each chronic disease and severe infection, based on hospitalization and all-cause mortality.<h4>Results</h4>5885 (8.5%) individuals showed severe infection and old age was the most influencing factor. Congestive heart failure (odds ratio -OR- men: 1.28, OR women: 1.39), diabetes (1.37, 1.24), chronic renal failure (1.31, 1.22) and obesity (1.21, 1.26) increased the likelihood of severe infection in both sexes. Chronic skin ulcers (1.32), acute cerebrovascular disease (1.34), chronic obstructive pulmonary disease (1.21), urinary incontinence (1.17) and neoplasms (1.26) in men, and infertility (1.87), obstructive sleep apnea (1.43), hepatic steatosis (1.43), rheumatoid arthritis (1.39) and menstrual disorders (1.18) in women were also associated with more severe outcomes.<h4>Conclusions</h4>Age and specific cardiovascular and metabolic diseases increased the risk of severe SARS-CoV-2 infections in men and women, whereas the effects of certain comorbidities are sex specific. Future studies in different settings are encouraged to analyze which profiles of chronic patients are at higher risk of poor prognosis and should therefore be the targets of prevention and shielding strategies. |
| first_indexed | 2024-12-13T16:20:12Z |
| format | Article |
| id | doaj.art-b38d0386fb904f4eace819db5f3e670c |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T16:20:12Z |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-b38d0386fb904f4eace819db5f3e670c2022-12-21T23:38:44ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-011611e025982210.1371/journal.pone.0259822Chronic diseases associated with increased likelihood of hospitalization and mortality in 68,913 COVID-19 confirmed cases in Spain: A population-based cohort study.Antonio Gimeno-MiguelKevin Bliek-BuenoBeatriz Poblador-PlouJonás Carmona-PírezAntonio Poncel-FalcóFrancisca González-RubioIgnatios Ioakeim-SkoufaVictoria Pico-SolerMercedes Aza-Pascual-SalcedoAlexandra Prados-TorresLuis Andrés Gimeno-FeliuPRECOVID Group<h4>Background</h4>Clinical outcomes among COVID-19 patients vary greatly with age and underlying comorbidities. We aimed to determine the demographic and clinical factors, particularly baseline chronic conditions, associated with an increased risk of severity in COVID-19 patients from a population-based perspective and using data from electronic health records (EHR).<h4>Methods</h4>Retrospective, observational study in an open cohort analyzing all 68,913 individuals (mean age 44.4 years, 53.2% women) with SARS-CoV-2 infection between 15 June and 19 December 2020 using exhaustive electronic health registries. Patients were followed for 30 days from inclusion or until the date of death within that period. We performed multivariate logistic regression to analyze the association between each chronic disease and severe infection, based on hospitalization and all-cause mortality.<h4>Results</h4>5885 (8.5%) individuals showed severe infection and old age was the most influencing factor. Congestive heart failure (odds ratio -OR- men: 1.28, OR women: 1.39), diabetes (1.37, 1.24), chronic renal failure (1.31, 1.22) and obesity (1.21, 1.26) increased the likelihood of severe infection in both sexes. Chronic skin ulcers (1.32), acute cerebrovascular disease (1.34), chronic obstructive pulmonary disease (1.21), urinary incontinence (1.17) and neoplasms (1.26) in men, and infertility (1.87), obstructive sleep apnea (1.43), hepatic steatosis (1.43), rheumatoid arthritis (1.39) and menstrual disorders (1.18) in women were also associated with more severe outcomes.<h4>Conclusions</h4>Age and specific cardiovascular and metabolic diseases increased the risk of severe SARS-CoV-2 infections in men and women, whereas the effects of certain comorbidities are sex specific. Future studies in different settings are encouraged to analyze which profiles of chronic patients are at higher risk of poor prognosis and should therefore be the targets of prevention and shielding strategies.https://doi.org/10.1371/journal.pone.0259822 |
| spellingShingle | Antonio Gimeno-Miguel Kevin Bliek-Bueno Beatriz Poblador-Plou Jonás Carmona-Pírez Antonio Poncel-Falcó Francisca González-Rubio Ignatios Ioakeim-Skoufa Victoria Pico-Soler Mercedes Aza-Pascual-Salcedo Alexandra Prados-Torres Luis Andrés Gimeno-Feliu PRECOVID Group Chronic diseases associated with increased likelihood of hospitalization and mortality in 68,913 COVID-19 confirmed cases in Spain: A population-based cohort study. PLoS ONE |
| title | Chronic diseases associated with increased likelihood of hospitalization and mortality in 68,913 COVID-19 confirmed cases in Spain: A population-based cohort study. |
| title_full | Chronic diseases associated with increased likelihood of hospitalization and mortality in 68,913 COVID-19 confirmed cases in Spain: A population-based cohort study. |
| title_fullStr | Chronic diseases associated with increased likelihood of hospitalization and mortality in 68,913 COVID-19 confirmed cases in Spain: A population-based cohort study. |
| title_full_unstemmed | Chronic diseases associated with increased likelihood of hospitalization and mortality in 68,913 COVID-19 confirmed cases in Spain: A population-based cohort study. |
| title_short | Chronic diseases associated with increased likelihood of hospitalization and mortality in 68,913 COVID-19 confirmed cases in Spain: A population-based cohort study. |
| title_sort | chronic diseases associated with increased likelihood of hospitalization and mortality in 68 913 covid 19 confirmed cases in spain a population based cohort study |
| url | https://doi.org/10.1371/journal.pone.0259822 |
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