Analytical Approaches for the Determination of Buprenorphine, Methadone and Their Metabolites in Biological Matrices
The abuse of buprenorphine and methadone has grown into a rising worldwide issue. After their consumption, buprenorphine, methadone and their metabolites can be found in the human organism. Due to the difficulty in the assessment of these compounds by routine drug screening, the importance of develo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/16/5211 |
| _version_ | 1797408673019985920 |
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| author | Xiaoyue Shan Chengjian Cao Bingsheng Yang |
| author_facet | Xiaoyue Shan Chengjian Cao Bingsheng Yang |
| author_sort | Xiaoyue Shan |
| collection | DOAJ |
| description | The abuse of buprenorphine and methadone has grown into a rising worldwide issue. After their consumption, buprenorphine, methadone and their metabolites can be found in the human organism. Due to the difficulty in the assessment of these compounds by routine drug screening, the importance of developing highly sensitive analytical approaches is undeniable. Liquid chromatography tandem mass spectrometry is the preferable technique for the determination of buprenorphine, methadone and their metabolites in biological matrices including urine, plasma, nails or oral fluids. This research aims to review a critical discussion of the latest trends for the monitoring of buprenorphine, methadone and their metabolites in various biological specimens. |
| first_indexed | 2024-03-09T04:02:48Z |
| format | Article |
| id | doaj.art-b38d9ccf4cab474d8203d259cbdb12fc |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T04:02:48Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-b38d9ccf4cab474d8203d259cbdb12fc2023-12-03T14:11:35ZengMDPI AGMolecules1420-30492022-08-012716521110.3390/molecules27165211Analytical Approaches for the Determination of Buprenorphine, Methadone and Their Metabolites in Biological MatricesXiaoyue Shan0Chengjian Cao1Bingsheng Yang2Hangzhou Occupational Disease Prevention and Treatment Hospital, Hangzhou 310014, ChinaHangzhou Occupational Disease Prevention and Treatment Hospital, Hangzhou 310014, ChinaHangzhou Occupational Disease Prevention and Treatment Hospital, Hangzhou 310014, ChinaThe abuse of buprenorphine and methadone has grown into a rising worldwide issue. After their consumption, buprenorphine, methadone and their metabolites can be found in the human organism. Due to the difficulty in the assessment of these compounds by routine drug screening, the importance of developing highly sensitive analytical approaches is undeniable. Liquid chromatography tandem mass spectrometry is the preferable technique for the determination of buprenorphine, methadone and their metabolites in biological matrices including urine, plasma, nails or oral fluids. This research aims to review a critical discussion of the latest trends for the monitoring of buprenorphine, methadone and their metabolites in various biological specimens.https://www.mdpi.com/1420-3049/27/16/5211analytical methodsmethadonebuprenorphinebiological matrices |
| spellingShingle | Xiaoyue Shan Chengjian Cao Bingsheng Yang Analytical Approaches for the Determination of Buprenorphine, Methadone and Their Metabolites in Biological Matrices Molecules analytical methods methadone buprenorphine biological matrices |
| title | Analytical Approaches for the Determination of Buprenorphine, Methadone and Their Metabolites in Biological Matrices |
| title_full | Analytical Approaches for the Determination of Buprenorphine, Methadone and Their Metabolites in Biological Matrices |
| title_fullStr | Analytical Approaches for the Determination of Buprenorphine, Methadone and Their Metabolites in Biological Matrices |
| title_full_unstemmed | Analytical Approaches for the Determination of Buprenorphine, Methadone and Their Metabolites in Biological Matrices |
| title_short | Analytical Approaches for the Determination of Buprenorphine, Methadone and Their Metabolites in Biological Matrices |
| title_sort | analytical approaches for the determination of buprenorphine methadone and their metabolites in biological matrices |
| topic | analytical methods methadone buprenorphine biological matrices |
| url | https://www.mdpi.com/1420-3049/27/16/5211 |
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