Microwave assisted synthesis of 1H-tetrazole-based flavonoid derivatives and their antimicrobial activity
A series of novel tetrazole scaffolds containing chalcones 4a–e and aurones 5a–e were synthesized under conventional and microwave irradiation conditions. All the newly synthesized compounds were characterized by IR, NMR and mass spectral data. Furthermore, the title compounds were screened in vitro...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Serbian Chemical Society
2018-01-01
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| Series: | Journal of the Serbian Chemical Society |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0352-5139/2018/0352-51391800064A.pdf |
| _version_ | 1818578792695726080 |
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| author | Ashok Dongamanti Nagaraju Nalaparaju Sarasija Madderla Lakshmi Vijaya B. |
| author_facet | Ashok Dongamanti Nagaraju Nalaparaju Sarasija Madderla Lakshmi Vijaya B. |
| author_sort | Ashok Dongamanti |
| collection | DOAJ |
| description | A series of novel tetrazole scaffolds containing chalcones 4a–e and aurones 5a–e were synthesized under conventional and microwave irradiation conditions. All the newly synthesized compounds were characterized by IR, NMR and mass spectral data. Furthermore, the title compounds were screened in vitro for their antimicrobial activity against bacteria, such as Staphylococus aureus, Bacillus subtilis, Klebsiella pneumoniae and Escherichia coli, as well as fungi, such as Aspergillus niger, A. flavus and Fusarium oxysporum. Some of the compounds showed very good activity compared to standard drugs against all the tested pathogenic bacteria and fungi. |
| first_indexed | 2024-12-16T06:51:26Z |
| format | Article |
| id | doaj.art-b38dd53d1b6c447197631d38cc8a5285 |
| institution | Directory Open Access Journal |
| issn | 0352-5139 1820-7421 |
| language | English |
| last_indexed | 2024-12-16T06:51:26Z |
| publishDate | 2018-01-01 |
| publisher | Serbian Chemical Society |
| record_format | Article |
| series | Journal of the Serbian Chemical Society |
| spelling | doaj.art-b38dd53d1b6c447197631d38cc8a52852022-12-21T22:40:23ZengSerbian Chemical SocietyJournal of the Serbian Chemical Society0352-51391820-74212018-01-0183121305131310.2298/JSC170825064A0352-51391800064AMicrowave assisted synthesis of 1H-tetrazole-based flavonoid derivatives and their antimicrobial activityAshok Dongamanti0Nagaraju Nalaparaju1Sarasija Madderla2Lakshmi Vijaya B.3Osmania Universit, Department of Chemistry, DeparGreen and Medicinal Chemistry Laboratory, Hyderabad, Telangana, IndiaOsmania Universit, Department of Chemistry, DeparGreen and Medicinal Chemistry Laboratory, Hyderabad, Telangana, IndiaSatavahana University, Department of Chemistry, Karimnagar, Telangana, IndiaOsmania Universit, Department of Chemistry, DeparGreen and Medicinal Chemistry Laboratory, Hyderabad, Telangana, IndiaA series of novel tetrazole scaffolds containing chalcones 4a–e and aurones 5a–e were synthesized under conventional and microwave irradiation conditions. All the newly synthesized compounds were characterized by IR, NMR and mass spectral data. Furthermore, the title compounds were screened in vitro for their antimicrobial activity against bacteria, such as Staphylococus aureus, Bacillus subtilis, Klebsiella pneumoniae and Escherichia coli, as well as fungi, such as Aspergillus niger, A. flavus and Fusarium oxysporum. Some of the compounds showed very good activity compared to standard drugs against all the tested pathogenic bacteria and fungi.http://www.doiserbia.nb.rs/img/doi/0352-5139/2018/0352-51391800064A.pdf4-(1H-tetrazol-5-yl) benzaldehydechalconeauronemicrowave irradiationantimicrobial activity. |
| spellingShingle | Ashok Dongamanti Nagaraju Nalaparaju Sarasija Madderla Lakshmi Vijaya B. Microwave assisted synthesis of 1H-tetrazole-based flavonoid derivatives and their antimicrobial activity Journal of the Serbian Chemical Society 4-(1H-tetrazol-5-yl) benzaldehyde chalcone aurone microwave irradiation antimicrobial activity. |
| title | Microwave assisted synthesis of 1H-tetrazole-based flavonoid derivatives and their antimicrobial activity |
| title_full | Microwave assisted synthesis of 1H-tetrazole-based flavonoid derivatives and their antimicrobial activity |
| title_fullStr | Microwave assisted synthesis of 1H-tetrazole-based flavonoid derivatives and their antimicrobial activity |
| title_full_unstemmed | Microwave assisted synthesis of 1H-tetrazole-based flavonoid derivatives and their antimicrobial activity |
| title_short | Microwave assisted synthesis of 1H-tetrazole-based flavonoid derivatives and their antimicrobial activity |
| title_sort | microwave assisted synthesis of 1h tetrazole based flavonoid derivatives and their antimicrobial activity |
| topic | 4-(1H-tetrazol-5-yl) benzaldehyde chalcone aurone microwave irradiation antimicrobial activity. |
| url | http://www.doiserbia.nb.rs/img/doi/0352-5139/2018/0352-51391800064A.pdf |
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