Anti-angiogenic drug aggravates the degree of anti-resorptive drug-based medication-related osteonecrosis of the jaw by impairing the proliferation and migration function of gingival fibroblasts

Anti-angiogenic drug aggravates the degree of anti-resorptive drug-based medication-related osteonecrosis of the jaw by impairing the proliferation and migration function of gingival fibroblasts

Abstract Background Long-term use of anti-resorptive or anti-angiogenic drugs in cancer patients with odontogenic infections may lead to medication-related osteonecrosis of the jaw (MRONJ). This study investigated whether anti-angiogenic agents aggravate MRONJ occurrence in anti-resorptive-treated p...

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Bibliographic Details
Main Authors:	Ning Zhao, Qing-xiang Li, Yi-fei Wang, Qiao Qiao, Hong-yuan Huang, Chuan-bin Guo, Yu-xing Guo
Format:	Article
Language:	English
Published:	BMC 2023-05-01
Series:	BMC Oral Health
Subjects:	Anti-angiogenic Anti-resorptive Medication-related osteonecrosis of the jaw Gingival fibroblasts Proliferation and migration
Online Access:	https://doi.org/10.1186/s12903-023-03034-7

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