Lipopolysaccharide downregulates the expression of ZO-1 protein through the Akt pathway

Lipopolysaccharide downregulates the expression of ZO-1 protein through the Akt pathway

Abstract Background Neonatal bacterial meningitis is a common neonatal disease with high morbidity, and can cause serious sequelae when left untreated. Escherichia coli is the common pathogen, and its endotoxin, lipopolysaccharide (LPS) can damage the endothelial cells, increasing the permeability o...

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Bibliographic Details
Main Authors: Peicen Zou, Fan Yang, Yijun Ding, Di Zhang, Ying Liu, Jinjing Zhang, Dan Wu, Yajuan Wang
Format: Article
Language:English
Published: BMC 2022-10-01
Series:BMC Infectious Diseases
Subjects:
LPS
Blood-brain barrier
Tight junction protein
PI3K/Akt signal pathway
Online Access:https://doi.org/10.1186/s12879-022-07752-1

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