Antinociceptive Effect of Some Biuret Derivatives on Formalin Test in Mice
Purpose: The current study was designed to investigate the antinociceptive effects of several biuret derivatives with N, N`-diphenyl, N-phenyl-N`-alkylphenyl, N,N`-bis alkylphenyl, 2-methylquinoline-4-yl, benzo[d]thiazol-2-ylthio and (1-phenyl-1H-tetrazol-5-yl)thio substituents on the formalin-evoke...
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| Format: | Article |
| Language: | English |
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Tabriz University of Medical Sciences
2014-03-01
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| Series: | Advanced Pharmaceutical Bulletin |
| Subjects: | |
| Online Access: | http://journals.tbzmed.ac.ir/APB/Manuscript/APB-4-179.pdf |
| _version_ | 1819042489864028160 |
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| author | Neda Adibpour Ali Poornajjari Mohammad Javad Khodayar Saeed Rezaee |
| author_facet | Neda Adibpour Ali Poornajjari Mohammad Javad Khodayar Saeed Rezaee |
| author_sort | Neda Adibpour |
| collection | DOAJ |
| description | Purpose: The current study was designed to investigate the antinociceptive effects of several biuret derivatives with N, N`-diphenyl, N-phenyl-N`-alkylphenyl, N,N`-bis alkylphenyl, 2-methylquinoline-4-yl, benzo[d]thiazol-2-ylthio and (1-phenyl-1H-tetrazol-5-yl)thio substituents on the formalin-evoked pain in mice.
Methods: Antinociceptive activity of the nine biurets derivatives were assessed at different doses in mice using formalin test and the results were compared with those of indomethacin(20 mg/kg) and vehicle of the compounds. Area under the pain score curve against time (AUEC) up to 60 minutes was used as the measure of pain behavior.
Results: A rather good analgesic effect was seen for most of the tested biuret derivatives. Significant reduction in median AUEC0-5 minutes was observed at the doses of 50 and 25 mg/kg for biurets with either benzyl and 2-methylquinoline-4-yl (C8) or phenylethyl and benzo[d]thiazol-2-ylthio(C9) moieties, respectively(p-value<0.0044). Antinociceptive activities of compound C7 (with bis phenylropyl substituent), C8 and C9 during the late phase of formaldehyde-induced pain were comparable to that of indomethacin.
Conclusion: Unlike indomethacin, the tested biuret compounds are able to induce antinociception in both phases of formalin test and could be considered comparable to indomethacin at the selected doses. |
| first_indexed | 2024-12-21T09:41:43Z |
| format | Article |
| id | doaj.art-b38f933d03884b4192083d4af909499a |
| institution | Directory Open Access Journal |
| issn | 2228-5881 2251-7308 |
| language | English |
| last_indexed | 2024-12-21T09:41:43Z |
| publishDate | 2014-03-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Advanced Pharmaceutical Bulletin |
| spelling | doaj.art-b38f933d03884b4192083d4af909499a2022-12-21T19:08:26ZengTabriz University of Medical SciencesAdvanced Pharmaceutical Bulletin2228-58812251-73082014-03-014217918310.5681/apb.2014.026Antinociceptive Effect of Some Biuret Derivatives on Formalin Test in MiceNeda Adibpour0Ali Poornajjari1Mohammad Javad Khodayar2Saeed Rezaee3Department of Medicinal Chemistry, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Department of Medicinal Chemistry, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Department of Pharmacology and Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Department of Pharmaceutics, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Purpose: The current study was designed to investigate the antinociceptive effects of several biuret derivatives with N, N`-diphenyl, N-phenyl-N`-alkylphenyl, N,N`-bis alkylphenyl, 2-methylquinoline-4-yl, benzo[d]thiazol-2-ylthio and (1-phenyl-1H-tetrazol-5-yl)thio substituents on the formalin-evoked pain in mice. Methods: Antinociceptive activity of the nine biurets derivatives were assessed at different doses in mice using formalin test and the results were compared with those of indomethacin(20 mg/kg) and vehicle of the compounds. Area under the pain score curve against time (AUEC) up to 60 minutes was used as the measure of pain behavior. Results: A rather good analgesic effect was seen for most of the tested biuret derivatives. Significant reduction in median AUEC0-5 minutes was observed at the doses of 50 and 25 mg/kg for biurets with either benzyl and 2-methylquinoline-4-yl (C8) or phenylethyl and benzo[d]thiazol-2-ylthio(C9) moieties, respectively(p-value<0.0044). Antinociceptive activities of compound C7 (with bis phenylropyl substituent), C8 and C9 during the late phase of formaldehyde-induced pain were comparable to that of indomethacin. Conclusion: Unlike indomethacin, the tested biuret compounds are able to induce antinociception in both phases of formalin test and could be considered comparable to indomethacin at the selected doses.http://journals.tbzmed.ac.ir/APB/Manuscript/APB-4-179.pdfBiuret derivativesAntinociceptive effectFormalin testMice |
| spellingShingle | Neda Adibpour Ali Poornajjari Mohammad Javad Khodayar Saeed Rezaee Antinociceptive Effect of Some Biuret Derivatives on Formalin Test in Mice Advanced Pharmaceutical Bulletin Biuret derivatives Antinociceptive effect Formalin test Mice |
| title | Antinociceptive Effect of Some Biuret Derivatives on Formalin Test in Mice |
| title_full | Antinociceptive Effect of Some Biuret Derivatives on Formalin Test in Mice |
| title_fullStr | Antinociceptive Effect of Some Biuret Derivatives on Formalin Test in Mice |
| title_full_unstemmed | Antinociceptive Effect of Some Biuret Derivatives on Formalin Test in Mice |
| title_short | Antinociceptive Effect of Some Biuret Derivatives on Formalin Test in Mice |
| title_sort | antinociceptive effect of some biuret derivatives on formalin test in mice |
| topic | Biuret derivatives Antinociceptive effect Formalin test Mice |
| url | http://journals.tbzmed.ac.ir/APB/Manuscript/APB-4-179.pdf |
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