Global transcriptional downregulation of TREX and nuclear trafficking machinery as pan-senescence phenomena: evidence from human cells and tissues
Aging: Slowing down of nucleocytoplasmic trafficking Proteins that move genetic information out of the nucleus and into the rest of the cell may be important in aging, and serve as markers of early-stage cancer. DNA is stored in the cell’s nucleus, and the messages which it encodes must be exported...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2020-08-01
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| Series: | Experimental and Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s12276-020-00490-x |
| _version_ | 1819124555574149120 |
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| author | Sung Young Kim Eun Jae Yang Sung Bae Lee Young-Sam Lee Kyoung A. Cho Sang Chul Park |
| author_facet | Sung Young Kim Eun Jae Yang Sung Bae Lee Young-Sam Lee Kyoung A. Cho Sang Chul Park |
| author_sort | Sung Young Kim |
| collection | DOAJ |
| description | Aging: Slowing down of nucleocytoplasmic trafficking Proteins that move genetic information out of the nucleus and into the rest of the cell may be important in aging, and serve as markers of early-stage cancer. DNA is stored in the cell’s nucleus, and the messages which it encodes must be exported from the nucleus for gene expression. Aging is thought to be linked to a decrease in this export, but the exact mechanism remains unclear. Sung Young Kim, Konkuk University School of Medicine, Seoul, South Korea, and co-workers investigated key nuclear export proteins in healthy, cancerous, and aging cells. They found that nuclear export is strongly decreased in aging cells and shows distinctive patterns in very-early-stage cancer cells. These results shed further light on the cellular basis of aging, and may provide novel biomarkers for early cancer detection. |
| first_indexed | 2024-12-22T07:26:06Z |
| format | Article |
| id | doaj.art-b38fea8e142543a68bac03bc0f91fb95 |
| institution | Directory Open Access Journal |
| issn | 1226-3613 2092-6413 |
| language | English |
| last_indexed | 2024-12-22T07:26:06Z |
| publishDate | 2020-08-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Experimental and Molecular Medicine |
| spelling | doaj.art-b38fea8e142543a68bac03bc0f91fb952022-12-21T18:34:09ZengNature Publishing GroupExperimental and Molecular Medicine1226-36132092-64132020-08-015281351135910.1038/s12276-020-00490-xGlobal transcriptional downregulation of TREX and nuclear trafficking machinery as pan-senescence phenomena: evidence from human cells and tissuesSung Young Kim0Eun Jae Yang1Sung Bae Lee2Young-Sam Lee3Kyoung A. Cho4Sang Chul Park5Department of Biochemistry, Konkuk University School of MedicineDepartment of New Biology, DGISTDepartment of Brain & Cognitive Sciences, DGISTDepartment of New Biology, DGISTThe Future Life and Society Research Center, Chonnam National UniversityWell Aging Research Center, Division of Biotechnology, DGISTAging: Slowing down of nucleocytoplasmic trafficking Proteins that move genetic information out of the nucleus and into the rest of the cell may be important in aging, and serve as markers of early-stage cancer. DNA is stored in the cell’s nucleus, and the messages which it encodes must be exported from the nucleus for gene expression. Aging is thought to be linked to a decrease in this export, but the exact mechanism remains unclear. Sung Young Kim, Konkuk University School of Medicine, Seoul, South Korea, and co-workers investigated key nuclear export proteins in healthy, cancerous, and aging cells. They found that nuclear export is strongly decreased in aging cells and shows distinctive patterns in very-early-stage cancer cells. These results shed further light on the cellular basis of aging, and may provide novel biomarkers for early cancer detection.https://doi.org/10.1038/s12276-020-00490-x |
| spellingShingle | Sung Young Kim Eun Jae Yang Sung Bae Lee Young-Sam Lee Kyoung A. Cho Sang Chul Park Global transcriptional downregulation of TREX and nuclear trafficking machinery as pan-senescence phenomena: evidence from human cells and tissues Experimental and Molecular Medicine |
| title | Global transcriptional downregulation of TREX and nuclear trafficking machinery as pan-senescence phenomena: evidence from human cells and tissues |
| title_full | Global transcriptional downregulation of TREX and nuclear trafficking machinery as pan-senescence phenomena: evidence from human cells and tissues |
| title_fullStr | Global transcriptional downregulation of TREX and nuclear trafficking machinery as pan-senescence phenomena: evidence from human cells and tissues |
| title_full_unstemmed | Global transcriptional downregulation of TREX and nuclear trafficking machinery as pan-senescence phenomena: evidence from human cells and tissues |
| title_short | Global transcriptional downregulation of TREX and nuclear trafficking machinery as pan-senescence phenomena: evidence from human cells and tissues |
| title_sort | global transcriptional downregulation of trex and nuclear trafficking machinery as pan senescence phenomena evidence from human cells and tissues |
| url | https://doi.org/10.1038/s12276-020-00490-x |
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