Mortality rate in rheumatoid arthritis-related interstitial lung disease: the role of radiographic patterns
Abstract Background To assess mortality rate (MR) and standardized mortality rate (SMR) of rheumatoid arthritis-related interstitial lung disease (RA-ILD) patients and to evaluate the role of radiographic patterns in mortality. Methods A longitudinal multicentric study was conducted in RA-ILD patien...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-06-01
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| Series: | BMC Pulmonary Medicine |
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| Online Access: | https://doi.org/10.1186/s12890-021-01569-5 |
| _version_ | 1818907552751026176 |
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| author | Maria A. Nieto Maria J. Rodriguez-Nieto Olga Sanchez-Pernaute Fredeswinda Romero-Bueno Leticia Leon Cristina Vadillo Dalifer D. Freites-Nuñez Juan A. Jover Jose L. Álvarez-Sala Lydia Abasolo |
| author_facet | Maria A. Nieto Maria J. Rodriguez-Nieto Olga Sanchez-Pernaute Fredeswinda Romero-Bueno Leticia Leon Cristina Vadillo Dalifer D. Freites-Nuñez Juan A. Jover Jose L. Álvarez-Sala Lydia Abasolo |
| author_sort | Maria A. Nieto |
| collection | DOAJ |
| description | Abstract Background To assess mortality rate (MR) and standardized mortality rate (SMR) of rheumatoid arthritis-related interstitial lung disease (RA-ILD) patients and to evaluate the role of radiographic patterns in mortality. Methods A longitudinal multicentric study was conducted in RA-ILD patients from 2005 to 2015 and followed-up until October 2018 in Madrid. Patients were included in the Neumologia-Reumatología y Enfermedades Autoinmunes Registry, from diagnosis of ILD. The main outcome was all-cause mortality. The radiographic pattern at baseline [usual interstitial pneumonia (UIP), nonspecific interstitial pneumonia (NSIP), or others] was the independent variable. Covariables included sociodemographic and clinical data. Survival techniques were used to estimate MR, expressed per 1000 persons-year with their 95% confidence intervals [CI]. Cox multiple regression model was run to examine the influence of radiographic patterns on survival. SMR [CI] was calculated comparing MR obtained with MR expected in the general population of Madrid by indirect age-gender standardization. Results 47 patients were included with a follow-up 242 patients-year. There were 16 (34%) deaths, and most frequent causes were acute ILD exacerbation and pneumonia. MR was 64.3 [39.4–104.9], and 50% of the patients died at 8.3 years from ILD diagnosis. After adjusting for confounders, (UIP compared to NSIP was associated with higher mortality risk. The overall SMR was 2.57 [1.4–4.17]. Women of 60–75 years of age were the group with the highest SMR. Conclusions RA-ILD is associated with an excess of mortality compared to general population. Our results support that UIP increases the risk of mortality in RA-ILD, regardless other factors. |
| first_indexed | 2024-12-19T21:56:56Z |
| format | Article |
| id | doaj.art-b390e0f9a0be48eb80db57d08694500a |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-12-19T21:56:56Z |
| publishDate | 2021-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-b390e0f9a0be48eb80db57d08694500a2022-12-21T20:04:16ZengBMCBMC Pulmonary Medicine1471-24662021-06-012111910.1186/s12890-021-01569-5Mortality rate in rheumatoid arthritis-related interstitial lung disease: the role of radiographic patternsMaria A. Nieto0Maria J. Rodriguez-Nieto1Olga Sanchez-Pernaute2Fredeswinda Romero-Bueno3Leticia Leon4Cristina Vadillo5Dalifer D. Freites-Nuñez6Juan A. Jover7Jose L. Álvarez-Sala8Lydia Abasolo9Pneumology Department Hospital Clínico San CarlosPneumology Department Hospital Fundación Jiménez Díaz UHRheumatology Department Hospital Fundación Jiménez Díaz UHRheumatology Department Hospital Fundación Jiménez Díaz UHInstituto de Investigacion Sanitaria San Carlos (IdISSC) Hospital Clínico San CarlosRheumatology Department Hospital Clínico San CarlosInstituto de Investigacion Sanitaria San Carlos (IdISSC) Hospital Clínico San CarlosUniversidad ComplutensePneumology Department Hospital Clínico San CarlosInstituto de Investigacion Sanitaria San Carlos (IdISSC) Hospital Clínico San CarlosAbstract Background To assess mortality rate (MR) and standardized mortality rate (SMR) of rheumatoid arthritis-related interstitial lung disease (RA-ILD) patients and to evaluate the role of radiographic patterns in mortality. Methods A longitudinal multicentric study was conducted in RA-ILD patients from 2005 to 2015 and followed-up until October 2018 in Madrid. Patients were included in the Neumologia-Reumatología y Enfermedades Autoinmunes Registry, from diagnosis of ILD. The main outcome was all-cause mortality. The radiographic pattern at baseline [usual interstitial pneumonia (UIP), nonspecific interstitial pneumonia (NSIP), or others] was the independent variable. Covariables included sociodemographic and clinical data. Survival techniques were used to estimate MR, expressed per 1000 persons-year with their 95% confidence intervals [CI]. Cox multiple regression model was run to examine the influence of radiographic patterns on survival. SMR [CI] was calculated comparing MR obtained with MR expected in the general population of Madrid by indirect age-gender standardization. Results 47 patients were included with a follow-up 242 patients-year. There were 16 (34%) deaths, and most frequent causes were acute ILD exacerbation and pneumonia. MR was 64.3 [39.4–104.9], and 50% of the patients died at 8.3 years from ILD diagnosis. After adjusting for confounders, (UIP compared to NSIP was associated with higher mortality risk. The overall SMR was 2.57 [1.4–4.17]. Women of 60–75 years of age were the group with the highest SMR. Conclusions RA-ILD is associated with an excess of mortality compared to general population. Our results support that UIP increases the risk of mortality in RA-ILD, regardless other factors.https://doi.org/10.1186/s12890-021-01569-5Rheumatoid arthritisInterstitial lung diseaseMortality |
| spellingShingle | Maria A. Nieto Maria J. Rodriguez-Nieto Olga Sanchez-Pernaute Fredeswinda Romero-Bueno Leticia Leon Cristina Vadillo Dalifer D. Freites-Nuñez Juan A. Jover Jose L. Álvarez-Sala Lydia Abasolo Mortality rate in rheumatoid arthritis-related interstitial lung disease: the role of radiographic patterns BMC Pulmonary Medicine Rheumatoid arthritis Interstitial lung disease Mortality |
| title | Mortality rate in rheumatoid arthritis-related interstitial lung disease: the role of radiographic patterns |
| title_full | Mortality rate in rheumatoid arthritis-related interstitial lung disease: the role of radiographic patterns |
| title_fullStr | Mortality rate in rheumatoid arthritis-related interstitial lung disease: the role of radiographic patterns |
| title_full_unstemmed | Mortality rate in rheumatoid arthritis-related interstitial lung disease: the role of radiographic patterns |
| title_short | Mortality rate in rheumatoid arthritis-related interstitial lung disease: the role of radiographic patterns |
| title_sort | mortality rate in rheumatoid arthritis related interstitial lung disease the role of radiographic patterns |
| topic | Rheumatoid arthritis Interstitial lung disease Mortality |
| url | https://doi.org/10.1186/s12890-021-01569-5 |
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