Changes in the hormone and lipid profile of obese adolescent Saudi females with acne vulgaris
Acne vulgaris is a multifactorial disease affecting a majority of the adolescent population. The objective of this study was to test for a correlation between fasting serum lipid profiles and levels of testosterone, insulin, leptin, and interleukin 1-β (IL-1β) and the incidence of...
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2009-06-01
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| Series: | Brazilian Journal of Medical and Biological Research |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000600005 |
| _version_ | 1818624019586351104 |
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| author | K.O. Abulnaja |
| author_facet | K.O. Abulnaja |
| author_sort | K.O. Abulnaja |
| collection | DOAJ |
| description | Acne vulgaris is a multifactorial disease affecting a majority of the adolescent population. The objective of this study was to test for a correlation between fasting serum lipid profiles and levels of testosterone, insulin, leptin, and interleukin 1-β (IL-1β) and the incidence of severe acne vulgaris in obese adolescent females. Four groups of adolescent females were studied: obese with acne, obese without acne, non-obese with acne, and non-obese without acne. Obese females with acne, compared to obese females without acne and non-obese subjects, had significantly higher serum triglycerides, low-density lipoprotein cholesterol and apolipoprotein-B (apo-B) (mean ± SD: 197 ± 13.7 vs 171 ± 11.5, 128 ± 8.3 vs 116 ± 7.7, 96 ± 13.7 vs 85 ± 10.3 mg/dL, respectively) but significantly lower high-density lipoprotein cholesterol and apo-A1 levels (40 ± 3.3 vs 33 ± 3.5 and 126 ± 12 vs 147 ± 13 mg/dL). Serum testosterone, insulin and leptin levels were significantly higher in obese subjects with or without acne compared to non-obese females with or without acne (3 ± 0.5 vs 2.1 ± 0.47, 15.5 ± 3.3 vs 11.6 ± 3, 0.9 ± 0.2 vs 0.6 ± 0.15 nmol/mL, respectively). Serum IL-1b was significantly elevated in obese and non-obese subjects with acne compared to subjects without acne; in those without acne, these levels were higher in obese than non-obese subjects (2.4 ± 0.2, 1.4 ± 0.1 vs 1.8 ± 0.12 and 1.3 ± 0.11 pg/mL, respectively). Our results indicate that there is a relationship between obesity (BMI >27) and acne. By early recognition, the etiology and treatment protocol of acne may prevent unwanted conditions. |
| first_indexed | 2024-12-16T18:50:18Z |
| format | Article |
| id | doaj.art-b3912aadc14e4c20ac6369d8e42d88d7 |
| institution | Directory Open Access Journal |
| issn | 0100-879X 1414-431X |
| language | English |
| last_indexed | 2024-12-16T18:50:18Z |
| publishDate | 2009-06-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-b3912aadc14e4c20ac6369d8e42d88d72022-12-21T22:20:43ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X2009-06-0142650150510.1590/S0100-879X2009000600005Changes in the hormone and lipid profile of obese adolescent Saudi females with acne vulgarisK.O. AbulnajaAcne vulgaris is a multifactorial disease affecting a majority of the adolescent population. The objective of this study was to test for a correlation between fasting serum lipid profiles and levels of testosterone, insulin, leptin, and interleukin 1-β (IL-1β) and the incidence of severe acne vulgaris in obese adolescent females. Four groups of adolescent females were studied: obese with acne, obese without acne, non-obese with acne, and non-obese without acne. Obese females with acne, compared to obese females without acne and non-obese subjects, had significantly higher serum triglycerides, low-density lipoprotein cholesterol and apolipoprotein-B (apo-B) (mean ± SD: 197 ± 13.7 vs 171 ± 11.5, 128 ± 8.3 vs 116 ± 7.7, 96 ± 13.7 vs 85 ± 10.3 mg/dL, respectively) but significantly lower high-density lipoprotein cholesterol and apo-A1 levels (40 ± 3.3 vs 33 ± 3.5 and 126 ± 12 vs 147 ± 13 mg/dL). Serum testosterone, insulin and leptin levels were significantly higher in obese subjects with or without acne compared to non-obese females with or without acne (3 ± 0.5 vs 2.1 ± 0.47, 15.5 ± 3.3 vs 11.6 ± 3, 0.9 ± 0.2 vs 0.6 ± 0.15 nmol/mL, respectively). Serum IL-1b was significantly elevated in obese and non-obese subjects with acne compared to subjects without acne; in those without acne, these levels were higher in obese than non-obese subjects (2.4 ± 0.2, 1.4 ± 0.1 vs 1.8 ± 0.12 and 1.3 ± 0.11 pg/mL, respectively). Our results indicate that there is a relationship between obesity (BMI >27) and acne. By early recognition, the etiology and treatment protocol of acne may prevent unwanted conditions.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000600005Acne vulgarisObesityTestosteroneAdolescent femalesSerum IL-1β |
| spellingShingle | K.O. Abulnaja Changes in the hormone and lipid profile of obese adolescent Saudi females with acne vulgaris Brazilian Journal of Medical and Biological Research Acne vulgaris Obesity Testosterone Adolescent females Serum IL-1β |
| title | Changes in the hormone and lipid profile of obese adolescent Saudi females with acne vulgaris |
| title_full | Changes in the hormone and lipid profile of obese adolescent Saudi females with acne vulgaris |
| title_fullStr | Changes in the hormone and lipid profile of obese adolescent Saudi females with acne vulgaris |
| title_full_unstemmed | Changes in the hormone and lipid profile of obese adolescent Saudi females with acne vulgaris |
| title_short | Changes in the hormone and lipid profile of obese adolescent Saudi females with acne vulgaris |
| title_sort | changes in the hormone and lipid profile of obese adolescent saudi females with acne vulgaris |
| topic | Acne vulgaris Obesity Testosterone Adolescent females Serum IL-1β |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000600005 |
| work_keys_str_mv | AT koabulnaja changesinthehormoneandlipidprofileofobeseadolescentsaudifemaleswithacnevulgaris |