The AKT inhibitor, MK-2206, attenuates ABCG2-mediated drug resistance in lung and colon cancer cells

The AKT inhibitor, MK-2206, attenuates ABCG2-mediated drug resistance in lung and colon cancer cells

Introduction: The overexpression of ATP-binding cassette (ABC) transporters, ABCB1 and ABCG2, are two of the major mediators of multidrug resistance (MDR) in cancers. Although multiple ABCB1 and ABCG2 inhibitors have been developed and some have undergone evaluation in clinical trials, none have bee...

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Bibliographic Details
Main Authors: Hai-Ling Gao, Qingbin Cui, Jing-Quan Wang, Charles R. Ashby, Yanchun Chen, Zhi-Xin Shen, Zhe-Sheng Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Pharmacology
Subjects:
cancer
MDR
ABCG2
MK-2206
sensitization
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1235285/full

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