Effects of Zingiber officinalis (WILLD.) ROSC. Membranes on minor recurrent aphthous stomatitis: a randomized pragmatic trial
Objective: To evaluate the effects of dried ginger rhizome (DGR; Zingiber officinalis (WILLD.) ROSC.), prepared as a membrane, in minor recurrent aphthous stomatitis (miRAS) treatment and explore its mechanism of action by detecting changes in levels of epidermal growth factor (EGF) and tumor necros...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2018-01-01
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| Series: | Journal of Traditional Chinese Medical Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2095754818300310 |
| _version_ | 1797723995881078784 |
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| author | Qian Du Shenglou Ni Lin Guo Wenjie Song Kun Zhao Ni Liu Xinrong Wang Xun Ma Yanling Fu Quanming Tan |
| author_facet | Qian Du Shenglou Ni Lin Guo Wenjie Song Kun Zhao Ni Liu Xinrong Wang Xun Ma Yanling Fu Quanming Tan |
| author_sort | Qian Du |
| collection | DOAJ |
| description | Objective: To evaluate the effects of dried ginger rhizome (DGR; Zingiber officinalis (WILLD.) ROSC.), prepared as a membrane, in minor recurrent aphthous stomatitis (miRAS) treatment and explore its mechanism of action by detecting changes in levels of epidermal growth factor (EGF) and tumor necrosis factor (TNF)-α in saliva.
Methods: Fifty-nine miRAS patients were enrolled in this study. The number of participants in the dried ginger rhizome membrane (DGRM) group was 30, and 29 were in the placebo membrane (PM) group. Sixty sealed envelopes containing either type of membrane were coded randomly. Investigators and participants were blinded to group assignments. A visual analog scale (VAS) was used for pain, follow-up information for healing time, and enzyme-linked immunosorbent assays to measure the concentrations of EGF and TNF-α.
Results: In terms of VAS, there was a significant difference between pre- and post-DGRM treatment (P < .001), but not so for the PM group (P > .05). A significant difference was observed in the healing time between the two groups (6.08 (2.712) vs. 8.04 (2.142) days). The mean healing time in the DGRM group was shorter than that in the PM group (P < .05). In both groups, the salivary EGF concentration decreased significantly after treatment (P < .05), but the mean level in the DGRM group was significantly lower than that in the PM group (P < .05). The mean TNF-α level in both groups was increased significantly after treatment (P < .05), but patients who used DGRMs had a significantly lower level than that in the PM group (P < .05).
Conclusion: The present study provides evidence that DGRMs are effective treatment for RAS. Dried ginger rhizome has obvious effects on pain relief, shortening of healing time, reducing the EGF level in saliva, and has an inhibitory effect on TNF-α release. |
| first_indexed | 2024-03-12T10:10:53Z |
| format | Article |
| id | doaj.art-b3937fbf07fc4d3981858d24319cefd9 |
| institution | Directory Open Access Journal |
| issn | 2095-7548 |
| language | English |
| last_indexed | 2024-03-12T10:10:53Z |
| publishDate | 2018-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Traditional Chinese Medical Sciences |
| spelling | doaj.art-b3937fbf07fc4d3981858d24319cefd92023-09-02T10:53:44ZengElsevierJournal of Traditional Chinese Medical Sciences2095-75482018-01-0151586310.1016/j.jtcms.2018.02.004Effects of Zingiber officinalis (WILLD.) ROSC. Membranes on minor recurrent aphthous stomatitis: a randomized pragmatic trialQian Du0Shenglou Ni1Lin Guo2Wenjie Song3Kun Zhao4Ni Liu5Xinrong Wang6Xun Ma7Yanling Fu8Quanming Tan9Beijing University of Chinese Medicine, Beijing 100029, ChinaBeijing University of Chinese Medicine, Beijing 100029, ChinaBeijing University of Chinese Medicine, Beijing 100029, ChinaBeijing University of Chinese Medicine, Beijing 100029, ChinaBeijing University of Chinese Medicine, Beijing 100029, ChinaBeijing University of Chinese Medicine, Beijing 100029, ChinaBeijing University of Chinese Medicine, Beijing 100029, ChinaBeijing University of Chinese Medicine, Beijing 100029, ChinaBeijing University of Chinese Medicine, Beijing 100029, ChinaSingapore Thong Chai Medical Institution, Thong Chai Building 169874, SingaporeObjective: To evaluate the effects of dried ginger rhizome (DGR; Zingiber officinalis (WILLD.) ROSC.), prepared as a membrane, in minor recurrent aphthous stomatitis (miRAS) treatment and explore its mechanism of action by detecting changes in levels of epidermal growth factor (EGF) and tumor necrosis factor (TNF)-α in saliva. Methods: Fifty-nine miRAS patients were enrolled in this study. The number of participants in the dried ginger rhizome membrane (DGRM) group was 30, and 29 were in the placebo membrane (PM) group. Sixty sealed envelopes containing either type of membrane were coded randomly. Investigators and participants were blinded to group assignments. A visual analog scale (VAS) was used for pain, follow-up information for healing time, and enzyme-linked immunosorbent assays to measure the concentrations of EGF and TNF-α. Results: In terms of VAS, there was a significant difference between pre- and post-DGRM treatment (P < .001), but not so for the PM group (P > .05). A significant difference was observed in the healing time between the two groups (6.08 (2.712) vs. 8.04 (2.142) days). The mean healing time in the DGRM group was shorter than that in the PM group (P < .05). In both groups, the salivary EGF concentration decreased significantly after treatment (P < .05), but the mean level in the DGRM group was significantly lower than that in the PM group (P < .05). The mean TNF-α level in both groups was increased significantly after treatment (P < .05), but patients who used DGRMs had a significantly lower level than that in the PM group (P < .05). Conclusion: The present study provides evidence that DGRMs are effective treatment for RAS. Dried ginger rhizome has obvious effects on pain relief, shortening of healing time, reducing the EGF level in saliva, and has an inhibitory effect on TNF-α release.http://www.sciencedirect.com/science/article/pii/S2095754818300310Dried ginger rhizome membraneRecurrent aphthous stomatitisEpidermal growth factorTumor necrosis factor-α |
| spellingShingle | Qian Du Shenglou Ni Lin Guo Wenjie Song Kun Zhao Ni Liu Xinrong Wang Xun Ma Yanling Fu Quanming Tan Effects of Zingiber officinalis (WILLD.) ROSC. Membranes on minor recurrent aphthous stomatitis: a randomized pragmatic trial Journal of Traditional Chinese Medical Sciences Dried ginger rhizome membrane Recurrent aphthous stomatitis Epidermal growth factor Tumor necrosis factor-α |
| title | Effects of Zingiber officinalis (WILLD.) ROSC. Membranes on minor recurrent aphthous stomatitis: a randomized pragmatic trial |
| title_full | Effects of Zingiber officinalis (WILLD.) ROSC. Membranes on minor recurrent aphthous stomatitis: a randomized pragmatic trial |
| title_fullStr | Effects of Zingiber officinalis (WILLD.) ROSC. Membranes on minor recurrent aphthous stomatitis: a randomized pragmatic trial |
| title_full_unstemmed | Effects of Zingiber officinalis (WILLD.) ROSC. Membranes on minor recurrent aphthous stomatitis: a randomized pragmatic trial |
| title_short | Effects of Zingiber officinalis (WILLD.) ROSC. Membranes on minor recurrent aphthous stomatitis: a randomized pragmatic trial |
| title_sort | effects of zingiber officinalis willd rosc membranes on minor recurrent aphthous stomatitis a randomized pragmatic trial |
| topic | Dried ginger rhizome membrane Recurrent aphthous stomatitis Epidermal growth factor Tumor necrosis factor-α |
| url | http://www.sciencedirect.com/science/article/pii/S2095754818300310 |
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