A comprehensive overview of exosomes in ovarian cancer: emerging biomarkers and therapeutic strategies
Abstract Exosomes are nanoparticles(40-100 nm) secreted by most cells in the body, which can be isolated from several types of extracellular fluids. It has been shown that exosomes play a key role in intercellular communication and in transportation of genetic information. Emerging evidence shows th...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2017-11-01
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| Series: | Journal of Ovarian Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13048-017-0368-6 |
| _version_ | 1797967945186410496 |
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| author | Lin Cheng Shuying Wu Kun Zhang Yun’an Qing Tianmin Xu |
| author_facet | Lin Cheng Shuying Wu Kun Zhang Yun’an Qing Tianmin Xu |
| author_sort | Lin Cheng |
| collection | DOAJ |
| description | Abstract Exosomes are nanoparticles(40-100 nm) secreted by most cells in the body, which can be isolated from several types of extracellular fluids. It has been shown that exosomes play a key role in intercellular communication and in transportation of genetic information. Emerging evidence shows that exosomes are mediators of metastasis in tumour cells, stromal cells and the extracellular matrix component through the shuttling of cargo, such as proteins, lipids, RNAs, double-stranded DNAs, non-transcribed RNAs, and microRNAs. This phenomenon has been indicated in both tumourigenesis and drug resistance. In this review, we introduce new methods of exosome extraction, focusing on the emerging role of exosomes in ovarian cancer, and discuss their potential clinical applications. |
| first_indexed | 2024-04-11T02:39:16Z |
| format | Article |
| id | doaj.art-b394bdb50df84e7b97df054cb53dfb6f |
| institution | Directory Open Access Journal |
| issn | 1757-2215 |
| language | English |
| last_indexed | 2024-04-11T02:39:16Z |
| publishDate | 2017-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Ovarian Research |
| spelling | doaj.art-b394bdb50df84e7b97df054cb53dfb6f2023-01-02T19:29:58ZengBMCJournal of Ovarian Research1757-22152017-11-011011910.1186/s13048-017-0368-6A comprehensive overview of exosomes in ovarian cancer: emerging biomarkers and therapeutic strategiesLin Cheng0Shuying Wu1Kun Zhang2Yun’an Qing3Tianmin Xu4The Second Hospital of Jilin UniversityThe Second Hospital of Jilin UniversityThe Second Hospital of Jilin UniversityThe Second Hospital of Jilin UniversityThe Second Hospital of Jilin UniversityAbstract Exosomes are nanoparticles(40-100 nm) secreted by most cells in the body, which can be isolated from several types of extracellular fluids. It has been shown that exosomes play a key role in intercellular communication and in transportation of genetic information. Emerging evidence shows that exosomes are mediators of metastasis in tumour cells, stromal cells and the extracellular matrix component through the shuttling of cargo, such as proteins, lipids, RNAs, double-stranded DNAs, non-transcribed RNAs, and microRNAs. This phenomenon has been indicated in both tumourigenesis and drug resistance. In this review, we introduce new methods of exosome extraction, focusing on the emerging role of exosomes in ovarian cancer, and discuss their potential clinical applications.http://link.springer.com/article/10.1186/s13048-017-0368-6ExosomesOvarian cancerProteinRNADNA |
| spellingShingle | Lin Cheng Shuying Wu Kun Zhang Yun’an Qing Tianmin Xu A comprehensive overview of exosomes in ovarian cancer: emerging biomarkers and therapeutic strategies Journal of Ovarian Research Exosomes Ovarian cancer Protein RNA DNA |
| title | A comprehensive overview of exosomes in ovarian cancer: emerging biomarkers and therapeutic strategies |
| title_full | A comprehensive overview of exosomes in ovarian cancer: emerging biomarkers and therapeutic strategies |
| title_fullStr | A comprehensive overview of exosomes in ovarian cancer: emerging biomarkers and therapeutic strategies |
| title_full_unstemmed | A comprehensive overview of exosomes in ovarian cancer: emerging biomarkers and therapeutic strategies |
| title_short | A comprehensive overview of exosomes in ovarian cancer: emerging biomarkers and therapeutic strategies |
| title_sort | comprehensive overview of exosomes in ovarian cancer emerging biomarkers and therapeutic strategies |
| topic | Exosomes Ovarian cancer Protein RNA DNA |
| url | http://link.springer.com/article/10.1186/s13048-017-0368-6 |
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