Harnessing Clinical Trial and Real-World Data Towards an Understanding of Sex Effects on Drug Pharmacokinetics, Pharmacodynamics and Efficacy

Harnessing Clinical Trial and Real-World Data Towards an Understanding of Sex Effects on Drug Pharmacokinetics, Pharmacodynamics and Efficacy

Increasing clinical data on sex-related differences in drug efficacy and toxicity has highlighted the importance of understanding the impact of sex on drug pharmacokinetics and pharmacodynamics. Intrinsic differences between males and females, such as different CYP enzyme activity, drug transporter...

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Bibliographic Details
Main Authors: Joyce Oi Yan Chan, Marie Moullet, Beth Williamson, Rosalinda H. Arends, Venkatesh Pilla Reddy
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Pharmacology
Subjects:
clinical pharmacology
drug metabolism
pk
sex
POPPK
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.874606/full

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