Association of High Serum Adiponectin Level With Adverse Cardiovascular Outcomes and Progression of Coronary Artery Calcification in Patients With Pre-dialysis Chronic Kidney Disease
Background: Serum adiponectin level predicts cardiovascular (CV) outcomes and progression of coronary artery calcification (CAC) in the general population, although the association has not been validated in patients with chronic kidney disease (CKD). In this study, we investigated the association of...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-01-01
|
| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2021.789488/full |
| _version_ | 1830209233880088576 |
|---|---|
| author | Sang Heon Suh Tae Ryom Oh Hong Sang Choi Chang Seong Kim Joongyub Lee Yun Kyu Oh Ji Yong Jung Kyu-Beck Lee Kook-Hwan Oh Seong Kwon Ma Eun Hui Bae Soo Wan Kim |
| author_facet | Sang Heon Suh Tae Ryom Oh Hong Sang Choi Chang Seong Kim Joongyub Lee Yun Kyu Oh Ji Yong Jung Kyu-Beck Lee Kook-Hwan Oh Seong Kwon Ma Eun Hui Bae Soo Wan Kim |
| author_sort | Sang Heon Suh |
| collection | DOAJ |
| description | Background: Serum adiponectin level predicts cardiovascular (CV) outcomes and progression of coronary artery calcification (CAC) in the general population, although the association has not been validated in patients with chronic kidney disease (CKD). In this study, we investigated the association of high serum adiponectin level with the risk of adverse CV outcomes and progression of CAC in patients with pre-dialysis CKD.Methods: A total of 1,127 patients with pre-dialysis CKD from a nationwide prospective cohort of patients with pre-dialysis CKD in Korea were divided into the tertile by serum adiponectin level at the baseline. CV outcome of interest was fatal and non-fatal CV events and all-cause mortality. Progression of CAC was defined as coronary artery calcium score (CACS) change more than 200 during a 4-year follow-up.Results: Cox regression analysis revealed that high serum adiponectin is associated with increased risk of fatal and non-fatal CV events (adjusted hazard ratio 2.799, 95% CI 1.348–5.811). In contrast, high serum adiponectin level was not significantly associated with all-cause mortality (adjusted hazard ratio 0.655, 95% CI 0.203–2.113). Binary logistic regression analysis revealed that high serum adiponectin level is also associated with increased risk of progression of CAC (adjusted odds ratio [OR] 2.078, 95% CI 1.014–4.260). Subgroup analyses demonstrated that the association of high serum adiponectin with increased risk of fatal and non-fatal CV events is not modified by age, gender, history of diabetes, estimated glomerular filtration rate (eGFR), or spot urine albumin-to-creatinine ratio (ACR).Conclusions: High serum adiponectin level is associated with adverse CV outcomes and progression of CAC in patients with pre-dialysis CKD. |
| first_indexed | 2024-12-18T05:03:36Z |
| format | Article |
| id | doaj.art-b3957f28e8e542d9b1035d15b513e4d5 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-18T05:03:36Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-b3957f28e8e542d9b1035d15b513e4d52022-12-21T21:20:04ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-01-01810.3389/fcvm.2021.789488789488Association of High Serum Adiponectin Level With Adverse Cardiovascular Outcomes and Progression of Coronary Artery Calcification in Patients With Pre-dialysis Chronic Kidney DiseaseSang Heon Suh0Tae Ryom Oh1Hong Sang Choi2Chang Seong Kim3Joongyub Lee4Yun Kyu Oh5Ji Yong Jung6Kyu-Beck Lee7Kook-Hwan Oh8Seong Kwon Ma9Eun Hui Bae10Soo Wan Kim11Department of Internal Medicine, Chonnam National University Medical School and Chonnam National University Hospital, Gwangju, South KoreaDepartment of Internal Medicine, Chonnam National University Medical School and Chonnam National University Hospital, Gwangju, South KoreaDepartment of Internal Medicine, Chonnam National University Medical School and Chonnam National University Hospital, Gwangju, South KoreaDepartment of Internal Medicine, Chonnam National University Medical School and Chonnam National University Hospital, Gwangju, South KoreaDepartment of Prevention and Management, School of Medicine, Inha University, Incheon, South KoreaDepartment of Internal Medicine, Seoul National University, Seoul, South KoreaDivision of Nephrology, Department of Internal Medicine, Gachon University of Gil Medical Center, Incheon, South KoreaDepartment of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South KoreaDepartment of Internal Medicine, Seoul National University, Seoul, South KoreaDepartment of Internal Medicine, Chonnam National University Medical School and Chonnam National University Hospital, Gwangju, South KoreaDepartment of Internal Medicine, Chonnam National University Medical School and Chonnam National University Hospital, Gwangju, South KoreaDepartment of Internal Medicine, Chonnam National University Medical School and Chonnam National University Hospital, Gwangju, South KoreaBackground: Serum adiponectin level predicts cardiovascular (CV) outcomes and progression of coronary artery calcification (CAC) in the general population, although the association has not been validated in patients with chronic kidney disease (CKD). In this study, we investigated the association of high serum adiponectin level with the risk of adverse CV outcomes and progression of CAC in patients with pre-dialysis CKD.Methods: A total of 1,127 patients with pre-dialysis CKD from a nationwide prospective cohort of patients with pre-dialysis CKD in Korea were divided into the tertile by serum adiponectin level at the baseline. CV outcome of interest was fatal and non-fatal CV events and all-cause mortality. Progression of CAC was defined as coronary artery calcium score (CACS) change more than 200 during a 4-year follow-up.Results: Cox regression analysis revealed that high serum adiponectin is associated with increased risk of fatal and non-fatal CV events (adjusted hazard ratio 2.799, 95% CI 1.348–5.811). In contrast, high serum adiponectin level was not significantly associated with all-cause mortality (adjusted hazard ratio 0.655, 95% CI 0.203–2.113). Binary logistic regression analysis revealed that high serum adiponectin level is also associated with increased risk of progression of CAC (adjusted odds ratio [OR] 2.078, 95% CI 1.014–4.260). Subgroup analyses demonstrated that the association of high serum adiponectin with increased risk of fatal and non-fatal CV events is not modified by age, gender, history of diabetes, estimated glomerular filtration rate (eGFR), or spot urine albumin-to-creatinine ratio (ACR).Conclusions: High serum adiponectin level is associated with adverse CV outcomes and progression of CAC in patients with pre-dialysis CKD.https://www.frontiersin.org/articles/10.3389/fcvm.2021.789488/fulladiponectincardiovascular diseasecardiovascular eventchronic kidney diseasecoronary artery calcification |
| spellingShingle | Sang Heon Suh Tae Ryom Oh Hong Sang Choi Chang Seong Kim Joongyub Lee Yun Kyu Oh Ji Yong Jung Kyu-Beck Lee Kook-Hwan Oh Seong Kwon Ma Eun Hui Bae Soo Wan Kim Association of High Serum Adiponectin Level With Adverse Cardiovascular Outcomes and Progression of Coronary Artery Calcification in Patients With Pre-dialysis Chronic Kidney Disease Frontiers in Cardiovascular Medicine adiponectin cardiovascular disease cardiovascular event chronic kidney disease coronary artery calcification |
| title | Association of High Serum Adiponectin Level With Adverse Cardiovascular Outcomes and Progression of Coronary Artery Calcification in Patients With Pre-dialysis Chronic Kidney Disease |
| title_full | Association of High Serum Adiponectin Level With Adverse Cardiovascular Outcomes and Progression of Coronary Artery Calcification in Patients With Pre-dialysis Chronic Kidney Disease |
| title_fullStr | Association of High Serum Adiponectin Level With Adverse Cardiovascular Outcomes and Progression of Coronary Artery Calcification in Patients With Pre-dialysis Chronic Kidney Disease |
| title_full_unstemmed | Association of High Serum Adiponectin Level With Adverse Cardiovascular Outcomes and Progression of Coronary Artery Calcification in Patients With Pre-dialysis Chronic Kidney Disease |
| title_short | Association of High Serum Adiponectin Level With Adverse Cardiovascular Outcomes and Progression of Coronary Artery Calcification in Patients With Pre-dialysis Chronic Kidney Disease |
| title_sort | association of high serum adiponectin level with adverse cardiovascular outcomes and progression of coronary artery calcification in patients with pre dialysis chronic kidney disease |
| topic | adiponectin cardiovascular disease cardiovascular event chronic kidney disease coronary artery calcification |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2021.789488/full |
| work_keys_str_mv | AT sangheonsuh associationofhighserumadiponectinlevelwithadversecardiovascularoutcomesandprogressionofcoronaryarterycalcificationinpatientswithpredialysischronickidneydisease AT taeryomoh associationofhighserumadiponectinlevelwithadversecardiovascularoutcomesandprogressionofcoronaryarterycalcificationinpatientswithpredialysischronickidneydisease AT hongsangchoi associationofhighserumadiponectinlevelwithadversecardiovascularoutcomesandprogressionofcoronaryarterycalcificationinpatientswithpredialysischronickidneydisease AT changseongkim associationofhighserumadiponectinlevelwithadversecardiovascularoutcomesandprogressionofcoronaryarterycalcificationinpatientswithpredialysischronickidneydisease AT joongyublee associationofhighserumadiponectinlevelwithadversecardiovascularoutcomesandprogressionofcoronaryarterycalcificationinpatientswithpredialysischronickidneydisease AT yunkyuoh associationofhighserumadiponectinlevelwithadversecardiovascularoutcomesandprogressionofcoronaryarterycalcificationinpatientswithpredialysischronickidneydisease AT jiyongjung associationofhighserumadiponectinlevelwithadversecardiovascularoutcomesandprogressionofcoronaryarterycalcificationinpatientswithpredialysischronickidneydisease AT kyubecklee associationofhighserumadiponectinlevelwithadversecardiovascularoutcomesandprogressionofcoronaryarterycalcificationinpatientswithpredialysischronickidneydisease AT kookhwanoh associationofhighserumadiponectinlevelwithadversecardiovascularoutcomesandprogressionofcoronaryarterycalcificationinpatientswithpredialysischronickidneydisease AT seongkwonma associationofhighserumadiponectinlevelwithadversecardiovascularoutcomesandprogressionofcoronaryarterycalcificationinpatientswithpredialysischronickidneydisease AT eunhuibae associationofhighserumadiponectinlevelwithadversecardiovascularoutcomesandprogressionofcoronaryarterycalcificationinpatientswithpredialysischronickidneydisease AT soowankim associationofhighserumadiponectinlevelwithadversecardiovascularoutcomesandprogressionofcoronaryarterycalcificationinpatientswithpredialysischronickidneydisease |