Acute Inflammation in Tissue Healing
There are well-established links between acute inflammation and successful tissue repair across evolution. Innate immune reactions contribute significantly to pathogen clearance and activation of subsequent reparative events. A network of molecular and cellular regulators supports antimicrobial and...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-12-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/1/641 |
| _version_ | 1797625639898972160 |
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| author | Amro M. Soliman Daniel R. Barreda |
| author_facet | Amro M. Soliman Daniel R. Barreda |
| author_sort | Amro M. Soliman |
| collection | DOAJ |
| description | There are well-established links between acute inflammation and successful tissue repair across evolution. Innate immune reactions contribute significantly to pathogen clearance and activation of subsequent reparative events. A network of molecular and cellular regulators supports antimicrobial and tissue repair functions throughout the healing process. A delicate balance must be achieved between protection and the potential for collateral tissue damage associated with overt inflammation. In this review, we summarize the contributions of key cellular and molecular components to the acute inflammatory process and the effective and timely transition toward activation of tissue repair mechanisms. We further discuss how the disruption of inflammatory responses ultimately results in chronic non-healing injuries. |
| first_indexed | 2024-03-11T09:59:09Z |
| format | Article |
| id | doaj.art-b396fffb901d4cefa10c4081ead160e1 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T09:59:09Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-b396fffb901d4cefa10c4081ead160e12023-11-16T15:36:19ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-12-0124164110.3390/ijms24010641Acute Inflammation in Tissue HealingAmro M. Soliman0Daniel R. Barreda1Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2R3, CanadaDepartment of Biological Sciences, University of Alberta, Edmonton, AB T6G 2R3, CanadaThere are well-established links between acute inflammation and successful tissue repair across evolution. Innate immune reactions contribute significantly to pathogen clearance and activation of subsequent reparative events. A network of molecular and cellular regulators supports antimicrobial and tissue repair functions throughout the healing process. A delicate balance must be achieved between protection and the potential for collateral tissue damage associated with overt inflammation. In this review, we summarize the contributions of key cellular and molecular components to the acute inflammatory process and the effective and timely transition toward activation of tissue repair mechanisms. We further discuss how the disruption of inflammatory responses ultimately results in chronic non-healing injuries.https://www.mdpi.com/1422-0067/24/1/641inflammationtissue repairneutrophilsmacrophageschronic injuriesinflammatory mediators |
| spellingShingle | Amro M. Soliman Daniel R. Barreda Acute Inflammation in Tissue Healing International Journal of Molecular Sciences inflammation tissue repair neutrophils macrophages chronic injuries inflammatory mediators |
| title | Acute Inflammation in Tissue Healing |
| title_full | Acute Inflammation in Tissue Healing |
| title_fullStr | Acute Inflammation in Tissue Healing |
| title_full_unstemmed | Acute Inflammation in Tissue Healing |
| title_short | Acute Inflammation in Tissue Healing |
| title_sort | acute inflammation in tissue healing |
| topic | inflammation tissue repair neutrophils macrophages chronic injuries inflammatory mediators |
| url | https://www.mdpi.com/1422-0067/24/1/641 |
| work_keys_str_mv | AT amromsoliman acuteinflammationintissuehealing AT danielrbarreda acuteinflammationintissuehealing |