Hyaluronic acid versus dexamethasone for the treatment of recurrent aphthous stomatitis in children: efficacy and safety analysis
The objective of this study was to compare the safety and efficacy of 0.2% hyaluronic acid (HA) topical gel and dexamethasone topical ointment in the treatment of recurrent aphthous ulcers (RAU) in children. This retrospective observational study included 104 patients who had more than two episodes...
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2020-06-01
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| Series: | Brazilian Journal of Medical and Biological Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020000800609&tlng=en |
| _version_ | 1798020120949293056 |
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| author | Zheng Yang Miaojuan Li Lin Xiao Zhiming Yi Min Zhao Shengjie Ma |
| author_facet | Zheng Yang Miaojuan Li Lin Xiao Zhiming Yi Min Zhao Shengjie Ma |
| author_sort | Zheng Yang |
| collection | DOAJ |
| description | The objective of this study was to compare the safety and efficacy of 0.2% hyaluronic acid (HA) topical gel and dexamethasone topical ointment in the treatment of recurrent aphthous ulcers (RAU) in children. This retrospective observational study included 104 patients who had more than two episodes of oral aphthous ulcers per year and were treated with HA (n=52) or dexamethasone (n=52) from August 15, 2014 to September 3, 2018. Therapy efficacy was evaluated based on the ulcer size and pain score before versus 7 days after either therapy. The paired t-test, chi-squared test, and independent t-test were utilized for statistical analyses. There was no significant difference in ulcer size or pain score between the HA and dexamethasone groups, on day 1 or day 7. Both treatments were tolerated well and no side effects were reported. No significant differences in body temperature, respiration rate, pulse, or systolic/diastolic blood pressure were observed between the start (day 1) and end of treatment (day 7), for either treatment. HA and dexamethasone showed similar efficacy in reducing ulcer size and pain scores, and were tolerated equally well in children with RAU. Future high-quality studies with larger numbers of patients are needed to confirm our findings. |
| first_indexed | 2024-04-11T16:52:31Z |
| format | Article |
| id | doaj.art-b398a9c2a1c644b6a20566168f85780f |
| institution | Directory Open Access Journal |
| issn | 1414-431X |
| language | English |
| last_indexed | 2024-04-11T16:52:31Z |
| publishDate | 2020-06-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-b398a9c2a1c644b6a20566168f85780f2022-12-22T04:13:25ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research1414-431X2020-06-0153810.1590/1414-431x20209886Hyaluronic acid versus dexamethasone for the treatment of recurrent aphthous stomatitis in children: efficacy and safety analysisZheng Yanghttps://orcid.org/0000-0003-1175-5663Miaojuan Lihttps://orcid.org/0000-0002-2068-2905Lin Xiaohttps://orcid.org/0000-0002-0507-3191Zhiming Yihttps://orcid.org/0000-0002-0152-6405Min Zhaohttps://orcid.org/0000-0001-9989-9092Shengjie Mahttps://orcid.org/0000-0002-1313-0889The objective of this study was to compare the safety and efficacy of 0.2% hyaluronic acid (HA) topical gel and dexamethasone topical ointment in the treatment of recurrent aphthous ulcers (RAU) in children. This retrospective observational study included 104 patients who had more than two episodes of oral aphthous ulcers per year and were treated with HA (n=52) or dexamethasone (n=52) from August 15, 2014 to September 3, 2018. Therapy efficacy was evaluated based on the ulcer size and pain score before versus 7 days after either therapy. The paired t-test, chi-squared test, and independent t-test were utilized for statistical analyses. There was no significant difference in ulcer size or pain score between the HA and dexamethasone groups, on day 1 or day 7. Both treatments were tolerated well and no side effects were reported. No significant differences in body temperature, respiration rate, pulse, or systolic/diastolic blood pressure were observed between the start (day 1) and end of treatment (day 7), for either treatment. HA and dexamethasone showed similar efficacy in reducing ulcer size and pain scores, and were tolerated equally well in children with RAU. Future high-quality studies with larger numbers of patients are needed to confirm our findings.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020000800609&tlng=enDexamethasoneHyaluronic AcidOral ulcerAphthous stomatitisAphthous ulcer |
| spellingShingle | Zheng Yang Miaojuan Li Lin Xiao Zhiming Yi Min Zhao Shengjie Ma Hyaluronic acid versus dexamethasone for the treatment of recurrent aphthous stomatitis in children: efficacy and safety analysis Brazilian Journal of Medical and Biological Research Dexamethasone Hyaluronic Acid Oral ulcer Aphthous stomatitis Aphthous ulcer |
| title | Hyaluronic acid versus dexamethasone for the treatment of recurrent aphthous stomatitis in children: efficacy and safety analysis |
| title_full | Hyaluronic acid versus dexamethasone for the treatment of recurrent aphthous stomatitis in children: efficacy and safety analysis |
| title_fullStr | Hyaluronic acid versus dexamethasone for the treatment of recurrent aphthous stomatitis in children: efficacy and safety analysis |
| title_full_unstemmed | Hyaluronic acid versus dexamethasone for the treatment of recurrent aphthous stomatitis in children: efficacy and safety analysis |
| title_short | Hyaluronic acid versus dexamethasone for the treatment of recurrent aphthous stomatitis in children: efficacy and safety analysis |
| title_sort | hyaluronic acid versus dexamethasone for the treatment of recurrent aphthous stomatitis in children efficacy and safety analysis |
| topic | Dexamethasone Hyaluronic Acid Oral ulcer Aphthous stomatitis Aphthous ulcer |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020000800609&tlng=en |
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