Global ubiquitinome profiling identifies NEDD4 as a regulator of Profilin 1 and actin remodelling in neural crest cells
Here the authors combine multi-omics approaches to uncover a role for ubiquitination and the ubiquitin ligase NEDD4 in targeting the actin binding protein Profilin 1 to regulate actin polymerisation in neural crest cells.
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-29660-3 |
| _version_ | 1828402502749388800 |
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| author | Iman Lohraseb Peter McCarthy Genevieve Secker Ceilidh Marchant Jianmin Wu Naveid Ali Sharad Kumar Roger J. Daly Natasha L. Harvey Hiroshi Kawabe Oded Kleifeld Sophie Wiszniak Quenten Schwarz |
| author_facet | Iman Lohraseb Peter McCarthy Genevieve Secker Ceilidh Marchant Jianmin Wu Naveid Ali Sharad Kumar Roger J. Daly Natasha L. Harvey Hiroshi Kawabe Oded Kleifeld Sophie Wiszniak Quenten Schwarz |
| author_sort | Iman Lohraseb |
| collection | DOAJ |
| description | Here the authors combine multi-omics approaches to uncover a role for ubiquitination and the ubiquitin ligase NEDD4 in targeting the actin binding protein Profilin 1 to regulate actin polymerisation in neural crest cells. |
| first_indexed | 2024-12-10T10:01:12Z |
| format | Article |
| id | doaj.art-b39a1c0a20ae4ebda1ec3a9f3cfebfb7 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-10T10:01:12Z |
| publishDate | 2022-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-b39a1c0a20ae4ebda1ec3a9f3cfebfb72022-12-22T01:53:21ZengNature PortfolioNature Communications2041-17232022-04-0113111810.1038/s41467-022-29660-3Global ubiquitinome profiling identifies NEDD4 as a regulator of Profilin 1 and actin remodelling in neural crest cellsIman Lohraseb0Peter McCarthy1Genevieve Secker2Ceilidh Marchant3Jianmin Wu4Naveid Ali5Sharad Kumar6Roger J. Daly7Natasha L. Harvey8Hiroshi Kawabe9Oded Kleifeld10Sophie Wiszniak11Quenten Schwarz12Centre for Cancer Biology, University of South Australia and SA PathologyCentre for Cancer Biology, University of South Australia and SA PathologyCentre for Cancer Biology, University of South Australia and SA PathologyCentre for Cancer Biology, University of South Australia and SA PathologyKinghorn Cancer Centre & Cancer Division, Garvan Institute of Medical ResearchBone Therapeutics Group, Bone Biology Division, Garvan Institute of Medical ResearchCentre for Cancer Biology, University of South Australia and SA PathologyDepartment of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash UniversityCentre for Cancer Biology, University of South Australia and SA PathologyDepartment of Molecular Neurobiology, Max Planck Institute for Experimental MedicineFaculty of Biology, Technion-Israel Institute of TechnologyCentre for Cancer Biology, University of South Australia and SA PathologyCentre for Cancer Biology, University of South Australia and SA PathologyHere the authors combine multi-omics approaches to uncover a role for ubiquitination and the ubiquitin ligase NEDD4 in targeting the actin binding protein Profilin 1 to regulate actin polymerisation in neural crest cells.https://doi.org/10.1038/s41467-022-29660-3 |
| spellingShingle | Iman Lohraseb Peter McCarthy Genevieve Secker Ceilidh Marchant Jianmin Wu Naveid Ali Sharad Kumar Roger J. Daly Natasha L. Harvey Hiroshi Kawabe Oded Kleifeld Sophie Wiszniak Quenten Schwarz Global ubiquitinome profiling identifies NEDD4 as a regulator of Profilin 1 and actin remodelling in neural crest cells Nature Communications |
| title | Global ubiquitinome profiling identifies NEDD4 as a regulator of Profilin 1 and actin remodelling in neural crest cells |
| title_full | Global ubiquitinome profiling identifies NEDD4 as a regulator of Profilin 1 and actin remodelling in neural crest cells |
| title_fullStr | Global ubiquitinome profiling identifies NEDD4 as a regulator of Profilin 1 and actin remodelling in neural crest cells |
| title_full_unstemmed | Global ubiquitinome profiling identifies NEDD4 as a regulator of Profilin 1 and actin remodelling in neural crest cells |
| title_short | Global ubiquitinome profiling identifies NEDD4 as a regulator of Profilin 1 and actin remodelling in neural crest cells |
| title_sort | global ubiquitinome profiling identifies nedd4 as a regulator of profilin 1 and actin remodelling in neural crest cells |
| url | https://doi.org/10.1038/s41467-022-29660-3 |
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