Glycoside Mimics from Glycosylamines: Recent Progress
Glycosylamines are valuable sugar derivatives that have attracted much attention as synthetic intermediates en route to iminosugar-C-glycosyl compounds. Iminosugars are among the most important glycomimetics reported to date due to their powerful activities as inhibitors of a wide variety of glycosi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-07-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/23/7/1612 |
| _version_ | 1811253199319859200 |
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| author | Cyril Nicolas Olivier R. Martin |
| author_facet | Cyril Nicolas Olivier R. Martin |
| author_sort | Cyril Nicolas |
| collection | DOAJ |
| description | Glycosylamines are valuable sugar derivatives that have attracted much attention as synthetic intermediates en route to iminosugar-C-glycosyl compounds. Iminosugars are among the most important glycomimetics reported to date due to their powerful activities as inhibitors of a wide variety of glycosidases and glycosyltransferases, as well as for their use as pharmacological chaperones. As they provide ready access to these important glycoside mimics, we have reviewed the most significant glycosylamine-based methodologies developed to date, with a special emphasis on the literature reported after 2006. The groups of substrates covered include N-alkyl- and N-benzyl-glycosylamines, N-glycosylhydroxylamines, N-(alkoxycarbonyl)-, and N-tert-butanesulfinyl-glycosylamines. |
| first_indexed | 2024-04-12T16:47:19Z |
| format | Article |
| id | doaj.art-b39ac51155864ea9a48089e777755b8a |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-12T16:47:19Z |
| publishDate | 2018-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-b39ac51155864ea9a48089e777755b8a2022-12-22T03:24:32ZengMDPI AGMolecules1420-30492018-07-01237161210.3390/molecules23071612molecules23071612Glycoside Mimics from Glycosylamines: Recent ProgressCyril Nicolas0Olivier R. Martin1Institute of Organic and Analytical Chemistry, UMR 7311, University of Orleans and CNRS, Rue de Chartres, BP 6759, 45067 Orleans CEDEX 2, FranceInstitute of Organic and Analytical Chemistry, UMR 7311, University of Orleans and CNRS, Rue de Chartres, BP 6759, 45067 Orleans CEDEX 2, FranceGlycosylamines are valuable sugar derivatives that have attracted much attention as synthetic intermediates en route to iminosugar-C-glycosyl compounds. Iminosugars are among the most important glycomimetics reported to date due to their powerful activities as inhibitors of a wide variety of glycosidases and glycosyltransferases, as well as for their use as pharmacological chaperones. As they provide ready access to these important glycoside mimics, we have reviewed the most significant glycosylamine-based methodologies developed to date, with a special emphasis on the literature reported after 2006. The groups of substrates covered include N-alkyl- and N-benzyl-glycosylamines, N-glycosylhydroxylamines, N-(alkoxycarbonyl)-, and N-tert-butanesulfinyl-glycosylamines.http://www.mdpi.com/1420-3049/23/7/1612addition reactionsglycosylaminesiminosugar-C-glycosidesglycomimetics |
| spellingShingle | Cyril Nicolas Olivier R. Martin Glycoside Mimics from Glycosylamines: Recent Progress Molecules addition reactions glycosylamines iminosugar-C-glycosides glycomimetics |
| title | Glycoside Mimics from Glycosylamines: Recent Progress |
| title_full | Glycoside Mimics from Glycosylamines: Recent Progress |
| title_fullStr | Glycoside Mimics from Glycosylamines: Recent Progress |
| title_full_unstemmed | Glycoside Mimics from Glycosylamines: Recent Progress |
| title_short | Glycoside Mimics from Glycosylamines: Recent Progress |
| title_sort | glycoside mimics from glycosylamines recent progress |
| topic | addition reactions glycosylamines iminosugar-C-glycosides glycomimetics |
| url | http://www.mdpi.com/1420-3049/23/7/1612 |
| work_keys_str_mv | AT cyrilnicolas glycosidemimicsfromglycosylaminesrecentprogress AT olivierrmartin glycosidemimicsfromglycosylaminesrecentprogress |